Piperidine plays a crucial role as a fundamental heterocyclic structure and serves as a critical foundation in drug manufacturing. Variations of piperidine are employed in diverse applications, including their use as agents for combating cancer, viruses, malaria, microbes, fungi, hypertension, pain, inflammation, Alzheimer's disease, psychosis, and/or blood clot prevention.

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Example Reaction of Piperidines:

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[1]Keri R S, Patil M R, Patil S A, et al. A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry[J]. European Journal of Medicinal Chemistry, 2015, 89: 207-251.

[2]Yoshida M, Hayakawa I, Hayashi N, et al. Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents[J]. Bioorganic & medicinal chemistry letters, 2005, 15(14): 3328-3332.

[3]Tariq S, Kamboj P, Amir M. Therapeutic advancement of benzothiazole derivatives in the last decennial period[J]. Archiv der Pharmazie, 2019, 352(1): 1800170.

[4]Khokra S L, Arora K, Mehta H, et al. Common methods to synthesize benzothiazole derivatives and their medicinal significance[J]. International Journal of Pharmaceutical Sciences and Research, 2011, 2(6): 1356-1378.