[ CAS No. 98349-22-5 ] {[proInfo.proName]}

Name: 98349-22-5|2,4,5-Trifluorobenzonitrile|98%
Brand: Ambeed
SKU: A381386
Price: 9.0 USD
Availability: InStock
Rating: 92 (25 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 98349-22-5

Structure of 98349-22-5 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 98349-22-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 98349-22-5 ]

SDS Specification

Alternatived Products of [ 98349-22-5 ]

Product Details of [ 98349-22-5 ]

CAS No. :	98349-22-5	MDL No. :	MFCD00013289
Formula :	C₇H₂F₃N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DLKNOGQOOZFICZ-UHFFFAOYSA-N
M.W :	157.09	Pubchem ID :	593813
Synonyms :

Safety of [ 98349-22-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H312-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 98349-22-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 98349-22-5 ]
Downstream synthetic route of [ 98349-22-5 ]

[ 98349-22-5 ] Synthesis Path-Upstream 1~3

1
[ 6148-64-7 ]
[ 98349-22-5 ]
[ 98349-24-7 ]

Yield	Reaction Conditions	Operation in experiment
80%	Stage #1: With zinc(II) chloride In 1,2-dichloro-ethaneHeating / reflux Stage #2: With hydrogenchloride; water In 1,2-dichloro-ethane at 90℃; for 1 h;	EXAMPLE 3 Preparation of ethyl 2,4,5-trifluorobenzoylacetate To 10 .box. of 1,2-dichloroethane were added 1.0 g of 2,4,5-trifluorobenzonitrile, 0.43 g of zinc chloride, and 1.3 g of potassium ethylmalonate, and then the mixture was stirred at reflux. After the reaction was completed, 11 .box. of 6 N hydrochloric acid was added to the mixture, which then was stirred at reflux at 90° C. for 1 hour. After confirming completion of the reaction by TLC, the solution was cooled to 20° C., and then an organic layer was separated therefrom. The organic layer was concentrated through distillation under reduced pressure. Thus resulted residue was purified by silica gel column chromatography (eluent: ethylacetate/n-hexane= 1/10, v/v) to obtain the title compound in the yield of 80percent (1.2 g). ¹H NMR (400 MHz, CDCl₃) δ Enol Form(75percent): 12.15 (s, 1 H), 7.47 (dd, J=7.8 Hz, 1 H), 7.04 (dd, J=7.8 Hz, 1 H), 5.91 (s, 1 H), 4.26 (q, J=7.2 Hz, 2 H), 1.32 (t, J=7.2 Hz, 3 H). Keto Form (25percent): 7.66 (dd, J=7.8 Hz, 1 H), 7.04 (dd, J=7.8 Hz, 1 H), 4.16 (q, J=7.2 Hz, 2 H), 4.10 (s, 2 H), 1.21 (t, J=7.2 Hz, 3 H). Mass (FAB, m/z): 247 (M+H).

Reference： [1] Patent: US2008/221333, 2008, A1, . Location in patent: Page/Page column 3-4
[2] Patent: WO2007/64077, 2007, A1, . Location in patent: Page/Page column 8

2
[ 98349-22-5 ]
[ 98349-24-7 ]

Reference： [1] Journal of Medicinal Chemistry, 1988, vol. 31, p. 983 - 991

3
[ 98349-22-5 ]
[ 129946-63-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With hydrazine In 1,4-dioxane for 16 h;	2,4,5-Trifluorobenzonitrile (1 g, 6.3 mmol) and hydrazine (610 mg, 19 mmol) were dissolved in dioxane (3 mL) and stirred for 16 h. The reaction mixture was partitioned between ethyl acetate (30 mL) and sat. NaHCO₃(20 mL). The organic layer was washed with brine (10 mL), dried (MgSO₄), filtered and concentrated to give 4-hydrazino-2,5-difluorobenzonitrile (1.012 g, 93percent) as a white solid. LC/MS: m/z (M+H)=170.0. ¹H-NMR (400 MHz, DMSO-d₆) δ (ppm): 4.41 (2H, br s), 6.93 (1H, dd), 7.51 (1H, dd), 8.22 (1H, br s).

Reference： [1] Patent: US2008/269193, 2008, A1, . Location in patent: Page/Page column 40
[2] Patent: US5006148, 1991, A,
[3] Patent: US6906006, 2005, B1,

[ 98349-22-5 ] Synthesis Path-Downstream 1~61

1
[ 98349-22-5 ]
[ 112279-61-5 ]

Yield	Reaction Conditions	Operation in experiment
100%	With ammonia at 60℃; for 4.5h;
	With ammonia In tetrahydrofuran; water	1 EXAMPLE 1 EXAMPLE 1 515 g of 2,4,5-trifluorobenzonitrile in 2000 ml of tetrahydrofuran are introduced into an autoclave and heated to 100° C. 250 ml of liquid ammonia are then pumped in at such a rate that the temperature remains in the range from 100 to 105° C. The mixture is then stirred at this temperature for 8 h and then cooled. The pressure reaches a maximum of 22 bar gauge. After the ammonia has been blown off, the solvent is removed using a rotary evaporator. The residue is stirred into 500 ml of water and placed on a suction filter. After filtering with suction, the residue is again slurried with 200 ml of water and filtered with suction. Drying in a vacuum at 40° C. gives 482 g (95.4% of theory) of 4-cyano-2,5-difluoroaniline having a melting point of from 99 to 100° C.
	With ammonia at 60℃; for 4h;	Step A: 4-amino-2,5-difluorobenzonitrile: 2, 4, 5-trifluorobenzonitrile (20 g, 127 mmol) was added to 15 mL of liquid NH3 and was reacted under 1.4 MPa at 60°C for 4 hours. The reaction mixture was then cooled to room temperature, diluted with ether (200 mL), washed with brine, dried and concentrated to give 4-amino-2,5-difluorobenzonitrile.

With ammonium hydroxide at 130℃; for 6h; High pressure; Autoclave;

Reference： [1]Bridges, Alexander J.; Zhou, Hairong [Journal of Heterocyclic Chemistry, 1997, vol. 34, # 4, p. 1163 - 1172]
[2]Current Patent Assignee: BAYER AG - US6075160, 2000, A
[3]Current Patent Assignee: MERCK & CO INC - WO2016/60941, 2016, A1 Location in patent: Page/Page column 45
[4]Chen, Qiang; Gou, Kun; Li, Chungen; Liu, Huan; Liu, Xiaocong; Luo, Youfu; Luo, Yuan; Tao, Lei; Yang, Xiaowei; Yang, Xinyu; Zeng, Ting; Zhao, Yinglan; Zhong, Xi; Zhou, Xia; Zhou, Yue [Journal of Medicinal Chemistry, 2021, vol. 64, # 24, p. 18175 - 18192]

2
[ 1074-82-4 ]
[ 98349-22-5 ]
[ 958031-87-3 ]

Yield	Reaction Conditions	Operation in experiment
85%	In N,N-dimethyl-formamide at 100℃; for 5h;	7.1 To a 100 ml DMF solution of 16.0 g (101.6 mmol) of 2, 4, 5-trifluorobenzonitrile was added 20.0 g (108.0 mmol) of potassium phthalimide, and the mixture was heated at 1000C while stirring for 5 hours. After cooling, the reaction solution was poured into ice water, and extracted with an ethyl acetate, THF mixed solvent, and the solvent was distilled off under reduced pressure. The remaining crystal was washed with a small amount of ethyl acetate to obtain 24.7 g of the aimed compound in the form of white crystal (yield: 85%) .

Reference： [1]Current Patent Assignee: BAYER AG - WO2007/131680, 2007, A1 Location in patent: Page/Page column 83

3
[ 98349-22-5 ]
[ 168644-93-7 ]

Reference： [1]Organic Letters,1999,vol. 1,p. 183 - 185

4
[ 13375-57-0 ]
[ 98349-22-5 ]
[ 946388-40-5 ]

Yield	Reaction Conditions	Operation in experiment
65%	In dimethyl sulfoxide at 120℃; for 4h;

Reference： [1]Perner, Richard J.; DiDomenico, Stanley; Koenig, John R.; Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Drizin, Irene; Guo, Zhu Zheng; Turner, Sean C.; Jinkerson, Tammie; Brown, Brian S.; Keddy, Ryan G.; Lukin, Kurill; McDonald, Heath A.; Honore, Prisca; Mikusa, Joe; Marsh, Kennan C.; Wetter, Jill M.; St. George, Karen; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung [Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3651 - 3660]

5
[ 6760-99-2 ]
[ 98349-22-5 ]
C₁₄H₁₄F₂N₂ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 3651 - 3660

6
[ 98349-22-5 ]
[ 100-51-6 ]
4-(benzyloxy)-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With potassium <i>tert</i>-butylate In tetrahydrofuran at -78 - 20℃; for 24.75h;
67.3%	Stage #1: benzyl alcohol With potassium <i>tert</i>-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran at -78 - 20℃; for 24.5h; Inert atmosphere;	1 (2S)-N-[[5-Fluoro-4-[(3-fluorophenyl)methoxy]-2-methoxy-phenyl]methyl]pyrrolidine-2-carboxamide and its fumaric acid addition salt Potassium 2-methylpropan-2-olate (7.86 g, 70.0 mmol) was suspended in THF (80 mL) and the mixture was cooled to 0°C. Phenylmethanol (13.77 g, 127 mmol) wasadded and the solution was stirred at 0°C for 30min followed by dropwise addition to2,4,5-trifluorobenzonitrile (10 g, 63.7 mmol) in THF(80 mL) at -78 oc under nitrogen.The solution was stirred at -78 oc for 3h, warmed to room temperature over 1.5h andstirred at RT for 20h. The solution was diluted with EtOAc (500 mL) and washed with water (270 mL). The water phases were re-extracted with DCM (100 mL 2) and thecombined organic phases were concentrated to give crude product, which was recrystallizedfrom EtOH and resulted in 4-(benzyloxy)-2,5-difluorobenzonitrile (10.5 g, 42.8mmol, 67.3% yield).

