Home Chemistry Organic Building Blocks Bromides 1-Bromo-3-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—NO2).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
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1-Bromo-4-fluoro-2-methyl-3-nitrobenzene
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