Vanin is a group of transmembrane proteins with pantetheinase activity, involved in the cleavage of pantothenic acid (vitamin B5). The Vanin family is expressed in various cells and tissues, particularly prominent in kidney and intestinal epithelial cells. They play crucial roles in regulating cellular stress responses, inflammatory reactions, and cell migration. The activity of Vanin is influenced by intracellular and extracellular environments, such as oxidative stress, which can increase its expression. Changes and mutations in specific gene expressions may lead to metabolic abnormalities and increase susceptibility to certain diseases, such as inflammatory bowel disease and cardiovascular diseases.