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Chemical Structure| 1374744-69-0 Chemical Structure| 1374744-69-0

Structure of Fedratinib HCl hydrate
CAS No.: 1374744-69-0

Chemical Structure| 1374744-69-0

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Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) emerges as a potent, selective, ATP-competitive, orally active JAK2 inhibitor, displaying IC50 values of 3 nM for both JAK2 and JAK2V617F kinase. Furthermore, Fedratinib hydrochloride hydrate demonstrates 35- and 334-fold selectivity over JAK1 and JAK3, respectively. It induces apoptosis in cancer cells and holds potential for research in myeloproliferative disorders.

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Product Details of Fedratinib HCl hydrate

CAS No. :1374744-69-0
Formula : C27H40Cl2N6O4S
M.W : 615.62
SMILES Code : O=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCN4CCCC4)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O.[H]Cl.[H]Cl.[H]O[H]
MDL No. :MFCD28137677
InChI Key :QAFZLTVOFJHYDF-UHFFFAOYSA-N
Pubchem ID :67517580

Safety of Fedratinib HCl hydrate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of Fedratinib HCl hydrate

epigenetics
RTK
JAK-STAT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.12mL

1.62mL

0.81mL

16.24mL

3.25mL

1.62mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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