Reference： [1]Wallner, Fredrik K.; Spjut, Sara; Bostroem, Dan; Elofsson, Mikael [Organic and Biomolecular Chemistry, 2007, vol. 5, # 15, p. 2464 - 2471]
[2]Current Patent Assignee: ABBVIE INC - WO2018/175449, 2018, A1 Location in patent: Page/Page column 65

7
[ 98349-22-5 ]
[ 430459-89-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 9 steps 1.1: 95 percent / methanol / 48 h / Heating 2.1: 93 percent / NaOH / methanol; H₂O / Heating 3.1: oxalyl chloride / CH₂Cl₂ / 20 °C 4.1: AlCl₃ / CH₂Cl₂ / 68 h / 0 - 20 °C 5.1: 3.3 g / aq. HCl / 0 °C 6.1: 83 percent / H₂O / 3 h / 200 - 220 °C 7.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 7.2: 65 percent / tetrahydrofuran / 20 °C 8.1: tBuLi / tetrahydrofuran; pentane; various solvent(s) / 0.25 h / -105 °C 8.2: 69 percent / tetrahydrofuran; pentane; various solvent(s) / 0.5 h / -105 °C 9.1: 78 percent / H₂ / Pd/C / aq. ethanol; ethyl acetate / 20 °C / 760.05 Torr

Reference： [1]Chen, Chien-An; Yeh, Ren-Hwa; Lawrence, David S. [Journal of the American Chemical Society, 2002, vol. 124, # 15, p. 3840 - 3841]

8
[ 98349-22-5 ]
[ 430459-82-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 11 steps 1.1: 95 percent / methanol / 48 h / Heating 2.1: 93 percent / NaOH / methanol; H₂O / Heating 3.1: oxalyl chloride / CH₂Cl₂ / 20 °C 4.1: AlCl₃ / CH₂Cl₂ / 68 h / 0 - 20 °C 5.1: 3.3 g / aq. HCl / 0 °C 6.1: 83 percent / H₂O / 3 h / 200 - 220 °C 7.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 7.2: 65 percent / tetrahydrofuran / 20 °C 8.1: tBuLi / tetrahydrofuran; pentane; various solvent(s) / 0.25 h / -105 °C 8.2: 69 percent / tetrahydrofuran; pentane; various solvent(s) / 0.5 h / -105 °C 9.1: 78 percent / H₂ / Pd/C / aq. ethanol; ethyl acetate / 20 °C / 760.05 Torr 10.1: NaH / dimethylformamide / 0.5 h / 0 °C 10.2: 76 percent / dimethylformamide / 20 °C 11.1: 89 percent / H₂ / Pd/C / aq. ethanol; ethyl acetate / 20 °C / 760.05 Torr

Reference： [1]Chen, Chien-An; Yeh, Ren-Hwa; Lawrence, David S. [Journal of the American Chemical Society, 2002, vol. 124, # 15, p. 3840 - 3841]

9
[ 3179-31-5 ]
[ 98349-22-5 ]
[ 169455-30-5 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In methanol	III.1 Starting substance of the formula (III): Example (III-1) STR11 Starting substance of the formula (III): Example (III-1) STR11 A mixture of 5.3 g (52 mmol) of 3-mercapto-1H-1,2,4-triazole, 8.2 g (52 mmol) of 2,4,5-trifluoro-benzonitrile, 2.8 g (52 mmol) of sodium methanolate and 50 ml of methanol is stirred for 15 hours at 20° C. and then for a further 12 hours at 60° C. and for 8 hours under reflux. After the mixture has been concentrated to approximately half its volume and cooled, the product which has precipitated in crystalline form is isolated by filtration. 4.0 g (32% of theory) of 3-(4-cyano-2,5-difluoro-phenylthio)-1H-1,2,4-triazole of melting point 185° C. are obtained.
	With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;

Reference： [1]Current Patent Assignee: BAYER AG - US5496793, 1996, A
[2]Current Patent Assignee: EISAI CO LTD - EP1258480, 2002, A1 Location in patent: Page 29

10
[ 773837-37-9 ]
benzenediazonium sulphate [ No CAS ]
[ 98349-22-5 ]

Yield	Reaction Conditions	Operation in experiment
	In water at 5℃; for 0.25h;	1 PREPARATION EXAMPLES; EXAMPLE 1 PREPARATION EXAMPLES EXAMPLE 1 4.4 g (30 mmol) of 2,4,5-trifluoro-aniline are dissolved in 25 ml of acetic acid ("glacial acetic acid") and cooled using an ice-bath.. With stirring, 4.5 g (31.5 mmol) of nitrosylsulphuric acid are then added, the ice-bath is removed and the reaction mixture is stirred for an additional hour (first step). With stirring, the resulting diazonium salt solution is then added to a solution, cooled to 5° C., of 7.8 g (160 mmol) of sodium cyanide and 0.3 g (3 mmol) of copper(I) cyanide in 40 ml of water.. By simultaneous addition of approximately 80 ml of a 25% strength aqueous solution of sodium carbonate, the PH is maintained approximately in the neutral range.. The reaction mixture is subsequently stirred for approximately another 15 minutes and then extracted twice with 100 ml of ethyl acetate each time.. The solvent is carefully distilled off under water pump vacuum from the combined organic extraction solutions. This gives 4.1 g (92% pure product according to gas chromatographic analysis, i.e. 80% of theory) of 2,4,5-trifluoro-benzonitrile as an oily residue.

Reference： [1]Current Patent Assignee: BAYER AG - US6399807, 2002, B1 Location in patent: Page column 4

11
[ 98349-22-5 ]
[ 38216-72-7 ]
tert-butyl 4-(4-cyano-2,5-difluorophenyl)piperazine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 18h;	Step 1: Combine 2,4,5-trifluorobenzonitrile (2.50 g, 15.9 mmol), N-Boc-piperazine (2.96 g, 15.9 mmol) and K2CO3 (2.63 g, 19.1 mmol) in DMF (20 ml). Stir 18 h and partition between ether and water. Wash with brine, dry (MgSO4), concentrate and chromatograph on silica to obtain the piperazine as a white solid

Reference： [1]Patent: US2004/220194,2004,A1 .Location in patent: Page 31

12
[ 50541-93-0 ]
[ 98349-22-5 ]
[ 609789-84-6 ]

Yield	Reaction Conditions	Operation in experiment
83%	With potassium carbonate In DMF (N,N-dimethyl-formamide) at 0 - 20℃;	164.a Example 164; Synthesis of 4-[(1-benzylpiperidin-4-yl)amino]-2,5-difluorobenzamide; (a) Synthesis of 4-[(1-benzylpiperidin-4-yl)amino]-2,5-difluorobenzonitrile (a) Synthesis of 4-[(1-benzylpiperidin-4-yl)amino]-2,5-difluorobenzonitrile Potassium carbonate (2.64 g, 19.1 mmol) was added to a solution of 2,4,5-trifluorobenzonitrile (1.00 g, 6.4 mmol) in N,N-dimethylformamide (30 ml), and the resulting mixture was ice-cooled, followed by adding thereto 4-amino-1-benzylpiperidine (1.36 ml, 6.7 mmol). The resulting mixture was slowly warmed up to room temperature and stirred overnight. The reaction solution was added to a saturated aqueous sodium hydrogencarbonate solution and extracted three times with toluene/ethyl acetate = 1/1, and the combined organic layer was washed once with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off and the solid precipitated was suspended in hexane/diethyl ether to be washed. The washed solid was collected by filtration and dried under reduced pressure to obtain 4-[(1-benzylpiperidin-4-yl)amino]-2,5-difluorobenzonitrile (1.749 g, 83%).

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem); Sumitomo Pharma (in: Sumitomo Chemical) - EP1500643, 2005, A1 Location in patent: Page 72

13
trans-4-(tert-butoxycarbonylamino)cyclohexylamine [ No CAS ]
[ 98349-22-5 ]
tert-butyl (trans-4-[(4-cyano-2,5-difluorophenyl)amino]cyclohexyl)carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With potassium carbonate In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 3h;	158.a Example 158; Synthesis of 4-[(trans-4-aminocyclohexyl)amino]-5-fluoro-2-methoxybenzamide; (a) Synthesis of tert-butyl (trans-4-[(4-cyano-2,5-difluorophenyl)amino]cyclohexyl)carbamate (a) Synthesis of tert-butyl (trans-4-[(4-cyano-2,5-difluorophenyl)amino]cyclohexyl)carbamate Potassium carbonate (2.63 g, 19.1 mmol) was added to a solution of 2,4,5-trifluorobenzonitrile (1.0 g, 6.37 mmol) in dimethylformamide (20 mL), and a solution of trans-tert-butyl 4-aminocyclohexylcarbamate (1.50 g, 7.0 mmol) in dimethylformamide (10 mL) was quickly dropped thereinto with stirring under ice-cooling. The resulting mixture was warmed up to room temperature and then stirred for another 3 hours. A saturated aqueous sodium chloride solution and a saturated aqueous sodium hydrogencarbonate solution were added to the reaction solution, followed by extraction with ethyl acetate (twice), and the organic layer was washed with a saturated aqueous sodium chloride solution. The washed organic layer was dried over magnesium sulfate and distilled under reduced pressure to remove the solvent, and the resulting residue was washed with diethyl ether-hexane to obtain tert-butyl (trans-4-[(4-cyano-2,5-difluorophenyl)amino]cyclohexyl)carbamate (1.1 g, 50%) as white powder.

Reference： [1]Current Patent Assignee: Sumitomo Pharma (in: Sumitomo Chemical); Sumitomo Chemical (w/o Dongwoo Fine-Chem); SUMITOMO CHEMICAL COMPANY LIMITED - EP1500643, 2005, A1 Location in patent: Page 69

14
[ 799557-70-3 ]
[ 98349-22-5 ]
1-isopropyl-4-[1-(4-cyano-2,5-difluorophenyl)-piperidine-4-carbonyl]-[1,4]diazepane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In dimethyl sulfoxide at 140℃; for 2h;	39 Example 39; 1-ISOPROPYL-4- [1- (4-CYANO-2, 5-DIFLUOROPHENYL)-PIPERIDINE-4-CARBONYL]- [1, 4] - diazepane hydrochloride (E39) K2CO3 (0.5g) was added to a solution of 1-ISOPROPYL-4- (PIPERIDINE-4-CARBONYL]- [1, 4] - diazepane (D8) (0.2g) in dry DMSO (2ml), and the resulting mixture was stirred at rt for 15min, followed by the addition of 2,4, 5-TRIFLUOROBENZONITRILE (0.24g) in dry DMF (1 ML). The reaction was then heated at 140°C for 2h before cooling to rt. Excess potassium carbonate was removed by filtration and the crude reaction mixture was purified first by adding the crude reaction to a Varian 10G SCX column and eluting with MEOH (40MOI), then eluting with 10% 0.88 ammonia solution in MEOH (20ML) which was evaporated to afford a residue that was further purified using a Waters mass directed auto preparative HPLC. The purified fractions were combined and the aqueous solvents were removed by evaporation and the residue re-dissolved in MEOH (2ML) and treated with 1 N ethereal HCI (1 ML) which gave a white solid which was washed with diethyl ether to give the title compound (E39) (34MG). H NMR 5 [MeOH-d4]; 1.37 (6H, m), 1.87 (4H, m), 2.19-2. 29 (2H, m), 2.94-3. 00 (3H, m), 3.29-3. 3 (2H, m), 3.53-3. 58 (7H, m), 3.86-3. 98 (1 H, m), 4.04- 4.1 (1H, m), 6.9 (1H, dd, J=11. 6Hz), 7.4 (1H, dd, J=12.4hZ). LCMS electrospray (+ve) 391 (MH+).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2004/101546, 2004, A1 Location in patent: Page 39-40

