Home Chemistry Heterocyclic Building Blocks Pyrrolidines 3-Phenylpyrrolidine
Amine Reactions: 3-Phenylpyrrolidine is itself an amine, and it can undergo typical amine reactions, such as acylation and alkylation. For example, it can react with acyl chlorides to form amides or undergo N-alkylation reactions with alkyl halides to form N-alkylated derivatives.
Reduction: The nitrogen atom in pyrrolidine can be reduced to form a piperidine ring. This can be achieved using reducing agents like lithium aluminum hydride (LiAlH4).
Ring-Opening Reactions: The ring of pyrrolidine can be opened under certain conditions. For example, it can undergo ring-opening reactions with strong acids or nucleophiles, leading to the formation of open-chain compounds.
Aromatic Substitution: The phenyl group attached to pyrrolidine can participate in typical aromatic substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution.
Oxidation: The carbon atoms in the phenyl group can be oxidized using various oxidizing agents to introduce functional groups like hydroxyl groups or carbonyl groups.
Cyclization Reactions: Depending on the reaction conditions and the presence of other functional groups, 3-phenylpyrrolidine can undergo intramolecular cyclization reactions to form various heterocyclic compounds.
Grignard Reactions: The compound can react with Grignard reagents, allowing the introduction of new substituents onto the molecule.
Reactions Involving Electrophiles and Nucleophiles: Like many organic compounds, 3-phenylpyrrolidine can react with various electrophiles and nucleophiles, leading to the formation of different products.
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tert-Butyl (4-(p-tolyl)pyrrolidin-3-yl)carbamate hydrochloride
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3-(2-Methoxyphenyl)pyrrolidine hydrochloride
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1-(tert-Butoxycarbonyl)-4-(3-chlorophenyl)pyrrolidine-3-carboxylic acid
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1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid
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tert-Butyl 3-(2-bromophenyl)pyrrolidine-1-carboxylate
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4-(Pyrrolidin-3-yl)benzoic acid hydrochloride
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2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoic acid
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3-(2-Chlorophenyl)pyrrolidine hydrochloride
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3-(2-Bromophenyl)pyrrolidine hydrochloride
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tert-Butyl 3-phenylpyrrolidine-1-carboxylate
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3-(2,3-Dichlorophenyl)pyrrolidine hydrochloride
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3-(4-Chlorophenyl)pyrrolidine hydrochloride
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3-(3,4-Dichlorophenyl)pyrrolidine hydrochloride
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