Procollagen C-proteinase, also known as bone morphogenetic protein-1 (BMP-1), is a metalloproteinase responsible for cleaving the C-terminal peptides of procollagen molecules, promoting the formation of mature collagen. This enzyme belongs to the tolloid-like proteinase family and shares structural similarities with other family members such as mTLD and oTLD. BMP-1 is mainly located in the extracellular matrix and is widely present in connective tissues such as skin, bone, and cartilage. It is involved in various biological processes, including collagen maturation, extracellular matrix remodeling, and tissue repair. The specific expression and mutations of the gene are associated with various diseases, including osteogenesis imperfecta, scar formation, and tumor invasion.