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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 348622-88-8 Chemical Structure| 348622-88-8

Structure of UK-383367
CAS No.: 348622-88-8

Chemical Structure| 348622-88-8

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UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.

Synonyms: UK-383367

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of UK-383367

CAS No. :348622-88-8
Formula : C15H24N4O4
M.W : 324.38
SMILES Code : NC(C1=NOC([C@H](CCCC2CCCCC2)CC(NO)=O)=N1)=O
Synonyms :
UK-383367
MDL No. :MFCD19690945

Safety of UK-383367

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Target
  • Procollagen C Proteinase

    Procollagen C proteinase, IC50:44 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Human trabecular meshwork cells 1, 3, 5 μM 24 hours To determine whether TGF-β2-induced BMP1 enzyme activity is inhibited by UK-383367. Results showed TGF-β2 significantly increased BMP1 enzyme activity (P<0.05), and the BMP1 inhibitor blocked TGF-β2 induction of BMP1 enzyme activity (P<0.05). Invest Ophthalmol Vis Sci. 2013 Jul 16;54(7):4741-8.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Kunming mice Bacterial meningitis model Intravenous injection 4 mg/kg Single dose, 0.5 hour before BM induction UK383367 improved neurobehavioral outcomes, alleviated brain edema, preserved the integrity of BBB, and relieved the loss of AQP4 polarity in BM model. CNS Neurosci Ther. 2020 Dec;26(12):1288-1302

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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