15
[ 845305-85-3 ]
[ 98349-22-5 ]
4-{4-[(1-cyclobutyl-4-piperidinyl)oxy]-1-piperidinyl}-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In dimethyl sulfoxide at 80℃; for 0.0833333h; Microwave irradiation;	117 Example 117 4- {4- [ (1-CYCLOBUTYL-4-PIPERIDINYL) OXY]-1-PIPERIDINYL}-2, 5-DIFLUOROBENZONITRILE (E117) 1-CYCLOBUTYL-4- (4-PIPERIDINYLOXY) PIPERIDINE (D6) (0.200g), 2,4, 5-TRIFLUOROBENZONITRILE (0. 198G) and anhydrous potassium carbonate (0.232g) in DMSO (2ML) were heated at 80°C for 5min in an EMRYS OPTIMIZER microwave reactor. The crude reaction mixture was passed through an SCX cartridge [20g, eluting with MeOH (80ML) then 2N NH3 in MeOH (80ML)]. Evaporation of the ammonia fractions gave the title compound (E117) as a crystalline solid (0.33g). MS electrospray (+ion) 376 (MH+). 1 H NMR 8 (CDCl3) : 7.18- 7.13 (1H, app q, J=6. 0Hz), 6.30 (1H, dd, H=11. 2,7. 2Hz), 3.64 (1H, app sept, J=4Hz), 3.51-3. 45 (3H, m), 3.16 (2H, ddd, J=12. 0,8. 4,3. 6Hz), 2.75-2. 62 (3H, m), 2.07-1. 99 (4H, m), 1.97-1. 85 (6H, m) and 1.80-1. 60 (6H, m).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2005/14571, 2005, A1 Location in patent: Page/Page column 62-63

16
[ 98349-22-5 ]
[ 50650-59-4 ]
[ 390412-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80℃; for 13h;	Example 22 2,5-Difluoro-4-[2-oxo-4-(trifluoromethyl)-1-(2H)-pyridinyl)]benzonitrile 7.6 g (55.5 mmol) of potassium carbonate were added to a solution of 8.1 g (50 mmol) of <strong>[50650-59-4]4-(trifluoromethyl)-2-pyridone</strong> in 100 ml of dimethylformamide. At room temperature, a solution of 8.6 g (55 mmol) of 2,4,5-trifluorobenzonitrile in 10 ml of dimethylformamide was then added. The mixture was heated at 80 C. for a total of 13 h. After cooling, the reaction mixture was concentrated under reduced pressure, the residue was dissolved in 400 ml of methyl tert-butyl ether and the organic phase was washed twice with water, dried over magnesium sulfate and treated under reduced pressure. The resulting crude product was purified by silica gel chromatography using a cyclohexane/ethyl acetate gradient (4:1 to 1:2). This gave 9.6 g of the title compound of melting point 150 C. The 1H-NMR data of the compound are listed in Table 4.

Reference： [1]Patent: US2003/216257,2003,A1 .Location in patent: Page/Page column 36-37

17
[ 461-89-2 ]
[ 98349-22-5 ]
[ 195524-88-0 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In water; dimethyl sulfoxide;	Step 3 56.5 g (0.5 mol) of <strong>[461-89-2]6-aza-uracil</strong> in 600 ml of dimethyl sulphoxide are admixed with 69 g (0.5 mol) of potassium carbonate and 83.2 g (0.53 mol) of 2,4,5-trifluorobenzonitrile, and the mixture is stirred at from 70 C. to 80 C. for 10 hours. The mixture is then concentrated to about 1/3 of its original volume using a rotary evaporator, the residue is stirred with water and acidified with conc. hydrochloric acid and the precipitated product is filtered off with suction, washed with water and then with ethanol. This gives 116 g (92.8% of theory) of 2-(2,5-difluoro-4-cyano-phenyl)-<strong>[461-89-2]1,2,4-triazine-3,5(2H,4H)-dione</strong> of melting point >250 C. logP (pH 2): 1.45

Reference： [1]Patent: US2003/69140,2003,A1

18
[ 94248-99-4 ]
[ 98349-22-5 ]
[ 186142-38-1 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In water; dimethyl sulfoxide;	Example 1 20 g (0.10 mol) of <strong>[94248-99-4]3-methyl-pyridazine-6-one hydrobromide</strong> and 30 g (0.22 mol) of potassium carbonate are initially charged in 200 ml of dimethyl sulphoxide, and 15.7 g (0.10 mol) of 2,4,5-trifluorobenzonitrile are added at room temperature (about 20 C.). The mixture is stirred at 40 C.-50 C. overnight and subsequently concentrated using a rotary evaporator. The residue is stirred with water, filtered off with suction and recrystallized from isopropanol. 18.5 g (76% of theory) of 2-(2,5-difluoro-4-cyano-phenyl)-6-methyl-pyridazin-3-one of melting point 159 C. are obtained.

Reference： [1]Patent: US6551963,2003,B1

19
[ 98349-22-5 ]
[ 63910-43-0 ]
[ 186142-39-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In dimethyl sulfoxide;	Example 2 5.0 g (0.03 mol) of <strong>[63910-43-0]5-chloro-4-methoxy-pyridazine-6-one</strong> and 5.0 g of potassium carbonate are initially charged in 50 ml of dimethyl sulphoxide, and 4.7 g (0.03 mol) of 2,4,5-trifluoro-benzonitrile are added at room temperature (about 20 C.). The mixture is stirred at room temperature for 2 hours and then poured into water, and precipitated product is filtered off with suction, washed with water and dried. 7.7 g (86% of theory) of 2-(2,5-difluoro-4-cyano-phenyl)-4-chloro-5-methoxy-pyridazin-3-one of melting point 182 C. are obtained.

Reference： [1]Patent: US6551963,2003,B1

20
[ 51856-10-1 ]
[ 98349-22-5 ]
[ 157277-61-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In water; dimethyl sulfoxide	II.1 Example II-1 STR191 5.8 g (0.042 mol) of potassium carbonate are added at room temperature to 6.3 g (0.034 mol) of 4-methyl-3-trifluoromethyl-1,2,4-triazolin-5-one (cf. e.g. U.S. Pat. No. 3,780,052) and 5.4 g (0.034 mol) of 2,4,5-trifluorobenzonitrile (cf. e.g. EP 191181) in 150 ml of dimethyl sulphoxide and the mixture is subsequently heated at 100° C. for 14 hours. For working up, the cooled reaction mixture is placed in water, adjusted to a pH of 2 with dilute hydrochloric acid and subjected several times to extraction with dichloromethane. The combined organic phases are dried over sodium sulphate and concentrated in vacuo. The residue is chromatographed over silica gel (eluent:dichloromethane). 6.2 g (60% of theory) of 1-(4-cyano-2,5-difluorophenyl)4methyl-3-trifluoromethyl-1,2,4-triazolin-5-one are obtained of melting point 74° C.
	With hydrogenchloride; potassium carbonate In water; dimethyl sulfoxide	IV.1 Example IV-1 STR76 5.8 g (0.042 mol) of potassium carbonate are added to 6.3 g (0.034 mol) of 4-methyl-3-trifluoromethyl-1,2,4-triazolin-5-one (cf. for example U.S. Pat. No. 3,780,052) and 5.4 g (0.034 mol) of 2,4,5-trifluorobenzonitrile (cf. for example EP 191181) in 150 ml of dimethyl sulphoxide at room temperature, and the mixture is subsequently heated for 14 hours at 100° C. Workup is by adding the cooled reaction mixture to water, adjusting the pH to 2 using dilute hydrochloric acid and extracting a number of times with dichloromethane. The combined organic phases are dried over sodium sulphate and concentrated in vacuo. The residue is chromatographed on silica gel (eluent: dichloromethane). 6.2 g (60% of theory) of 1-(4-cyano-2,5-difluorophenyl)-4-methyl-3-trifluoromethyl-1,2,4-triazolin-5-one are obtained, having a melting point of 74° C.

Reference： [1]Current Patent Assignee: BAYER AG - US6077813, 2000, A
[2]Current Patent Assignee: BAYER AG - US5464810, 1995, A

21
[ 932-53-6 ]
[ 98349-22-5 ]
2-(2,4-difluoro-4-cyano-phenyl)-6-methyl-1,2,4-triazine-3,5(2H,4H)-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; potassium carbonate; In water; dimethyl sulfoxide;	STR122 At 120 C., 2.54 g (20 mMol) of <strong>[932-53-6]6-methyl-1,2,4-triazine-3,5(2H,4H)-dione</strong> in 50 ml of dimethyl sulphoxide are stirred with 2.8 g (20 mMol) of potassium carbonate and 3.14 g (20 mol) of 2,4,5-trifluoro-benzonitrile for 12 hours, the mixture is subsequently cooled to room temperature and stirred with water, the pH is adjusted to using hydrochloric acid and precipitated product is filtered off with suction, stirred with water and dried. 4.6 g (87% of theory) of 2-(2,4 -difluoro-4-cyano-phenyl)-<strong>[932-53-6]6-methyl-1,2,4-triazine-3,5(2H,4H)-dione</strong> of melting point 214 C. are obtained.

Reference： [1]Patent: US6159903,2000,A

22
[ 98349-22-5 ]
[ 129946-63-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With hydrazine; In 1,4-dioxane; for 16.0h;	2,4,5-Trifluorobenzonitrile (1 g, 6.3 mmol) and hydrazine (610 mg, 19 mmol) were dissolved in dioxane (3 mL) and stirred for 16 h. The reaction mixture was partitioned between ethyl acetate (30 mL) and sat. NaHCO3 (20 mL). The organic layer was washed with brine (10 mL), dried (MgSO4), filtered and concentrated to give 4-hydrazino-2,5-difluorobenzonitrile (1.012 g, 93%) as a white solid. LC/MS: m/z (M+H)=170.0. 1H-NMR (400 MHz, DMSO-d6) delta (ppm): 4.41 (2H, br s), 6.93 (1H, dd), 7.51 (1H, dd), 8.22 (1H, br s).
	With hydrazine hydrate; In ethanol; water;	STR112 11 g (0.22 mol) of hydrazine hydrate are added to 30 g (0.19 mol) of 2,4,5-trifluorobenzonitrile (cf., for example, EP-A 191,181) in 120 ml of ethanol, the mixture is heated at reflux temperature for 2 hours, cooled to room temperature and concentrated in vacuo, the residue is stirred with 50 ml of water, and any product which has precipitated is filtered off with suction and dried. 24 g (75% of theory) of 4-cyano-2,5-difluorophenylhydrazine of melting point 158 C. are obtained.
	With hydrazine hydrate; In ethanol; water;	Example II-1 11 g (0.22 mol) of hydrazine hydrate are added to 30 g (0.19 mol) of 2,4,5-trifluorobenzonitrile (cf., for example, EP-A 191,181) in 120 ml of ethanol, the mixture is heated at reflux temperature for 2 hours, cooled to room temperature and concentrated in vacuo, the residue is stirred with 50 ml of water, and any product which has precipitated is filtered off with suction and dried. 24 g (75% of theory) of 4-cyano-2,5-difluorophenylhydrazine of melting point 158 C. are obtained.

