Home Chemistry Organic Building Blocks Chlorides 2-Chloro-6-Fluorophenol
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—OH,—F).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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(3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid
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(4-Chloro-2-fluoro-3-hydroxyphenyl)boronic acid
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