The Histone Acetyltransferase (HATs) family, including members such as GNAT, MYST, and CBP/p300, primarily resides in the cell nucleus, regulating chromatin structure and gene expression. By transferring acetyl groups onto lysine residues of histones, HATs promote chromatin relaxation, enabling transcription factors to access DNA and activate gene expression. These enzymes are involved in various biological processes and signaling pathways, such as cell cycle regulation, DNA repair, and gene transcription. The expression of HATs is tissue-specific, and dysfunction or gene mutations are closely associated with the development of diseases, including cancer and neurodegenerative disorders.