Reference： [1]Patent: US2008/269193,2008,A1 .Location in patent: Page/Page column 40
[2]Patent: US5006148,1991,A
[3]Patent: US6906006,2005,B1

23
[ 98349-22-5 ]
5-[4-(4-cyano-2,5-difluorophenoxy)piperidin-1-yl]-5-methyl-2,2-diphenylhexanoic acid amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	Stage #1: 5-(4-hydroxypiperidin-1-yl)-5-methyl-2,2-diphenylhexanamide With sodium hydride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran at -70 - 20℃; for 21h; Stage #3: With water In tetrahydrofuran	94 Sodium hydride (60% dispersion in mineral oil, 12mg, 0.29mmol) was added to a solution of the product of preparation 54 (100mg, 0.26mmol) in tetrahydrofuran (0.5mL) at room temperature and allowed to stir for 20 minutes before cooling to -700C. The mixture was added into a solution of 2,4,5-trifluorobenzonitrile (41 mg, 0.26mmol) in tetrahydrofuran (0.5mL) at -700C and stirred for 3 hours. The reaction was then allowed to warm to room temperature and stirred for a further 18 hours. The reaction was quenched with water (5 drops) and the solvent evaporated in vacuo. The residue was partitioned between ethyl acetate (4OmL) and water (2OmL), the organic layer was separated and washed with brine (2OmL). The organic phase was dried over magnesium sulfate, concentrated in vacuo and the residue purified by column chromatography on silica gel, eluting with dichloromethane:methanol:0.88 ammonia, 100:0:0 to 90:10:1. The appropriate fractions were evaporated under reduced pressure to afford the title compound as a colourless glass in 40% yield, 54mg.1HNMR(400MHz, CD3OD) δ: 0.99(8, 6H), 1.25-1.29(m, 2H), 1.66-1.75(m, 2H), 1.92-1.97(m, 2H) 2.25-2.30(m, 2H) 2.42-2.46(m, 2H), 4.43-4.49(m, 1H), 7.13-7.52(m, 12H); LRMS APCI m/z 518 [M+H]+

Reference： [1]Current Patent Assignee: PFIZER INC - WO2007/34325, 2007, A1 Location in patent: Page/Page column 121-122

24
[ 98349-22-5 ]
[ 933773-13-8 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: [2-(4-trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1-ylmethyl)-thiazol-5-yl]-methanol With potassium <i>tert</i>-butylate In tetrahydrofuran; <i>tert</i>-butyl alcohol at 5℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran; <i>tert</i>-butyl alcohol at -60 - 20℃;	C.99 To a solution of 800 mg of [2-(4-trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1- ylmethyl)-thiazol-5-yl]-methanol in 4 mL of tetrahydrofuran at 5°C was slowly added 2.13 mL of a molar solution of potassium tert-butoxide in tert-butanol. After stirring at 5°C for 30 minutes, the resulting solution was slowly added to a solution of 296 mg of 2,4,5-trifluoro-benzonitrile in 1 mL of tetrahydrofuran at -60°C. The resulting mixture was stirred for 1 h at -600C then stirred overnight allowing the temperature to warm up to room temperature. It was then poured into water and extracted with dichloromethane. The organic extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was recrystallized from methanol and washed with diisopropyl ether to give 890 mg of 2,5-difluoro-4-[2-(4-trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1-ylmethyl)-thiazol-5-ylmethoxy]- benzonitrile.C25H19F8N3OS (561.50), MS(ESI): 563.1 (M+H+).

Reference： [1]Current Patent Assignee: SANOFI - WO2007/39172, 2007, A1 Location in patent: Page/Page column 257-259

25
[ 6148-64-7 ]
[ 98349-22-5 ]
[ 98349-24-7 ]

Yield	Reaction Conditions	Operation in experiment
80%		EXAMPLE 3 Preparation of ethyl 2,4,5-trifluorobenzoylacetate To 10 of 1,2-dichloroethane were added 1.0 g of 2,4,5-trifluorobenzonitrile, 0.43 g of zinc chloride, and 1.3 g of potassium ethylmalonate, and then the mixture was stirred at reflux. After the reaction was completed, 11 of 6 N hydrochloric acid was added to the mixture, which then was stirred at reflux at 90 C. for 1 hour. After confirming completion of the reaction by TLC, the solution was cooled to 20 C., and then an organic layer was separated therefrom. The organic layer was concentrated through distillation under reduced pressure. Thus resulted residue was purified by silica gel column chromatography (eluent: ethylacetate/n-hexane= 1/10, v/v) to obtain the title compound in the yield of 80% (1.2 g). 1H NMR (400 MHz, CDCl3) delta Enol Form(75%): 12.15 (s, 1 H), 7.47 (dd, J=7.8 Hz, 1 H), 7.04 (dd, J=7.8 Hz, 1 H), 5.91 (s, 1 H), 4.26 (q, J=7.2 Hz, 2 H), 1.32 (t, J=7.2 Hz, 3 H). Keto Form (25%): 7.66 (dd, J=7.8 Hz, 1 H), 7.04 (dd, J=7.8 Hz, 1 H), 4.16 (q, J=7.2 Hz, 2 H), 4.10 (s, 2 H), 1.21 (t, J=7.2 Hz, 3 H). Mass (FAB, m/z): 247 (M+H).

Reference： [1]Patent: US2008/221333,2008,A1 .Location in patent: Page/Page column 3-4
[2]Patent: WO2007/64077,2007,A1 .Location in patent: Page/Page column 8

26
[ 98349-22-5 ]
[ 33577-16-1 ]
[ 433940-01-3 ]

Yield	Reaction Conditions	Operation in experiment
84%	Stage #1: methyl methylsulfinylmethyl sulfide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran; hexane at -78 - 20℃; for 0.55 - 0.583333h;	41.i (i) 2,5-Difluoro-4[(methylsulfinyl)(methylthio)methyl]benzonitrile (Methylsulfinyl)(methylthio)methane (3.16 g, 0.0255 mol) was dissolved in 50 mL of dry THF under argon and then cooled to -78° C. Butyllithium in hexane (16 mL 1.6M, 0.0256 mol) was added dropwise with stirring. The mixture was stirred for 15 min. Meanwhile a solution of 2,4,5-trifluorobenzonitrile (2.0 g; 0.013 mol) in 50 mL of dry THF was cooled to -78° C. under argon and the former solution was added through a cannula to the latter solution over a period of 3-5 min. After 30 min, the cooling bath was removed and when the reaction had reached room temperature it was poured into 200 mL of water. The THF was evaporated and the remaining aqueous layer was extracted three times with diethyl ether. The combined ether phase was washed with water, dried (Na2SO4) and evaporated. The crude product started to crystallise and could be used as such in the next step. Yield: 2.8 g (84%). 1H NMR (500 MHz, CDCl3) δ7.51-7.44 (m, 2H, major diastereomer), 7.39 (dd, 1H, minor diastereomer), 5.00 (s, 1H, minor diastereomer), 4.92 (s, 1H, major diastereomer), 2.59 (s, 3H, minor diastereomer), 2.56 (s, 1H, major diastereomer), 2.46 (s, 1H, minor diastereomer), 2.40 (s, 1H, major diastereomer)
84%	Stage #1: methyl methylsulfinylmethyl sulfide With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran; hexane at -78 - 20℃;	41.i Example 41; Ph(3-CI)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab(2,6-diF); (i) 2,5-Difluoro-4[(methylsulfinyl)(methylthio)methyl]benzonitrile (Methylsulfinyl) (methylthio) methane (3.16 g, 0.0255 mol) was dissolved in 50 mL of dry THF under argon and then cooled [TO-78°C.] Butyllithium in hexane (16 mL 1.6M, 0.0256 mol) was added dropwise with stirring. The mixture was stirred for 15 min. Meanwhile a solution of 2,4, [5-TRIFLUOROBENZONITRILE] (2.0 g; 0.013 mol) in 50 mL of dry THF was cooled to-78°C under argon and the former solution was added through a cannula to the latter solution over a period of 3-5 min. After 30 min, the cooling bath was removed and when the reaction had reached room temperature it was poured into 200 mL of water. The THF was evaporated and the remaining aqueous layer was extracted three times with diethyl ether. The combined ether phase was washed with water, dried (Na2SO4) and evaporated. The crude product started to crystallise and could be used as such in the next step. Yield: 2.8 g (84%). 'H NMR (500 MHz, [CDCI3)] [5] 7.51-7. 44 (m, 2H, major diastereomer), 7.39 (dd, [1H,] minor diastereomer), 5.00 (s, 1H, minor diastereomer), 4.92 (s, 1H, major diastereomer), 2.59 (s, 3H, minor diastereomer), 2.56 (s, [1H,] major diastereomer), 2.46 (s, [1H,] minor diastereomer), 2.40 (s, [1H,] major diastereomer)

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - US2004/19033, 2004, A1 Location in patent: Page/Page column 49
[2]Current Patent Assignee: ASTRAZENECA PLC - WO2003/101956, 2003, A1 Location in patent: Page 137; 138

27
[ 98349-22-5 ]
[ 74-89-5 ]
4-Methylamino-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	In ethanol for 3h;	11.c.1 To a solution of 2,4,5 -trifluorobenzonitrile (0.575 g, 3.7 mmol) in ethanol (20 ml) was added methylamine (30% aq, 4.2 ml, 37 mmol) and the mixture stirred for 3 h. The reaction mixture was then partitioned between diethyl ether (100 ml) and water (100 ml), and the aqueous layer re-extracted with diethyl ether (100 ml). The combined ether extract was washed with brine (200 ml), dried (MgSO4) and evaporated to give 2,5-difluoro-4-methylaminobenzonitrile (0.549 g, 89%), mp 160-163 0C.1H nmr (500 MHz, CDCl3) δ 2.92, d (J = 5.0 Hz), 3H, NMe; 4.68, br, IH, NH; 6.36, dd (J = 7.3, 10.8 Hz), IH, H3; 7.10, dd (J = 6.0, 11.0 Hz), IH, H6. MS (ESI +ve) m/z 169 (MH+, 100%).

