Home Chemistry Organic Building Blocks Trifluoromethyls 1-Fluoro-4-(Trifluoromethyl)Benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CF3).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
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1-Chloro-2-fluoro-3-methoxy-5-(trifluoromethyl)benzene
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4-Bromo-2-fluoro-5-(trifluoromethyl)phenylboronic acid
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(3-Chloro-2-fluoro-5-(trifluoromethyl)phenyl)boronic acid
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1,5-Difluoro-2-nitro-4-(trifluoromethyl)benzene
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1-Bromo-2-fluoro-3-nitro-5-(trifluoromethyl)benzene
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2,6-Difluoro-3-(trifluoromethyl)benzonitrile
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2,6-Difluoro-3-(trifluoromethyl)benzoic acid
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2-(2-Fluoro-5-(trifluoromethyl)phenyl)acetic acid
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1,3-Dichloro-2-fluoro-5-(trifluoromethyl)benzene
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4-Bromo-2-fluoro-5-(trifluoromethyl)aniline
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2-Fluoro-5-(trifluoromethyl)benzoyl chloride
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2-Fluoro-5-(trifluoromethyl)benzene-1-sulfonyl chloride
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1,2,3,4,5-Pentafluoro-6-(trifluoromethyl)benzene
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2-Fluoro-5-(trifluoromethyl)phenylisocyanate
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2-Fluoro-5-(trifluoromethyl)benzyl Bromide
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