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Chemical Structure| 928324-56-5 Chemical Structure| 928324-56-5

Structure of 928324-56-5

Chemical Structure| 928324-56-5

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Product Details of [ 928324-56-5 ]

CAS No. :928324-56-5
Formula : C11H7ClFNO
M.W : 223.63
SMILES Code : O=CC1=CNC(C2=CC=CC=C2F)=C1Cl
MDL No. :MFCD27933304
InChI Key :GIVGVEJDOHMXJY-UHFFFAOYSA-N
Pubchem ID :86630973

Safety of [ 928324-56-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 928324-56-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 928324-56-5 ]

[ 928324-56-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 928324-56-5 ]
  • [ 42899-76-3 ]
  • [ 928324-76-9 ]
YieldReaction ConditionsOperation in experiment
78% With 15-crown-5; sodium hydride; In tetrahydrofuran; at 0 - 10℃; for 0.25h; Reference Example 136 5-(2-methylphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde; To a solution of 5-(2-methylphenyl)-1H-pyrrole-3-carbaldehyde (371 mg) in tetrahydrofuran (10 mL) were added sodium hydride (60percent in oil, 288 mg) and 15-crown-5 (1.32 g) at room temperature. After stirring for 5 min, a suspension of <strong>[42899-76-3]pyridine-3-sulfonyl chloride hydrochloride</strong> (642 mg) in N,N-dimethylformamide (5 mL) was added at the same temperature. After stirring for 15 min, ice water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=6:1-->3:1) to give the title compound as a red oil (yield 521 mg, 80percent). 1H-NMR (CDCl3) delta: 1.82 (3H, s), 6.56 (1H, d, J=1.5 Hz), 6.87-6.90 (1H, m), 7.11-7.19 (2H, m), 7.30-7.39 (2H, m), 7.56-7.60 (1H, m), 8.15 (1H, d, J=1.5 Hz), 8.52-8.53 (1H, m), 8.80-8.82 (1H, m), 9.92 (1H, s).
  • 2
  • [ 881674-56-2 ]
  • [ 928324-56-5 ]
YieldReaction ConditionsOperation in experiment
46% With N-chloro-succinimide; In N,N-dimethyl-formamide; at 0 - 60℃; for 2h; Reference Example 114 4-chloro-<strong>[881674-56-2]5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde</strong>; To a solution (15 mL) of <strong>[881674-56-2]5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde</strong> (1.0 g) in N,N-dimethylformamide was added N-chlorosuccinimide (0.71 g) at 0 C., and the mixture was stirred at 60 C. for 2 hr. The mixture was cooled to room temperature, water was added and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=8:1?3:1) to give the title compound as a yellow powder (yield 0.55 g, 46%). 1H-NMR (CDCl3) delta: 7.15-7.40 (3H, m), 7.52 (1H, d, J=3.6 Hz), 7.97-8.03 (1H, m), 9.24 (1H, br), 9.96 (1H, s).
 

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