Home Chemistry Organic Building Blocks Trifluoromethyls 1-Fluoro-4-(Trifluoromethyl)Benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CF3).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
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Methyl 2-fluoro-5-(trifluoromethyl)benzoate
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2-Fluoro-5-(trifluoromethyl)phenylboronic acid
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1-Bromo-2-fluoro-4-nitro-5-(trifluoromethyl)benzene
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