Chemistry Heterocyclic Building Blocks Pyridines 4,6-dichloropyridin-2-amine
Nucleophilic Substitution Reactions: The amino group can act as a nucleophile in substitution reactions, displacing one of the chloro substituents. This can lead to the formation of substituted pyridine derivatives.
Acylation Reactions: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Reductive Amination: The amine group can participate in reductive amination reactions with aldehydes or ketones to form secondary or tertiary amines, respectively.
Hofmann Rearrangement: The amine group can undergo Hofmann rearrangement under certain conditions to form substituted pyridines.
Halogenation Reactions: The chloro substituents can undergo further halogenation reactions under appropriate conditions.
Cross-Coupling Reactions: The amino group can participate in cross-coupling reactions such as Suzuki, Heck, or Stille coupling, leading to the formation of biaryl compounds.
Diazo Coupling: It can react with diazonium salts to form azo compounds.
Oxidation Reactions: Both the amine and chloro groups can undergo oxidation under suitable conditions.
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