Reference： [1]Current Patent Assignee: PETER MACCALLUM CANCER CENTER - WO2008/74091, 2008, A1 Location in patent: Page/Page column 50

28
[ 624-31-7 ]
[ 98349-22-5 ]
[ 1224249-97-1 ]

Yield	Reaction Conditions	Operation in experiment
81%	With palladium diacetate; potassium carbonate; silver carbonate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl In water; ethyl acetate at 23℃; for 16h; Inert atmosphere;

Reference： [1]Rene, Olivier; Fagnou, Keith [Organic Letters, 2010, vol. 12, # 9, p. 2116 - 2119]

29
[ 932-01-4 ]
[ 98349-22-5 ]
[ 1224048-13-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 2365 - 2369

30
[ 122536-76-9 ]
[ 98349-22-5 ]
[ 1269407-54-6 ]

Yield	Reaction Conditions	Operation in experiment
74%	With potassium carbonate In N,N-dimethyl-formamide at 100℃;	98 To a solution of 1,1-dimethylethyl (35)-3-pyrrolidinylcarbamate (178 mg, 0.955 mmol) and 2,4,5-trifluorobenzonitrile (150 mg, 0.955 mmol) in DMF (2.5 mL) was added K2CO3 (132 mg, 0.955 mmol). The reaction vial was capped and heated to 100 0C overnight. Upon cooling, water (5 mL) and EtOAc (3 mL) were added. The layers were separated, and the aqueous layer was extracted with EtOAc (4 x 1 mL). The combined organic layers were washed with brine (3 x 1 mL) and then concentrated onto Isolute. Purification via flash column chromatography (0-80% EtOAc/hexanes) afforded the title compound (227 mg, 74%). LC-MS m/z 324 (M+H)+, 1.12 min (ret time).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2011/25799, 2011, A1 Location in patent: Page/Page column 84

31
[ 1334435-85-6 ]
[ 98349-22-5 ]
[ 1334438-37-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium <i>tert</i>-butylate In tetrahydrofuran; methanol at -30 - 0℃; for 31h;	540 To a solution of 1.10 g of 2,4,5-trifluorobenzonitrile and 500 mg of t-butyl 5-cyclopropyl-4-(2-hydroxyethyl)-3,4,6,7,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepine-8(2H)-carboxylate in 15 ml of THF was added portionwise 150 mg of potassium t-butoxide, followed by stirring at -30° C. for 2 hours. Further, to the reaction mixture was added 0.15 ml of MeOH and then 150 mg of potassium t-butoxide was added portionwise thereto, followed by elevating the temperature to -10° C. and stirring for 15 hours. Further, to the reaction mixture were added 0.15 ml of MeOH, and then 150 mg of potassium t-butoxide was added portionwise thereto, followed by elevating the temperature to 0° C. and stirring for additional 14 hours. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent: HEX-EtOAc)) to obtain 726 mg of t-butyl 4-[2-(4-cyano2-fluoro-5-methoxyphenyl)ethyl]-5-cyclopropyl-3,4,6,7,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepine-8(2H)-carboxylate as a colorless viscous substance.

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US2011/269744, 2011, A1 Location in patent: Page/Page column 23

32
[ 65735-71-9 ]
[ 98349-22-5 ]
[ 1355637-34-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With potassium carbonate; In dimethyl sulfoxide; at 20℃; for 18h;	Preparation 612,5-Difluoro-4-[4-chloro-3-(trifluoromethyl)phenylmethoxy1-benzonitrileTo a sol ution of 4-chloro-3-(thfluoronnethyl)-benzylalcohol (0.27 g, 1 .28 mmol) and 2,4,5-trifluorobenzonitrile (0.2 g, 1 .28 mmol) in DMSO (5 mL) was added potassium carbonate (0.33 g, 0.25 mmol). The resulting mixture was stirred at room temperature for 18 hours. The reaction mixture was partitioned between water (15 mL) and EtOAc (20 mL). The organic layer was separated, dried over magnesium sulphate, filtered and evaporated to yield the title compound (0.43 g, 97percent).1H NMR (CD3OD, 400 MHz): delta 5.28 (s, 2H), 7.30 - 7.38 (m, 1 H), 7.55 - 7.75 (m, 3H), 7.90 (s, 1 H).Molecular ion not observed

Reference： [1]Patent: WO2012/7868,2012,A2 .Location in patent: Page/Page column 96

33
[ 65735-71-9 ]
[ 98349-22-5 ]
[ 1355637-36-3 ]

Reference： [1]Patent: WO2012/7868,2012,A2

34
[ 98349-22-5 ]
[ 33577-16-1 ]
[ 433940-02-4 ]

Yield	Reaction Conditions	Operation in experiment
26%	Stage #1: methyl methylsulfinylmethyl sulfide With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran; hexanes at -78 - 20℃; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water for 5h;	20 Preparation 202,5-Difluoro-4-formylbenzonitrilen-Butyllithium solution (1 .6 M in hexanes, 8.75 mL, 14 mmol) was added dropwise to a solution of methyl methylthiomethyl sulfoxide (1 .58 g, 12.7 mmol) in THF (25 mL) at -78 °C. After 30 minutes at -78°C, 2,4,5-trifluorobenzonitrile (commercial, 1 g, 6.35 mmol) was added dropwise. The solution was then allowed to warm to room temperature, and stirred for 18 hours under a nitrogen atmosphere. The deep red reaction mixture was poured into water (75 mL), and extracted with EtOAc (2 x 75 mL). The combined organics were dried over magnesium sulphate and evaporated to yield a brown oil. The oil was redissolved in THF (1 5 mL) and concentrated sulphuric acid (4.1 mL, 77.2 mmol) and water (4 mL) were added . After stirring for 5 hours the reaction was quenched with saturated aqueous sodium bicarbonate (30 mL) and extracted with EtOAc (2 x 50 m L). The combined organic extracts were dried over magnesium sulphate, and evaporated to yield a brown oil, which was purified by silica gel chromatography eluting with 50 % heptane in DCM to afford the title compound as a yellow oil (280 mg, 26%).1H N MR (400 MHz, CDCI3): δ 7.53 (dd, 1 H), 7.70 (dd, 1 H), 10.35 (s, 1 H).LCMS Rt = 2.71 minutes MS m/z 262 [M+H]+

Reference： [1]Current Patent Assignee: PFIZER INC - WO2012/7868, 2012, A2 Location in patent: Page/Page column 82-83

35
[ 1355066-41-9 ]
[ 98349-22-5 ]
[ 1446444-64-9 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 5-chloro-6-(1-propan-2-yloxy)-3-pyridinol; 2,4,5-trifluorobenzonitrile With potassium carbonate In dimethyl sulfoxide at 20℃; for 2.5h; Stage #2: With dihydrogen peroxide In water; dimethyl sulfoxide at 0 - 20℃; for 18h; Inert atmosphere;	25 Preparation 25 4-((5-chloro-6-isopropoxypyhdin-3-yl)oxy)-2,5-difluorobenzamide A solution of 5-chloro-6-isopropoxypyhdin-3-ol (Preparation 30, 490 mg, 2.61 mmol), trifluorobenzonitrile (41 1 mg, 2.61 mmol), and K2CO3 (1085 mg, 7.86 mmol) in DMSO (10 mL) was stirred at room temperature for 2.5 hours. The solution was then cooled to 0 °C, further K2CO3 (1500 mg, 10.3 mmol) was added followed by H2O2 (30%, 5.0 mL, 44 mmol) and stirred for 18 hours at room temperature under nitrogen. The mixture was diluted with H2O ( 80 mL) and stirred for 2 hours, followed by extraction with EtOAc (3 x 30 mL). The combined organic layers were washed with H2O (10 mL), and then brine (30 mL), dried over MgSO4, filtered and the solvent removed in vacuo to give the title compound (960 mg, 107%) as a colourless solid. 1 H NMR (400 MHz, d6-DMSO): δ ppm 1 .30 (m, 6H), 5.25 (m, 1 H), 7.10 (m, 1 H), 7.65 (m, 3H), 7.90 (m, 1 H), 8.07 (m, 1 H). LCMS Rt = 3.27 minutes MS m/z 343 [MH]+

Reference： [1]Current Patent Assignee: PFIZER INC - WO2013/102826, 2013, A1 Location in patent: Page/Page column 82

36
[ 541-16-2 ]
[ 98349-22-5 ]
[ 1374358-05-0 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: t-butyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In N,N-dimethyl-formamide at 80℃; for 8h;	Step A: di-tert-butyl (4-cyano-2, 5-difluorophenyl)propanedioate Step A: di-tert-butyl (4-cyano-2, 5-difluorophenyl)propanedioate: A suspension of NaH (60% in mineral oil, 2.6 g, 64 mmol) in dry DMF (120 mL) was stirred and cooled to 0 °C, and di-tertbutyl malonate (9.0 g, 41 mmol) was added over 30 mm. The mixture was allowed to warm to room temperature before addition of 2, 4, 5-trifluorobenzonitrile (5.0 g, 32 mmol). After beingheated at 80 °C for 8 h with stirring, the reaction mixture was cooled to room temperature and poured into a mixture of ice-water (100 mL) and AcOEt (200 mL). Layers were separated, and the organic layer was washed successively with water, and brine, then dried over MgSO4 and concentrated. The residue was purified by flash chromatography (silica gel, EtOAc/hexanes, 2:8) to give the title compound. LCMS: [(M+1)-t-Bu] = 239.3.
10.0 g	Stage #1: t-butyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h; Stage #2: 2,4,5-trifluorobenzonitrile In N,N-dimethyl-formamide; mineral oil at 20 - 80℃; for 11h;	23.A Di-tert-butyl (4-cyano-2,5-difluorophenyl)propanedioate To a suspension of NaH (2.6 g, 64 mmol, and 60.0% dispersion in oil) in DMF (80 mL) was added a solution of di-tert-butyl malonate (3.57 g, 16.50 mmol) in DMF (20 mL) at 0 °C and this was stirred for 15 min. Subsequently, 2,4,5-trifluorobenzonitrile (3.0 g, 15.0 mmol) was added in one portion and the reaction mixture was stirred for 8 h at 80 °C and three hours at room temperature. Water (50 mL) was added and the aqueous layer was extracted with EtOAc (2 x 100 mL). The combined organic extracts were washed with water (50 mL) and brine (50 mL), dried over MgSO4 and filtered. After evaporation in vacuo, the residue was purified by flash chromatography (20% EtOAc in hexane) to give 10.0 g of di-tert-butyl (4-cyano-2,5-difluorophenyl)propanedioate as a colorless oil. 1H NMR (500 MHz, CDCl3) δ 7.51 (dd, J = 5.5, J = 5.4 Hz, 1H), 7.37 (dd, J = 5, J = 6 Hz, 1H), 4.84 (s, 1H), 1.50 (s, 18H). LC-MS (IE, m/z): 298.2 [(M+1)]+ - t-Bu].
	Stage #1: t-butyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,4,5-trifluorobenzonitrile In N,N-dimethyl-formamide; mineral oil at 0 - 60℃;	12 Di-tert-butyl 2-(4-cyano-2,5-difluorophenyl)malonate Under nitrogen atmosphere, to a solution of sodium hydride (60% dispersion in mineral oil) (5.09 g, 127.31 mmol) in anhydrous DMF (100 mL) at 0 oC was added Di-tert-butyl malonate (8.26 g, 31.19 mmol) dropwise over 15 min. After the reaction was stirred at 0 oC for 15 min, 2,4,5-Trifluorobenzonitrile (5.00 g, 31.83 mmol) was added to the reaction in one portion. The mixture was stirred at 0 oC for 15 min, followed by stirring at 60 oC overnight. After the reaction was completed by TLC analysis, the mixture was quenched with an aqueous saturated NH4Cl solution (800 mL) and extracted with EtOAc (200 mL x 3). The combined organic phase was washed with water (100 mL x 2), dried with anhydrous Na2SO4 (50 g), filtered and concentrated in vacuo.12.60 g of the crude title compound as yellow oil was obtained, which was used in the next step without further purification. LC-MS (ESI+): m/z 239 (M-(t-Bu)2)+.

