Home Chemistry Heterocyclic Building Blocks Pyrroles 2-Phenyl-1H-Pyrrole
Acylation: 2-Phenyl-1H-pyrrole can be acylated by reacting it with acyl chlorides or anhydrides in the presence of a suitable base. This reaction forms an amide.
Amination: It can be subjected to amination reactions by using appropriate aminating agents to introduce amino groups at different positions on the pyrrole ring.
Halogenation: 2-Phenyl-1H-pyrrole can undergo halogenation reactions with various halogenating agents, such as bromine or iodine. These reactions can lead to the introduction of halogen atoms onto the pyrrole ring.
Reduction: Reduction reactions with reducing agents can convert the pyrrole's carbonyl group to the corresponding alcohol.
Oxidation: Oxidation reactions can convert the pyrrole to a pyrrole N-oxide, pyrrole-2-carbaldehyde, or other oxidized derivatives.
Cross-coupling reactions: 2-Phenyl-1H-pyrrole can participate in various cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, to form biaryl compounds or other derivatives.
Grignard reactions: It can react with Grignard reagents to form various organometallic compounds.
Friedel-Crafts reactions: 2-Phenyl-1H-pyrrole can undergo Friedel-Crafts reactions, such as acylation or alkylation, in the presence of Lewis acids like aluminum chloride.
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5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile
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1-(5-(2,4-Difluorophenyl)-2-methyl-1H-pyrrol-3-yl)ethanone
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4-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
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tert-Butyl ((5-(2-fluorophenyl)-1H-pyrrol-3-yl)methyl)(methyl)carbamate
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Methyl 5-(2,4-difluorophenyl)-4-methoxy-1H-pyrrole-3-carboxylate
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5-(3-Chlorophenyl)-1H-pyrrole-2-carboxylic acid
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5-(4-(Isopropylthio)phenyl)-1H-pyrrole-2-carboxylic acid
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5-(4-Isopropoxy-3-methylphenyl)-1H-pyrrole-2-carboxylic acid
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5-(4-Bromophenyl)-1H-pyrrole-2-carboxylic acid
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Ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate
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Ethyl 3-methyl-5-phenyl-1H-pyrrole-2-carboxylate
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3-Methyl-5-phenyl-1H-pyrrole-2-carboxylic acid
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5-(5-Fluoro-2-methoxyphenyl)-3-methyl-1H-pyrrole-2-carboxylic acid
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5-(3,4-Difluorophenyl)-3-methyl-1H-pyrrole-2-carboxylic acid
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Ethyl 5-(3,4-difluorophenyl)-3-methyl-1H-pyrrole-2-carboxylate
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