Home Chemistry Organic Building Blocks Trifluoromethyls 2-(Trifluoromethoxy)Phenol
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —OCF3,—OH).
Nucleophilic Aromatic Substitution (NAS): In some cases, under appropriate conditions, nucleophiles can attack the benzene ring, leading to nucleophilic aromatic substitution reactions. The trifluoromethoxy group can influence the reactivity of the ring.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.
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2-Hydroxy-3-(trifluoromethoxy)benzamide
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2-Hydroxy-3-(trifluoromethoxy)benzaldehyde
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4-Hydroxy-3-(trifluoromethoxy)benzonitrile
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