Home Chemistry Organic Building Blocks Bromides Methyl 2-Bromo-5-Fluorobenzoate
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—COOCH3,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Reduction: Methyl benzoate can be reduced to benzyl alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). The ester functional group is reduced to an alcohol functional group.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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