Tumor necrosis factor receptors (TNFRs) are a class of cell membrane receptors that bind to tumor necrosis factor (TNF) to regulate inflammation, immune response, and cell death. The TNFR family mainly includes TNFR1 and TNFR2, where TNFR1 typically mediates pro-inflammatory and cell death signals, while TNFR2 is primarily involved in immune regulation and cell survival.