Home Chemistry Organic Building Blocks Trifluoromethyls 3-(Trifluoromethyl)Benzonitrile
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CF3,—C≡N).
Nucleophilic Aromatic Substitution (SNAr): Depending on the nature of the nucleophile, nucleophilic aromatic substitution reactions can occur. The trifluoromethyl group can influence the reactivity and regioselectivity of these reactions.
Amination: Benzonitrile can be aminated using various reagents to introduce 【amine|https://www.ambeed.com/amines.html】 functional groups.
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3-Cyano-5-(trifluoromethyl)benzoic Acid
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(3-Cyano-5-(trifluoromethyl)phenyl)boronic acid
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2-Hydroxy-5-trifluoromethylbenzonitrile
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2-Methyl-5-(trifluoromethyl)benzonitrile
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2-Amino-5-bromo-3-(trifluoromethyl)benzonitrile
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4-Formyl-3-(trifluoromethyl)benzonitrile
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