Chemistry Heterocyclic Building Blocks Acridinium Series

Acridinium Series

Acridine exhibits antineoplastic, antimicrobial, and imaging properties. Its ability to intercalate with DNA and RNA through hydrogen bonding and stacking between base pairs leads to the formation of DNA crosslinks and strand breaks.Acridine and its derivatives are highly effective at inhibiting the activity of the topoisomerase II enzyme, thereby preventing the synthesis of both DNA and RNA. This inhibition predominantly occurs during the S phase of the cell cycle, ultimately resulting in cell death.Acridines are a class of polycyclic heteroarenes. It is derived from anthracene by the substitution of a nitrogen atom for one of the central CH groups. Acridine is a heterotricyclic parent compound and is classified as a polycyclic heteroarene. Additionally, it is known to act as a genotoxin.Acridines are planar molecules that are structurally similar to anthracene, except that one of the central CH groups is replaced by nitrogen. They are classified as substituted derivatives of the parent ring.Acridine, akin to pyridine and quinoline, displays mild basicity and forms needle-like crystals as an almost colorless solid. Although acridine dyes enjoyed popularity in the past, they now have limited commercial applications and are mostly restricted to niche usages such as with acridine orange.
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cLogP+−

H-Acceptors+−

H-Donors+−

Polar Surface Area+−

Druglikeness+−

NNCH/NNH+−

sp3-Atoms+−

Non-Aromatic Rings+−

Aromatic Rings+−

Rotatable Bonds+−

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