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2014/99633, 2014, A2 Location in patent: Page/Page column 87
[2]Current Patent Assignee: MERCK & CO INC - EP2632465, 2015, B1 Location in patent: Paragraph 0159
[3]Current Patent Assignee: AKEBIA THERAPEUTICS, INC. - WO2021/188936, 2021, A1 Location in patent: Paragraph 0385-0386

37
[ 168644-93-7 ]
[ 98349-22-5 ]

Reference： [1]ChemSusChem,2015,vol. 8,p. 92 - 96
[2]Organic and Biomolecular Chemistry,2016,vol. 14,p. 3356 - 3359

38
[ 141-97-9 ]
[ 98349-22-5 ]
ethyl 1-(4-cyano-2,5-difluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	Stage #1: 2,4,5-trifluorobenzonitrile With sodium azide; sodium carbonate In water; acetonitrile at 25℃; for 0.5h; Stage #2: ethyl acetoacetate In water; acetonitrile	4.2. General procedure for the target compounds 3 General procedure: To a solution of polyfluoroarene 1 (1 mmol) in 5 mL CH3CN and 0.1 mL H2O, sodium azide (78 mg, 1.2 mmol), Na2CO3 (318 mg,3 mmol) were added successively. The mixture was stirred for 0.5 h at room temperature. Then, active methylene ketone/ester 2 (2 mmol) was added. The reaction mixture was stirred for 1-3 h until the reaction was completed (TLC). The reaction was quenched with H2O (20 mL). After filtering, the filtrate was extracted with CH2Cl2 (20 mL x 3) and washed successively with H2O and brine. The combined organic layers were dried over anhydrous MgSO4 and concentrated under vacuum. The crude product was purified by chromatography on silica gel (petroleum ether/EtOAc = 20:1) to afford the product 3.

Reference： [1]Wu, Jingjing; Fu, Dan; Cao, Song [Journal of Fluorine Chemistry, 2014, vol. 168, p. 230 - 235]

39
[ 98349-22-5 ]
[ 108-95-2 ]
2,5-difluoro-4-phenoxybenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	3.1 Synthesis of 2,5-difluoro-4-phenoxybenzonitrile Into a 50-m L round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2,4,5-trifluorobenzonitrile (500 mg, 3.18 mmol, 1 .00 equiv) in N,N- dimethylformamide (10 mL), phenol (300 mg, 3.19 mmol, 1 .00 equiv), K2C03 (900 mg, 6.46 mmol, 2.00 equiv). The resulting solution was stirred overnight at room temperature abd then the reaction was quenched by the addition of 200 m L of water. The resulting solution was extracted with ethyl acetate (3x100 m L) and the combined organic layers were washed with brine (4x300 mL), dried over sodium sulfate and concentrated under vacuum . The residue was purified via column chromatography with an eluent of ethyl acetate/petroleum ether (1 :20). This resulted in 400 mg (54%) of 2,5-difluoro-4- phenoxybenzonitrile as a white solid.

Reference： [1]Current Patent Assignee: DEGIACOMO; DEGIACOMO MARK G - WO2015/130957, 2015, A1 Location in patent: Page/Page column 51

40
[ 349-58-6 ]
[ 98349-22-5 ]
4-[3,5-bis(trifluoromethyl)phenoxy]-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;	<strong>[349-58-6]3,5-Bis(trifluoromethyl)phenol</strong> (300 mg, 1 .30 mmol, 1 .00 equiv), N,N-2,4,5-trifluorobenzonitrile (205 mg, 1 .30 mmol, 1 .00 equiv), and potassium carbonate (359 mg, 2.60 mmol, 1 .99 equiv) were dissolved in 10 m L of DMF under an inert atmosphere of nitrogen. The mixture was then stirred overnight at room temperature and quenched by the addition of 100 m L of water. The resulting solution was extracted with 3x50 mL of ethyl acetate and the combined organic layers were concentrated in vacuo. The residue was purified by silica gel column chromatography with an eluent of ethyl acetate/petroleum ether (1 :20). This resulted in 450 mg (94percent) of 4-[3,5-bis(trifluoromethyl)phenoxy]-2,5-difluorobenzonitrile as a white solid.

Reference： [1]Patent: WO2015/130957,2015,A1 .Location in patent: Page/Page column 53-54

41
[ 98349-22-5 ]
2-iodo-N-methyl-N-(2-methylallyl)aniline [ No CAS ]
3-((1,3-dimethyl-2-oxoindolin-3-yl)methyl)-2,4,5-trifluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; silver carbonate In water; ethyl acetate at 75℃; for 24h; Inert atmosphere;

Reference： [1]Wu, Xin-Xing; Chen, Wen-Long; Shen, Yi; Chen, Si; Xu, Peng-Fei; Liang, Yong-Min [Organic Letters, 2016, vol. 18, # 8, p. 1784 - 1787]

42
4-cyclopropyl-5-(trifluoromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
[ 98349-22-5 ]
4-[4-cyclopropyl-5-oxo-3-(trifluoromethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39%	Stage #1: 4-cyclopropyl-5-(trifluoromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one With sodium hydride In N,N-dimethyl acetamide; mineral oil at 0℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In N,N-dimethyl acetamide; mineral oil at 20℃; for 72h;	4 - [4-cyclopropyl-5-oxo-3 - (trifluoromethyl) - 4,5-dihydro -1H-1, 2, 4-triazol-1-yl] - 2,5-difluoro-benzonitrile(XXIV-1) In 0 °C lower, to 202 mg (5.0mmol) of sodium hydride (in mineral oil in order to 60%) in 30 ml of N, N-dimethyl formamide is added to a solution of 974 mg (5.0mmol) of 4-cyclopropyl-5 - (trifluoromethyl) - 2,4-dihydro -3H-1, 2, 4-triazol-3-one (under EP657437A1; DE4339412A1 preparation). In 0 °C lower stirring 30 minutes later, by adding 660 mg (4.2mmol) of 2, 4, 5- three fluorine animal pen nitrile. The reaction mixture is stirred at room temperature for 3 days, then in the dumping of water, neutralized, then with tertiary butyl methyl ether extraction. In the combined organic phase is water and washing with saturated sodium chloride aqueous solution, the magnesium sulfate drying, filtering, and then the solvent is removed under reduced pressure. Through column chromatography by means of MPLC with cyclohexane/ethyl acetate as an eluent purified on silica gel, to obtain 539 mg (the purity is 100%, of the theoretical value 39%) of the subject compound, a yellow solid.
30%	Stage #1: 4-cyclopropyl-5-(trifluoromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 2,4,5-trifluorobenzonitrile In N,N-dimethyl-formamide; mineral oil at 20℃; for 72h; Further stages;	4-[4-Cyclopropyl-5-oxo-3-(trifluoromethyl)-4,5-dihydro- iH- 1 ,2,4-triazol-i -yl]-2,5-difluorobenzoni- trile (XXIV-i) 11761] To a solution of 202 mg (5.0 mmol) of sodium hydride (60% in mineral oil) in 30 ml of N,N-dimethylformamide are added, at 00 C., 974mg (5.0 mmol) of 4-cyclo- propyl-5-(trifluoromethyl)-2,4-dihydro-3H-i ,2,4-triazol-3- one (prepared according to EP 657437 Al; DE 4339412 Al). Afier stirring at 00 C. for 30 minutes, 660 mg (4.2 mmol) of 2,4,5-trifluorobenzonitrile are added. The reaction mixture is stirred at room temperature for 3 d, then poured into water, neutralized and extracted with tert-butyl methyl ethet The combined organic phases are washed successively with water and saturated aqueous sodium chloride solution, dried over magnesium sulphate, filtered and freed of the solvent under reduced pressure. Purification by column chromatography on silica gel by means of MPLC with cyclohexane/ethyl acetate as eluent gives 539mg (100% pure, 39% of theory) of the title compound as a yellow solid.11762] log P[a]: 2.91; log P[a]: 2.90; 1H NMR (D6- DMSO): 8.29 (dd, 1H), 7.84 (dd, 1H), 3.10-3.04 (m, 1H), 1.23-1.01 (m, 4H)

Reference： [1]Current Patent Assignee: BAYER AG - CN105473558, 2016, A Location in patent: Paragraph 1998; 1999; 2000; 2001; 2002; 2003
[2]Current Patent Assignee: BAYER AG - US2016/145235, 2016, A1 Location in patent: Paragraph 1760; 1761; 1762

43
N-ethyl-5-fluoro-2-hydroxybenzenesulfonamide [ No CAS ]
[ 98349-22-5 ]
6-ethyl-3,8-difluoro-6H-dibenzo[b,f][1,4,5]oxathiazepine-9-carbonitrile 5,5-dioxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere; regiospecific reaction;	1 4.5. General procedure for preparation of compounds 8a-n General procedure: The respective 2-hydroxybenzenesulfonamide 5 (2 mmol) and 1,2-dihaloarene (1-halo-2-nitroarene) partner 9 (2 mmol) were combined in anhydrous DMF (7 mL) with freshly calcinated K2CO3 (829 mg, 6 mmol) and the mixture was kept, with stirring, at the temperature and for the time period indicated in Table 2. DMF was removed in vacuo and the residue was treated with water (10 mL), which caused a viscous oil to separate. It was extracted with CH2Cl2 (5 mL), the organic layer was separated, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel using an appropriate gradient of CH2Cl2 in hexanes as eluent.

Reference： [1]Sapegin, Alexander; Panova, Valeria; Reutskaya, Elena; Smirnov, Alexey V.; Krasavin, Mikhail [Tetrahedron, 2016, vol. 72, # 47, p. 7570 - 7578]

44
[ 98349-22-5 ]
2-hydroxy-N-methoxybenzamide [ No CAS ]
8-fluoro-10-methoxy-11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepine-7-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 3h;	General procedure for preparation of compounds 7a-j General procedure: The respective N-alkoxysalicylamide 10 (2 mmol) and 1,2-dihaloarene (1-halo-2-nitroarene) partner 2 (2 mmol) were combined in anhydrous DMF (7 mL) with freshly calcinated K2CO3 (829 mg, 6 mmol) and the mixture was kept, with stirring, at the temperature and for the time period indicated in Table 2. DMF was removed in vacuo and the residue was treated with water (10 mL), which caused a viscous oil to separate. It was extracted with CH2Cl2 (5 mL), the organic layer was separated, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel using an appropriate gradient of CH2Cl2 in hexanes as eluent.

Reference： [1]Sapegin, Alexander; Reutskaya, Elena; Smirnov, Alexey; Korsakov, Mikhail; Krasavin, Mikhail [Tetrahedron Letters, 2016, vol. 57, # 52, p. 5877 - 5880]

45
[ 98349-22-5 ]
[ 123855-51-6 ]
tert-butyl 4-(4-cyano-2,5-difluorophenoxymethyl)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75.8%	With potassium <i>tert</i>-butylate In tetrahydrofuran; acetonitrile at -40 - -30℃; for 1h;	132 tert-butyl 4-(4-cyano-2,5-difluorophenoxymethyl)piperidine-1-carboxylate [003321 2,4,5-trifluorobenzonitrile (218.9 mg, 1.39 mmol) and tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate (200 mg, 0.93 mmol) were dissolved in anhydrous THF (4 ml) and potassium 2-methylpropan-2-olate (125.09 mg, 1.11 mmol) was addei Reaction was cooled to-30--40°C in a dry iceIMeCN bath and the internal reaction temperature monitored. Once cooled, KOtBu (250.18 mg, 2.23 rnmol) was added portion wise, maintaining reaction temperature between-30--40°C. Reaction was stirred at-30 to-40°C for lh. On completion, the reaction was diluted with 2Oml water and extracted with EtOAc (3 x I 5ml). The combined organics were washed with brine and dried over Na2SO4. The product was purified by column chromatography to yield 496 mg (75.8%) of the title compound. The structure confirmed by HSQC NMR. METCR1 673 Generic 2 minutes MZ (ES+) 365, Retention time 1.15 mm.1H NMR (250 MHz, DMSO-d6) 7.94 (dd, J = 10.8, 6.3 Hz, 1H), 7.48 (dd, J = 11.3, 7.0 Hz, 1H), 4.05 (d, J = 6.4 Hz, 2H), 4.03 -3.89 (m, 2H), 2.86-2.64 (m, 2H), 2.11 - 1.87 (m, lH),l.81-1.65 (m, 2H), 1.40 (s, 9H), 1.19 (ddd, J = 16.2, 9.9,4.1 Hz, 2H).

