Home Chemistry Organic Building Blocks Iodides 1-Fluoro-4-Iodobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —I,—F).
Metalation Reactions: Iodobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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1-Chloro-2-fluoro-5-iodo-3-(trifluoromethyl)benzene
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2-Chloro-1-fluoro-4-iodo-3-methylbenzene
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