450-90-8|4-Fluoro-1-iodo-2-methoxybenzene| Ambeed

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Quality Control of [ 450-90-8 ] Purity: 97% SDS Specification

COA

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NMR

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Product Details of [ 450-90-8 ]

CAS No. :	450-90-8
Formula :	C₇H₆FIO
M.W :	252.03
SMILES Code :	COC1=CC(F)=CC=C1I
MDL No. :	MFCD18396916
InChI Key :	MBHUTPUUHOAWCJ-UHFFFAOYSA-N
Pubchem ID :	56965572

Safety of [ 450-90-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 450-90-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 450-90-8 ]

[ 450-90-8 ] Synthesis Path-Downstream 1~19

1
[ 450-91-9 ]
[ 450-90-8 ]

Yield	Reaction Conditions	Operation in experiment
78%		4-Fluoro-2-methoxyaniline (2.50 g, 17.5 mmol) was dissolved in 14 mL of concentrated HCl, cooled to 0C, solution of NaNO2 (1.45 g, 21.0 mmol) in 13 mL of water was then added under stirring. It was stirred for 40 minutes, resulting solution was added dropwise at room temperature to a solution of KI (8.73 g, 52.6 mmol) in 30 mL of water. Resulting mixture was stirred at 35-40C for 1 hour, product was then extracted with ethyl acetate (3x70 mL), extract was washed with Na2S2O3 solution, dried with Na2SO4. Product was isolated by column chromatography on silica gel using hexane as eluent. Yield of 2-iodo-5-fluoroanysol 5 was 3.46 g (78%) obtained as colourless solid mass.

References: [1]Patent: EP3693365,2020,A1 .Location in patent: Paragraph 0133-0134.
[2]Journal of the Chemical Society,1931,p. 981.

2
[ 741712-36-7 ]
[ 450-90-8 ]
[ 741714-05-6 ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 6549 - 6560.

3
[ 877868-59-2 ]
[ 450-90-8 ]
C₂₀H₁₅NSO₃F₂ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 2643 - 2648.

4
[ 448-19-1 ]
[ 450-90-8 ]

References: [1]Journal of the Chemical Society,1931,p. 981.

5
[ 2265-93-2 ]
[ 865-33-8 ]
[ 20469-63-0 ]
[ 458-51-5 ]
[ 450-90-8 ]

References: [1]Tetrahedron Letters,2009,vol. 50,p. 3776 - 3779.

6
[ 395-82-4 ]
[ 450-90-8 ]