Reference： [1]Current Patent Assignee: MERCK KGAA - WO2017/45751, 2017, A1 Location in patent: Paragraph 00332

46
[ 98349-22-5 ]
[ 105-56-6 ]
C₁₂H₈F₂N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15.03 g	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h;	7.1 Synthesis of Compound G2 G1 (11.00 g, 70.02 mmol), E2 (7.92 g, 70.02 mmol) and Potassium carbonate (11.61 g, 84.03 mmol) were added to 150 ml of DMF and the mixture was stirred at room temperature for 4 hours. After completion of the reaction, water and acetic acid were added, stirred for 30 minutes, extracted with chloroform, and concentrated to obtain G2 (15.03 g, 85.79 mmol)

Reference： [1]Current Patent Assignee: LG DISPLAY CO.,LTD. - KR2017/79350, 2017, A Location in patent: Paragraph 0364-0367

47
[ 118801-67-5 ]
[ 98349-22-5 ]
2,5-difluoro-4-(3-oxo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56%	With potassium carbonate In acetonitrile Reflux;	2,5-difluoro-4-(3-oxo-5,6,7,8-tetrahydro[1 ,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)benzonitrile To a solution of 2,4,5-trifluorobenzonitrile (1 .08 g, 6.9 mmol) and potassium carbonate (1 .9 g, 13.8 mmol) in acetonitrile (25 ml) was added 5,6,7,8-tetrahydro[1 ,2,4]triazolo[4,3-a]pyridin- 3(2H)-one [CAS 1 18801 -67-5] (1 .05 g, 7.6 mmol), and the mixture was heated under reflux overnight. The mixture was then cooled to room temperature, poured into water (150 ml), and extracted with dichloromethane (3 x 300 ml). The organic phases were dried over sodium sulfate, and concentrated under reduced pressure, and the residue was purified by flash chromatography to yleld the title compound as an off-white solid (1 .06 g, 56%). LC-MS (method A): R, = 0.91 min; MS (ESIpos): m/z = 277 [M+H]+1H-NMR (400 MHz, CHLOROFORM-d) δ [ppm]: 1 .194 (16.00), 1 .896 (1 .10), 1 .898 (1 .22), 1 .905 (1 .49), 1 .914 (3.31 ), 1 .920 (3.80), 1 .926 (4.48), 1.936 (4.46), 1 .941 (5.07), 1.944 (3.41 ), 1 .953 (2.17), 1 .957 (2.32), 1 .978 (2.44), 1 .982 (2.02), 1.992 (4.35), 1 .997 (4.41 ), 2.008 (4.81 ), 2.013 (3.80), 2.019 (2.76), 2.022 (3.01 ), 2.028 (1 .50), 2.035 (1.36), 2.050 (0.42), 2.776 (7.63), 2.793 (13.88), 2.808 (8.54), 3.218 (5.28), 3.691 (9.78), 3.707 (15.57), 3.722 (6.87), 7.448 (5.53), 7.462 (5.56), 7.472 (5.65), 7.486 (5.47), 7.644 (5.43), 7.658 (5.52), 7.667 (5.42), 7.682 (5.28).

Reference： [1]Current Patent Assignee: MASS GENERAL BRIGHAM INC; BAYER AG; HARVARD UNIVERSITY; BROAD INSTITUTE - WO2018/77944, 2018, A2 Location in patent: Page/Page column 251; 252

48
[ 98349-22-5 ]
[ 149771-44-8 ]
tert-butyl-3-(2-cyano-4,5-difluorophenyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
18%	With potassium carbonate; In dimethyl sulfoxide; at 100℃; for 16h;	The mixture of 2,4,5-trifluorobenzonitrile (300 mg, 1.91 mmol), tert-butyl-3,8- diazabicyclo[3.2.1]octane-8-carboxylate (486 mg, 2.92 mmol) and K2C03 (396 mg, 2.86 mmol) in DMSO (20 mL) was stirred at 100 C for 16 h. The mixture was purified by chromatography (silica, PE/EtOAc = 3/1) to afford tert-butyl-3 -(2-cyano-4, 5 -difluorophenyl)-3 , 8- diazabicyclo[3.2.1]octane-8-carboxylate (120 mg, 0.343 mmol, 18 %) as yellow solid. ESI-MS (Erb, m/z): 350.2 [M+H]t

Reference： [1]Patent: WO2018/89433,2018,A1 .Location in patent: Paragraph 00695

49
[ 98349-22-5 ]
[ 201162-53-0 ]
tert-butyl 8-(2-cyano-4,5-difluorophenyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	With potassium carbonate; In dimethyl sulfoxide; at 100℃; for 16h;	A mixture of 2,4,5-trifluorobenzonitrile (314 mg, 2 mmol), tert-butyl-3,8- diazabicyclo[3.2.1]octane-3-carboxylate (212 mg, 1 mmol) and K2C03 (276 mg, 2 mmol) in DMSO (5 mL) was stirred at 100 C for 16 h. The mixture was purified by chromatography (silica,PE/EtOAc = 3/1) to afford tert-butyl-8-(2-cyano-4, 5 -difluorophenyl)-3 , 8-diazabicyclo[3.2.1]octane-3-carboxylate (91 mg, 0.26 mmol, 26%) as a yellow oil. ESI-MS (Erb, m/z): 350.2 [M+H]t

Reference： [1]Patent: WO2018/89433,2018,A1 .Location in patent: Paragraph 00704

50
[ 98349-22-5 ]
[ 169447-70-5 ]
(S)-tert-butyl 4-(4-cyano-2,5-difluorophenyl)-2-methylpiperazine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With potassium carbonate In acetonitrile at 80℃; for 16h;	88.1 Step 1: (S)-tert-butyl 4-(4-cyano-2,5-difluorophenyl)-2-methylpiperazine- 1-carboxylate The mixture of 2,4,5-trifluorobenzonitrile (1.0 g, 6.4 mmol), (S)-tert-butyl 2- methylpiperazine-1-carboxylate (1.53 g, 7.6 mmol) and K2C03 (2.64 g, 19.1 mmol) in MeCN (20 mL) were stirred at 80 °C for 16 h. The mixture was then filtered, washed with MeCN (5 mL x 2), concentrated, and purified by chromatography (PE:EtOAc = 2:3) to afford (S)-tert-butyl 4-(2- cyano-4,5-difluorophenyl)-2-methylpiperazine-1-carboxylate (1.8 g, 84%) as a white solid. MS (EI+, m/z): 338.2 [M+H]t

Reference： [1]Current Patent Assignee: NAVITOR PHARM - WO2018/89433, 2018, A1 Location in patent: Paragraph 00723

51
4-methyl-5-(propan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
[ 98349-22-5 ]
2,5-difluoro-4-[4-methyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With potassium carbonate In acetonitrile Reflux;	Intermediate 80 2,5-difluoro-4-[4-methyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]benzonitrile 4-methyl-5-(propan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2.91 g, 20.6 mmol) and potassium carbonate (5.70 g, 41 .2 mmol) were suspended in acetonitrile (50 ml). 2,4,5-trifluorobenzonitrile (2.4 ml, 21 mmol) was added and the mixture was refluxed overnight. The mixture was cooled and the precipitate was filtered off. The solids were was washed with acetonitrile and the combined washes were concentrated. The resulting solid was washed, triturated with hexanes, and filtered. The solids were washed with hexanes and dried to yield the desired product (5.3g, 91 % yield).

Reference： [1]Current Patent Assignee: BROAD INSTITUTE; BAYER AG; MASS GENERAL BRIGHAM INC; HARVARD UNIVERSITY - WO2018/77923, 2018, A1 Location in patent: Page/Page column 290

52
[ 22419-35-8 ]
[ 98349-22-5 ]
4-((4,4-difluorocyclohexyl)oxy)-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%		Potassium 2-methylpropan-2-olate (1.704 g, 15.19 mmol) was suspended in THF (40mL) and the mixture was cooled to 0°C. 4,4-Difluorocyclohexanol (2.23 g, 16.38mmol) was added and the solution was stirred at 0°C for 30min. The temperature waslowered to -78°C followed by dropwise addition of 2,4,5-trifluorobenzonitrile (2.339 g,14.89 mmol) in THF(25 mL) at -78 oc under nitrogen. The solution was stirred at -78oc for 2h and warmed to room temperature over 1. 5h. Water (200 mL) was added to the reaction mixture, extracted with EtOAc (100 mL *3), the combined organic phases werewashed with water and brine, dried over sodium sulfate and the solvent was removed invacuum. The residue was purified by flash chromatography on silica (heptane/Et0Ac:95/5percent to 52/48percent). 4-((4,4-Difluorocyclohexyl)oxy)-2,5-difluorobenzonitrile was obtained as viscous oil (3.08 g; yield 76percent).

Reference： [1]Patent: WO2018/175449,2018,A1 .Location in patent: Page/Page column 79

53
[ 22419-35-8 ]
[ 98349-22-5 ]
4-((4,4-difluorocyclohexyl)oxy)-5-fluoro-2-methoxybenzonitrile [ No CAS ]

Reference： [1]Patent: WO2018/175449,2018,A1

54
trans (e,e)-4-trifluoromethylcyclohexanol [ No CAS ]
[ 98349-22-5 ]
2,5-difluoro-4-((trans-4-(trifluoromethyl)cyclohexyl)oxy)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66.1%	Stage #1: trans (e,e)-4-trifluoromethylcyclohexanol With potassium <i>tert</i>-butylate In tetrahydrofuran at 0℃; for 1h; Stage #2: 2,4,5-trifluorobenzonitrile In tetrahydrofuran at -70 - 20℃; for 16.6667h;	41 (2S)-N-[[5-Fluoro-2-methoxy-4-[trans 4-(trifluoromethyl)cyclohexoxy]phenyl]methyl]azetidine-2-carboxamide and its 2,2,2-trifluoroacetic acid addition salt To a solution of potassium 2-methylpropan-2-olate (0.280 g, 2.498 mmol) in THF (4 mL) was added dropwise a solution oftrans-4-(trifluoromethyl)cyclohexanol (0.4 g,2.379 mmol) in THF (2 mL) at 0°C, then it was stirred for 1 hour, the resulting abovesolution was added dropwise to a solution of2,4,5-trifluorobenzonitrile (0.448 g, 2.85mmol) in THF (4 mL) at -70°C over 40 minutes. Then the reaction mixture was stirredat -70°C for 3 hand allowed to warm to 20°C over 1.5 hand stirred at 20°C for 16 h. It was quenched with water, extracted with EtOAc three times, the extracts were washedwith brine, dried over Na2S04, filtered, concentrated to give the crude product, whichwas recrystallized from PE/EtOAc (5: 1) to give 2,5-difluoro-4-((trans-4-(trifluoromethyl)cyclohexyl)oxy)benzonitrile (0.480 g, 1.573 mmol, 66.1 %yield) aslight yellow solid.

