Benzisoxazole analogs are regarded as privileged structures in medicinal chemistry, and there has been a growing body of research on compounds containing benzisoxazole. Moreover, the distinctive benzisoxazole scaffold shows remarkable potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents, among others.

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[1]Rakesh K P, Shantharam C S, Sridhara M B, et al. Benzisoxazole: a privileged scaffold for medicinal chemistry[J]. MedChemComm, 2017, 8(11): 2023-2039.

[2]Albers L J, Musenga A, Raggi M A. Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market?[J]. Expert Opinion on Investigational Drugs, 2008, 17(1): 61-75.

[3]Uto Y. 1, 2-Benzisoxazole: A privileged structure with a potential for polypharmacology[J]. Current Pharmaceutical Design, 2016, 22(21): 3201-3211.

[4]Jain M, Kwon C H. 1, 2-Benzisoxazole phosphorodiamidates as novel anticancer prodrugs requiring bioreductive activation[J]. Journal of medicinal chemistry, 2003, 46(25): 5428-5436.