Events & News

Events & News

Latest Innovations

Fe-Thiol Photocatalyzed Direct Decarboxylative Hydroalkylation: One-Step CF₃-Small-Ring Olefin Assembly

25 September 2025

Latest Innovations

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Recently, Prof. Dr. D. Katayev and Prof. Dr. J. G. West reported a catalytic approach for the direct decarboxylation of challenging CF3-cyclopropyl and cyclobutyl carboxylic acids using cooperative iron-thiol catalysis. This strategy enables the efficient generation of valuable radicals that can be incorporated into activated and unactivated alkenes, offering access to elusive chemical space. The corresponding key reagents and starting materials are now in stock at AmBeed, and we hope this advancement inspires your ongoing work.

Innovation

· First direct transfer of CF₃-containing small rings from their most abundant carboxylic acid surrogates.
· Overcame the challenging decarboxylation of CF₃-cyclopropyl and CF₃-cyclobutyl carboxylic acids.
· Leveraged the ligand-to-metal charge transfer (LMCT) excited state of photochemically activated iron complexes.
· Enabled efficient radical addition followed by hydrogen atom transfer (HAT) mediated by a thiol donor.
· Achieved, for the first time, facile hydroalkylation of alkenes with highly reactive CF₃-containing cyclopropyl and cyclobutyl radicals via iron-thiol cooperative catalysis.

Key Reagents

AmBeed's Products Support Related Research

AmBeed supplies a complete range of high-purity starting materials and reagents for the synthetic route described above—including the redox-active thiol (TRIP thiol), Tempo and cyclopropyl and cyclobutyl carboxylic acids—fully meeting your experimental needs and powering your research forward.

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References

[1]R. Giri, P.-K. Peng, A. J. Fernandes, etal. Overcoming Challenges in Small-Ring Transfer: Direct Decarboxylative Hydroalkylation of Alkenes via Iron-Thiol Catalysis. Angew. Chem. Int. Ed. 2025, 64, e202508377.

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