Chemistry Heterocyclic Building Blocks Pyrazoles 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine

4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine

Acylation: You can react 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine with acylating agents (e.g., acyl chlorides or anhydrides) to introduce acyl groups onto the nitrogen atoms of the pyrazole ring. Alkylation: You can alkylate the nitrogen atoms in the pyrazole ring using alkylating agents like alkyl halides or alkyl sulfonates. This reaction is often performed in the presence of a base. Dehydration: Under suitable conditions, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine can undergo dehydration reactions to form other pyrazole derivatives. Oxidation: It can be oxidized to form compounds with more highly oxidized nitrogen atoms. Various oxidizing agents can be used for this purpose. Reduction: You can reduce 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine to produce tetrahydropyrazole derivatives using reducing agents like hydrogen and a catalyst. Substitution Reactions: The pyrazole ring can undergo substitution reactions with appropriate nucleophiles or electrophiles, leading to the formation of various substituted derivatives. Cyclization: Depending on the reaction conditions and reagents used, it may undergo intramolecular cyclization reactions to form fused ring systems or other heterocyclic compounds. Functional Group Transformations: You can perform various functional group transformations on 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine to modify its chemical properties or introduce specific functional groups.

Further Reading:

Framework+−

(1-Methyl-1H-Pyrazol-3-Yl)Methanol (1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid 1,3-Dimethyl-1H-Pyrazole 1,3-Diphenyl-1H-Pyrazole 1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole 1,5-Diphenyl-1H-Pyrazole 1-(2-Chlorophenyl)-1H-Pyrazole 1-(3-Chlorophenyl)-1H-Pyrazole 1-(4-Methoxybenzyl)-1H-Pyrazole 1-(Azetidin-3-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole 1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine 1-Benzyl-4-Bromo-1H-Pyrazole 1-Benzyl-4-Iodo-1H-Pyrazole 1-Cyclopentyl-1H-Pyrazole 1-Cyclopropyl-1H-Pyrazole 1-Methyl-1H-Pyrazol-3-Amine 1-Methyl-3-Phenyl-1H-Pyrazole 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole 1-Methyl-5-Phenyl-1H-Pyrazole 1-Phenyl-1H-Pyrazol-3-Amine 1-Phenyl-1H-Pyrazol-3-Ol 1-Phenyl-1H-Pyrazol-5-Amine 1-Phenyl-1H-Pyrazole-3-Carboxylic Acid 1-Phenyl-1H-Pyrazole-4-Carbaldehyde 1-Phenyl-1H-Pyrazole-4-Carbonitrile 1-Phenyl-1H-Pyrazole-4-Carboxylic Acid 1-Phenyl-1H-Pyrazole-5-Carboxylic Acid 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 1-Trityl-1H-Pyrazole 1H-Pyrazol-4-Amine 1H-Pyrazol-4-Ol 1H-Pyrazol-5-Amine 1H-Pyrazole-4-Carbaldehyde 1H-Pyrazole-4-Carbonitrile 1H-Pyrazole-4-Carboxylic Acid 1H-Pyrazole-4-Sulfonyl Chloride 1H-Pyrazole-5-Carboxamide 1H-Pyrazole-5-Carboxylic Acid 1H-Pyrazolo[3,4-B]Pyrazine 1H-Pyrazolo[3,4-B]Pyridin-5-Amine 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,3-Dihydropyrazolo[5,1-B]Oxazole 2,4-Dihydro-3H-Pyrazol-3-One 2,6-Di(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(1H-Pyrazol-3-Yl)Pyridine 2-Phenyl-2,4-Dihydro-3H-Pyrazol-3-One 3-(Tert-Butyl)-1-Phenyl-1H-Pyrazole 3-Bromo-1-Methyl-1H-Pyrazole 3-Bromopyrazolo[1,5-A]Pyridine 3-Bromopyrazolo[1,5-A]Pyrimidine 3-Chloro-1-Methyl-1H-Pyrazole 3-Cyclopropyl-1H-Pyrazole 3-Iodo-1-Methyl-1H-Pyrazole 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine 3-Methyl-1-Phenyl-1H-Pyrazole 3-Phenyl-1H-Pyrazol-5-Amine 4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine 4-(1H-Pyrazol-1-Yl)Benzoic Acid 4-(1H-Pyrazol-1-Yl)Piperidine 4-Bromo-1-Methyl-1H-Pyrazole 4-Bromo-1-Phenyl-1H-Pyrazole 4-Bromo-1H-Pyrazolo[3,4-B]Pyridine 4-Bromopyrazolo[1,5-A]Pyridine 4-Chloro-1H-Pyrazole 4-Chloro-1H-Pyrazolo[3,4-B]Pyridine 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 4-Iodo-1H-Pyrazole 4-Methyl-1-Phenyl-1H-Pyrazole 4-Methyl-1H-Pyrazole 4-Nitro-1H-Pyrazole 4-Phenyl-1H-Pyrazole 5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole 5-(Difluoromethyl)-1H-Pyrazole 5-Bromo-1H-Pyrazole 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine 5-Bromo-1H-Pyrazolo[3,4-C]Pyridine 5-Chloro-1H-Pyrazole 5-Chloro-1H-Pyrazolo[3,4-B]Pyridine 5-Chloropyrazolo[1,5-A]Pyrimidine 5-Cyclopropyl-1H-Pyrazole 5-Iodo-1H-Pyrazole 5-Nitro-1H-Pyrazole 5-Nitro-1H-Pyrazolo[3,4-B]Pyridine 5-Phenyl-1H-Pyrazole-3-Carboxylic Acid 6,7-Dihydro-5H-Pyrazolo[5,1-B][1,3]Oxazine 6-Bromopyrazolo[1,5-A]Pyridine 6-Bromopyrazolo[1,5-A]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 7-Chloropyrazolo[1,5-A]Pyrimidine Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate Ethyl 1H-Pyrazole-4-Carboxylate Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Methyl 1H-Pyrazole-4-Carboxylate Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Pyrazolo[1,5-A]Pyrazine Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Furans Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxetanes Piperazines Piperidines Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinolines Tetrahydrofurans Tetrahydropyrans Thiophenes

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Sulfonyl Chlorides Trifluoromethyls Ureas

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