Home Chemistry Organic Building Blocks Fluorinated Building Blocks 2-(2-Fluorophenyl)Acetonitrile
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH2CN).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Reductive Amination: By reducing the nitrile group to an amine, 2-phenylacetonitrile can undergo reductive amination reactions with suitable 【amines|https://www.ambeed.com/amines.html】 or ammonia, resulting in the formation of secondary or tertiary 【amines|https://www.ambeed.com/amines.html】.
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2-(4-Bromo-2,6-difluorophenyl)acetonitrile
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2-(2-Fluoro-6-methoxyphenyl)acetonitrile
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2-(2,6-Difluoro-3-nitrophenyl)acetonitrile
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2-(3-Chloro-2,4-difluorophenyl)acetonitrile
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2-(4-Chloro-2,6-difluorophenyl)acetonitrile
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4-(Cyanomethyl)-2,3,5,6-tetrafluorobenzonitrile
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2-(5-Chloro-2,4-difluorophenyl)acetonitrile
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