Reference： [1]Current Patent Assignee: ABBVIE INC - WO2018/175449, 2018, A1 Location in patent: Page/Page column 92

55
[ 657-36-3 ]
[ 98349-22-5 ]
2,5-difluoro-4-[4-(trifluoromethyl)piperidin-1-yl]benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
2.66 g	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 0.25h;	To 2,4,5-trifluorobenzonitrile(1.57 g) of N,N-dimethylformamide (25 ml)To the solution were added <strong>[657-36-3]4-trifluoromethylpiperidine</strong> (1.68 g) and potassium carbonate (1.65 g).After the reaction solution was stirred at room temperature for 15 minutes,Water (50 ml) and ethyl acetate (50 ml) were added, and the organic layer was separated.Further, the organic layer was washed with water.After the organic layer was dried over MgSO 4 , the organic solvent was evaporated under reduced pressure.The residue is refined by a rubber tube column chromatography method.Obtained 2.66 g (m.p. 57.5-59.5 ° C)2,5-Difluoro-4-(4-(trifluoromethyl)piperidin-1-yl)benzonitrile

Reference： [1]Patent: TW2018/41890,2018,A .Location in patent: Page/Page column 60

56
4-ethyl-3-(tetrahydropyran-2-yloxymethyl)-1H-1,2,4-triazol-5-one [ No CAS ]
[ 98349-22-5 ]
4-[4-ethyl-5-oxo-3-(tetrahydropyran-2-yloxymethyl)-1,2,4-triazol-1-yl]-2,5-difluorobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With potassium phosphate In acetonitrile at 70 - 73℃; for 20h;	3 4-[4-Ethyl-5-oxo-3-(tetrahydropyran-2-yloxymethyl)-1,2,4-triazol-1 -yl]-2,5-difluoro- benzonitrile (A5) Intermediate (A4) (250 g, 1.10 mol) and 2,4,5-trifluorobenzonitrile (xxx5) (190 g, 1.21 mol) were stirred in acetonitrile (2500 ml.) and potassium phosphate (467 g, 2.20 mol) was added. The mixture was stirred at 70-73 °C for 20 h, then allowed to cool to room temperature. (0751) Water (1200 ml.) was added, and the mixture was stirred for 15 min. The organic phase was separated, washed with 10% aqueous sodium chloride (1200 ml.) and evaporated under reduced pressure at 40°C bath temperature to receive 414 g of a brown viscous oil. (0752) The residue was dissolved in anhydrous ethanol (915 ml.) at 40°C, then cooled to 25 °C to initate crystallization. Water (1250 ml.) was added and the suspension was stirred at 22°C. After stirring for 16 h, the solids were isolated, washed two times with ethanol/water (3:4 v/v, 245 ml.) and dried at 40°C in vacuo to give (A5) (367 g, 1 .01 mol, 91 % yield) as off-white solid. (0753) 1H NMR (400 MHz, DMSO-d6) d ppm 1.27 (t, J= 7.09 Hz, 3 H) 1 .51 (br d, J=7.46 Hz, 4 H) 1 .69 (br d, J=9.05 Hz, 2 H) 3.48 - 3.57 (m, 1 H) 3.72 - 3.81 (m, 3 H) 4.50 (d, J=12.84 Hz, 1 H) 4.66 (d, J=12.96 Hz, 1 H) 4.78 (br s, 1 H) 7.88 (dd, J=9.29, 5.75 Hz, 1 H) 8.22 (dd, J=9.66, 5.38 Hz, 1 H) (0754) LCMS (method 3): Rt = 1 .83 min; MS (ESIpos): m/z = 365 (M+H)+

Reference： [1]Current Patent Assignee: BAYER AG - WO2019/197239, 2019, A1 Location in patent: Page/Page column 91

57
[ 626-58-4 ]
[ 98349-22-5 ]
2,5-difluoro-4-(4-methylpiperidin-1-yl)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
2.93 g	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1.5h;	1 Example 1. Synthesis of 2,5-difluoro-4- (4-methylpiperidin-1-yl) benzonitrile (Compound number: B-1) 4-Methylpiperidine (1.43 g) and potassium carbonate (2.34 g) were added to a solution of 2,4,5-trifluorobenzonitrile (2.07 g) in N, N-dimethylformamide (15 ml). The reaction solution was stirred at room temperature for 1.5 hours, water (45 ml) and ethyl acetate (45 ml) were added, the organic layer was separated, and the organic layer was washed with water. After drying the organic layer with MgSO 4, the organic solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane: EtOAc = 4: 1 / Rf = 0.50) to give 2,5-difluoro-4- (4-methylpiperidin-1-yl) benzonitrile at 2.93 g (oil). Got with

Reference： [1]Current Patent Assignee: AGRO-KANESHO CO LTD - JP2020/59686, 2020, A Location in patent: Paragraph 0113

58
[ 128593-93-1 ]
[ 98349-22-5 ]

Yield	Reaction Conditions	Operation in experiment
92%	With potassium fluoride; 18-crown-6 ether In neat (no solvent) at 120 - 130℃;	2 Preparation of 2,4,5-trifluorobenzonitrile Add 380.0g of 2,4-dichloro-5-fluorobenzonitrile, 95.0g of 18-crown-6 and 290.5g of anhydrous potassium fluoride to a 1L reaction flask, and heat to 120-130C to react for 5-10 hours. After the reaction was completed, the temperature was lowered, filtered, and the filter cake was beaten with xylene, the organic phases were combined, and xylene 3 was recovered by short distillation. The vacuum degree was -0.095Mpa, and the fraction with the top temperature of 80-95 Cwas collected. Obtained 289.0g product, HPLC purity 99.2%, yield 92.0% The kettle residue is 206g.

Reference： [1]Current Patent Assignee: ZHEJIANG HUAJING FLUORINE CHEMISTRY TECH; SHANGHAI CHEMSPEC COPRORATION - CN112939782, 2021, A Location in patent: Paragraph 0102-0109

59
[ 108-86-1 ]
[ 98349-22-5 ]
3',5',6'-trifluoro-[1,1':4',1"-terphenyl]-2'-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84.5%	With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); 2-Ethylhexanoic acid; potassium carbonate; tricyclohexylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 100℃;	2-1 (2-1) Synthesis of Intermediate 3 Under a nitrogen stream, 3.0 g (19.1 mmol) of 2,4,5-trifluorobenzonitrile, 8.99 g (57.3 mmol) of bromobenzene, 7.92 g (57.3 mmol) of potassium carbonate, 2-ethylhexanoic acid. To a xylene solution (10 mL) of 0.28 g (1.91 mmol) and 0.48 g (1.72 mmol) of tricyclohexylphosphine, 0.40 g (0.57 mmol) of dichlorobis (triphenylphosphine) palladium (II) was added, and the temperature was 100 ° C. Stirred all night.After returning the reaction solution to room temperature, water was added to quench the reaction solution, and the mixture was extracted with chloroform.The solvent was distilled off by an evaporator, and the residue was purified by silica gel column chromatography (hexane: chloroform) to obtain 4.99 g (16.13 mmol, yield 84.5%) of the white solid intermediate 3.
74.6%	With 2-Ethylhexanoic acid; palladium diacetate; potassium carbonate; tricyclohexylphosphine In 5,5-dimethyl-1,3-cyclohexadiene; toluene at 140℃; for 15h; Inert atmosphere;	11 [Synthesis of 3',5',6'-trifluoro-[1,1':4',1"-terphenyl]-2'-carbonitrile (2PBN-D)] A 200 mL round-bottom flask was charged with 2,4,5-trifluorobenzonitrile (3.00 g, 19.1 mmol), bromobenzene (6.00 g, 38.2 mmol), 2-ethylhexanoic acid (280 mg, 1.91 mmol), potassium carbonate (7.91 g, 57.3 mmol) and 45 ml of xylene. The flask was then degassed and flushed with argon. Subsequently, tricyclohexylphosphine (5.10 ml of a 20% toluene solution, 2.87 mmol) and palladium acetate (214 mg, 0.96 mmol) were added to the flask, and the resulting mixture was stirred at 140° C. for 15 hours. The reaction mixture was then returned to room temperature, ethyl acetate was added, and the insoluble matter was removed by filtration using celite. The filtrate was then washed with water. Subsequently, the filtrate was dried over magnesium sulfate and then concentrated using a rotary evaporator. Next, 150 ml of chloroform was added to the concentrate, and the mixture was heated to dissolve the concentrate. Subsequently, 300 ml of n-hexane was added and the mixture was cooled. The precipitated white solid was collected by filtration to obtain 4.40 g of the target product (2PBN-D) (yield: 74.6%). 1H-NMR (400 MHz, CDCl3, δ): 7.54 to 7.47 (m, 10H)

Reference： [1]Current Patent Assignee: KYULUX, INC. - WO2021/251461, 2021, A1 Location in patent: Paragraph 0082; 0083
[2]Current Patent Assignee: NIPPON SODA COMPANY LIMITED; KYUSHU UNIVERSITY - US2021/332032, 2021, A1 Location in patent: Paragraph 0228-0231

60
[ 98349-22-5 ]
[ 124-40-3 ]
C₉H₁₀F₃N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With nickel trifluoromethanesulfonate; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine In 2,2,2-trifluoroethanol at 120℃; for 8h;

Reference： [1]Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. [Science, 2022, vol. 376, # 6600, p. 1433 - 1441]

61
[ 104-94-9 ]
[ 98349-22-5 ]
C₁₄H₁₂F₃NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With nickel trifluoromethanesulfonate; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine In 2,2,2-trifluoroethanol at 100℃; for 16h;

Reference： [1]Chandrashekhar, Vishwas G.; Baumann, Wolfgang; Beller, Matthias; Jagadeesh, Rajenahally V. [Science, 2022, vol. 376, # 6600, p. 1433 - 1441]

Same Skeleton Products

Related Products

Historical Records

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 98349-22-5 ] {[proInfo.proName]}

Quality Control of [ 98349-22-5 ]

Related Doc. of [ 98349-22-5 ]

Product Details of [ 98349-22-5 ]

Safety of [ 98349-22-5 ]

Application In Synthesis of [ 98349-22-5 ]

[ 98349-22-5 ] Synthesis Path-Upstream 1~3

[ 98349-22-5 ] Synthesis Path-Downstream 1~61

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry