TNK, standing for Tyrosine Kinase Non-Receptor, encompasses a category of non-receptor tyrosine kinases widely involved in various biological processes such as cell proliferation, differentiation, migration, and survival. These kinases are localized in both the cytoplasm and nucleus, mediating signal transduction through the phosphorylation of substrates. TNK family members exhibit specificity in their expression across different tissues and cell types, and their abnormal expression or mutations are closely associated with the development of various diseases, including multiple cancers. Hence, TNK kinases serve as significant biomarkers and potential therapeutic targets.