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Chemical Structure| 1123757-49-2 Chemical Structure| 1123757-49-2

Structure of CGRP antagonist 1
CAS No.: 1123757-49-2

Chemical Structure| 1123757-49-2

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CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.

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Product Details of CGRP antagonist 1

CAS No. :1123757-49-2
Formula : C29H26N4O4
M.W : 494.54
SMILES Code : O=C(NC1=CC2=C(C[C@@]3(C4=CC=CN=C4NC3=O)C2)C=C1)CN5C(C6(CCOCC6)C7=C5C=CC=C7)=O
MDL No. :N/A

Safety of CGRP antagonist 1

Related Pathways of CGRP antagonist 1

GPCR

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01064687 Diabetes Mellitus, Type 2 Phase 3 Completed - -
NCT01064687 - Completed - -
NCT02803554 Aging Not Applicable Completed - -
NCT03647657 Thyroid Cancer, Medullary Early Phase 1 Not yet recruiting October 2020 -
NCT01813591 Chronic Migraine Phase 2 Completed - United States, Missouri ... More >> Clinvest/A Division of Banyan Group, Inc. Springfield, Missouri, United States, 65807 United States, Nevada Renown Institute of Neurosciences Reno, Nevada, United States, 89502 United States, New York Dent Neurologic Institute Amherst, New York, United States, 14226 United States, Texas Baylor University Medical Center Dallas, Texas, United States, 75231 Less <<
NCT02908087 Type 1 Diabetes Phase 2 Enrolling by invitation July 2018 Finland ... More >> University of Oulu and Oulu University Hospital, Dept of Children and Adolescents Oulu, Finland, 90029 University of Tampere and Tampere University Hospital Tampere, Finland, 33520 University of Turku and Turku University Hospital Turku, Finland, 20520 Sweden Lund University and Skåne University Hospital Malmö, Sweden, 205 02 Less <<
NCT01381926 - Terminated(unavailability of s... More >>tudy drug and matching placebo) Less << - -
NCT01329562 Menstrual Migraine Phase 4 Completed - United States, Missouri ... More >> Clinvest Springfield, Missouri, United States, 65807 United States, Ohio University Internal Medicine Associates, Inc. Cincinnati, Ohio, United States, 45267-0535 Less <<
NCT00325104 Hypercalcemia ... More >> Familial Primary Hyperparathyroidism Less << Phase 3 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01381926 Type 2 Diabetes Mellitus ... More >> Bone Remodeling Less << Phase 4 Terminated(unavailability of s... More >>tudy drug and matching placebo) Less << - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 Less <<
NCT01329562 - Completed - -
NCT02898506 Type 1 Diabetes Phase 2 Enrolling by invitation July 2019 Finland ... More >> University of Oulu and Oulu University Hospital, Dept of Children and Adolescents Oulu, Finland, 90029 University of Tampere and Tampere University Hospital Tampere, Finland, 33520 University of Turku and Turku University Hospital Turku, Finland, 20520 Sweden Lund University and Skåne University Hospital Malmö, Sweden, 205 02 Less <<
NCT02611232 Type 1 Diabetes Phase 2 Enrolling by invitation June 2019 Finland ... More >> University of Oulu and Oulu University Hospital Oulu, Finland, 90029 University of Tampere and Tampere University Hospital Tampere, Finland, 33521 University of Turku and Turku University Hospital Turku, Finland, 20520 Less <<
NCT02466334 Cluster Headache Not Applicable Active, not recruiting December 2018 Denmark ... More >> Danish Headache Center Copenhagen, Glostrup, Denmark, 2600 Less <<
NCT01445067 Migraine Phase 1 Completed - United States, California ... More >> California Clinical Trials Medical Group Glendale, California, United States, 91206 Collaborative Neuroscience Network, Inc. Long Beach, California, United States, 90806 United States, Florida Compass Research, Llc Orlando, Florida, United States, 32806 United States, Ohio Community Research Cincinnati, Ohio, United States, 45255 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL

 

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