Calcitonin gene-related peptide receptors (CGRP receptors) consist primarily of a complex of CLR (calcitonin receptor-like receptor) and RAMP1 (receptor activity-modifying protein 1). These receptors are widely distributed in the central and peripheral nervous systems, cardiovascular system, and immune system, primarily regulating processes such as vasodilation, inflammation response, pain transmission, and cardioprotection. CGRP receptors participate in intracellular signaling through the cAMP pathway. Gene expression exhibits tissue specificity, and alterations in the expression levels and functions of CLR and RAMP1 are closely associated with the occurrence and development of migraines, cardiovascular diseases, and other inflammatory conditions.