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[ CAS No. 1150271-33-2 ]

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Chemical Structure| 1150271-33-2
Chemical Structure| 1150271-33-2
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Product Details of [ 1150271-33-2 ]

CAS No. :1150271-33-2 MDL No. :MFCD12026064
Formula : C18H19BrN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :375.26 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1150271-33-2 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1150271-33-2 ]

  • Downstream synthetic route of [ 1150271-33-2 ]

[ 1150271-33-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 66698-28-0 ]
  • [ 501-53-1 ]
  • [ 1150271-33-2 ]
YieldReaction ConditionsOperation in experiment
With triethylamine In benzyl chloroformate Inert atmosphere; Cooling with ice; 3.1 EXAMPLE 3; trans-4-[4-(4-(Ethanesulphonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid (5-hydroxyadamantan-2-yl)amide (Compound No. °34); 3.1: 4-(4-Bromophenyl)piperazine-1-carboxylic acid benzyl ester; 5 g of 4-bromophenylpiperazine are placed in a 500 ml three-necked flask under a nitrogen atmosphere. 4.34 ml of triethylamine are added. The mixture is cooled in an ice bath and 3.24 ml of benzyl chloroformate are added. The mixture is allowed to return to ambient temperature. It is diluted with dichloromethane and then gentle hydrolysis is carried out. The aqueous phase is extracted with dichloromethane. The organic phases are combined, washed with a saturated NaCl solution, dried over sodium sulphate, then filtered through a sintered glass filter and concentrated under vacuum. 8.43 g of 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester are obtained.M+H+=376
  • 2
  • [ 887590-25-2 ]
  • [ 1150271-33-2 ]
  • [ 1187522-66-2 ]
YieldReaction ConditionsOperation in experiment
With sodium t-butanolate;tri-tert-butyl phosphine; palladium diacetate; In o-xylene; at 150℃; for 18h;Inert atmosphere; 3.2: 4-[4-(4-(Benzyloxycarbonyl)piperazin-1-yl)phenyl]-<strong>[887590-25-2]3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester</strong> 8.43 g of 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester are placed in a 500 ml three-necked flask under a nitrogen atmosphere. 170 ml of anhydrous o-xylene, 5.01 g of <strong>[887590-25-2]3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester</strong> and then 3.08 g of sodium tert-butoxide are added, followed by 0.48 g of palladium acetate, and then the addition is completed with 0.53 ml of tri(tert-butyl)phosphine. The reaction mixture is heated at 150 C. for 18 h. Heating is halted and the mixture is brought back to ambient temperature. The o-xylene is evaporated and the mixture is taken up in ethyl acetate before filtering it through celite. The organic phase is washed with water and then with a saturated aqueous sodium chloride solution. The aqueous phase is extracted with ethyl acetate. The organic phases are combined and then dried over sodium sulphate, filtered through a sintered glass filter and concentrated under vacuum. 8.9 g of 4-[4-(4-(Benzyloxycarbonyl)piperazin-1-yl)phenyl]-<strong>[887590-25-2]3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester</strong> are obtained after purification on a silica column, elution being carried out with a gradient of heptane/ethyl acetate solvent varying from 95/5 to 60/40). M+H+=529
  • 3
  • [ 104055-49-4 ]
  • [ 1150271-33-2 ]
YieldReaction ConditionsOperation in experiment
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 2h; 336 Benzyl 4-phenylpiperazine-1-carboxylate (2.1 g) was dissolved in DMF (80 ml), and N-bromosuccinimide (1.4 g) was added thereto, followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure and subjected to liquid separation by the addition of CHCl3 and a saturated aqueous sodium hydrogen carbonate solution. The organic layer was separated and dried over Na2SO4, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/EtOAc) to obtain benzyl 4-(4-bromophenyl)piperazine-1-carboxylate (2.3 g).
  • 4
  • [ 31166-44-6 ]
  • [ 589-87-7 ]
  • [ 1150271-33-2 ]
YieldReaction ConditionsOperation in experiment
82% With tris-(dibenzylideneacetone)dipalladium(0); Cs2CO3; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 90℃; for 12h; Inert atmosphere;
  • 5
  • [ 1150271-33-2 ]
  • [ 66698-28-0 ]
YieldReaction ConditionsOperation in experiment
83% With tripotassium phosphate tribasic; 2-hydroxyethanethiol In N,N-dimethyl acetamide at 75℃; for 24h; Inert atmosphere;
Historical Records

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Piperazines

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