Triacylglycerol hydrolase (TGH), also known as bile salt-stimulated lipase (BSSL) or carboxylesterase 1 (CES1), is an enzyme involved in lipid metabolism, responsible for hydrolyzing triacylglycerols, cholesterol esters, and other lipids. TGH is primarily expressed in the liver and small intestine, and is localized on the cell surface and within cells in the small intestine, where it participates in fat digestion and absorption. TGH plays a key role in regulating blood lipid levels, lipid storage, and energy metabolism. The specific expression and mutations of the gene are associated with various diseases, including obesity, diabetes, cardiovascular diseases, and liver diseases.