Home Chemistry Organic Building Blocks Fluorinated Building Blocks 4-Fluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—C≡N).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Sandmeyer Reaction: Benzonitrile can undergo the Sandmeyer reaction, where it is converted to various functional groups using diazonium salts and other reagents.
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4-Fluoro-3-(trifluoromethyl)benzonitrile
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