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[ CAS No. 886762-68-1 ]

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Chemical Structure| 886762-68-1
Chemical Structure| 886762-68-1
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Product Details of [ 886762-68-1 ]

CAS No. :886762-68-1 MDL No. :MFCD07368787
Formula : C7H5F2IO Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :270.02 g/mol Pubchem ID :2783151
Synonyms :

Safety of [ 886762-68-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362-P403-P501 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 886762-68-1 ]

  • Downstream synthetic route of [ 886762-68-1 ]

[ 886762-68-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 886762-68-1 ]
  • [ 1226799-76-3 ]
  • [ 1226799-77-4 ]
YieldReaction ConditionsOperation in experiment
19% Example 12i 5-(3-Bromo-4-fluorophenyl)-5-(3,5-difluoro-4-methoxyphenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine tert-Butyllithium (0.995 mL, 1.59 mmol) was added dropwise to THF (4 mL) at -100 C. under an argon atmosphere. A solution of <strong>[886762-68-1]1,3-difluoro-5-iodo-2-methoxybenzene</strong> (215 mg, 0.80 mmol) in THF (1 mL) was added dropwise followed by the addition of N-((3-bromo-4-fluorophenyl)(2-cyanopyridin-3-yl)methylene)-2-methylpropane-2-sulfinamide (250 mg, 0.61 mmol) in THF (2 mL). The resulting reaction mixture was left on the thawing cooling bath for 30 min then the cooling bath was removed and the mixture was stirred at r.t. for 1 h. Hydrogen chloride in methanol (3 mL, 3.7 mmol) was added and the resulting mixture was stirred at r.t. for 1 h. The mixture was concentrated and purified on a silica gel column eluted with 0-10% NH3 (0.1 M in MeOH) in DCM. This gave 52 mg (19% yield) of the title product: MS (ES) m/z 448, 450 [M+1]+.
  • 2
  • [ 950858-06-7 ]
  • [ 74-88-4 ]
  • [ 886762-68-1 ]
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