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Chemical Structure| 51146-56-6 Chemical Structure| 51146-56-6

Structure of (S)-(+)-Ibuprofen
CAS No.: 51146-56-6

Chemical Structure| 51146-56-6

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(S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Synonyms: Dexibuprofen; (S)-Ibuprofen; (+)-Ibuprofen

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Product Details of (S)-(+)-Ibuprofen

CAS No. :51146-56-6
Formula : C13H18O2
M.W : 206.28
SMILES Code : [C@H](C1=CC=C(CC(C)C)C=C1)(C(O)=O)C
Synonyms :
Dexibuprofen; (S)-Ibuprofen; (+)-Ibuprofen
MDL No. :MFCD00069289
InChI Key :HEFNNWSXXWATRW-JTQLQIEISA-N
Pubchem ID :39912

Safety of (S)-(+)-Ibuprofen

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319-H335
Precautionary Statements:P260-P264-P270-P271-P280-P304+P340-P305+P351+P338-P312-P330-P403+P233-P501

Isoform Comparison

Biological Activity

Description
(S)-(+)-Ibuprofen, the S(+)-enantiomer of ibuprofen, is an effective inhibitor of both COX-1 and COX-2 enzymes, with IC50 values of 2.1 μM and 1.6 μM, respectively. It is recognized for its analgesic, anti-inflammatory, anticancer, and antipyretic properties[1][2].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02956525 Healthy Volunteers PHASE1 COMPLETED 2018-07-01 Azidus laboratories Ltd., Vali... More >>nhos, S?o Paulo, 13271-130, Brazil Less <<
NCT02956512 Healthy Volunteers PHASE1 COMPLETED 2019-09-06 Azidus laboratories Ltd., Vali... More >>nhos, S?o Paulo, 03186010, Brazil Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.48mL

24.24mL

4.85mL

2.42mL

48.48mL

9.70mL

4.85mL

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