Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	151-18-8
Formula :	C₃H₆N₂
M.W :	70.09
SMILES Code :	N#CCCN
Synonyms :	BAPN
MDL No. :	MFCD00014820
InChI Key :	AGSPXMVUFBBBMO-UHFFFAOYSA-N
Pubchem ID :	1647

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H227-H302-H314-H361
Precautionary Statements:	P201-P202-P260-P264-P270-P271-P281-P305+P351+P338-P330-P331-P363-P370+P378-P403+P233-P501
Class:	8
UN#:	2735
Packing Group:	Ⅲ

Primary cardiac fibroblasts	500 µM	7 days	Inhibit HG-induced collagen protein upregulation	J Adv Res. 2023 Dec;54:223-237
Endothelial cells (C166 cells)	25 μg/mL BAPN and 10 nM Ang I/Ang II	24 hours	To investigate the role of MMP8 in Ang I/Ang II-induced VCAM1 expression, results showed Ang I upregulated VCAM1 expression via MMP8	Cells. 2022 Oct 14;11(20):3218
Vascular smooth muscle cells	25 μg/mL BAPN	24-48 hours	To investigate the role of MMP8 in BAPN/Ang II-induced SMC inflammation and apoptosis, results showed MMP8 increased SMC apoptosis via ROS generation	Cells. 2022 Oct 14;11(20):3218
Human valvular interstitial cells (VICs)	0.5 mM	24-hours pretreatment followed by continuous culture	To evaluate the effect of BAPN on oxidative stress and calcification in VICs. Results showed that BAPN significantly reduced superoxide anion levels and calcium deposition.	Antioxidants (Basel). 2024 Apr 26;13(5):523
HT22 cells	1 mM	30 minutes	Inhibited LysOX activity, reduced glutamate- or erastin-induced neuronal death and lipid ROS accumulation.	Acta Pharm Sin B. 2022 Sep;12(9):3513-3528
LX-2 cells	1.0 mg/mL	48 hours	To evaluate the inhibitory effect of BAPN on LOXL2 and α-SMA expression in TGFβ-activated LX-2 cells. Results showed that BAPN significantly downregulated TGFβ-induced LOXL2 and α-SMA expression.	J Nanobiotechnology. 2023 Jun 16;21(1):195
Vascular smooth muscle cells	25 µg/mL	48 hours	To investigate the effect of BAPN on vascular smooth muscle cell phenotypic modulation, results showed that NE gene inactivation prevents BAPN-induced SMC phenotypic switching.	Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1900-1920

Mice	Intervertebral disc herniation injury model	Oral (via drinking water)	~125 mg/kg/day	From embryonic day 5.5 until postnatal day 5 (p5) or 14 (p14)	To inhibit collagen crosslinking density and evaluate its impact on disc regeneration. Results showed BAPN treatment reduced AF crosslinking density and tissue modulus in p14 mice, leading to fibrotic healing instead of regenerative healing.	iScience. 2024 Sep 4;27(10):110883
Mice	BAPN-induced thoracic aortic dissection model	Drinking water	0.25% BAPN (wt/vol)	4 weeks	To investigate the role of NE in BAPN-induced thoracic aortic dissection, results showed that NE gene deficiency prevents BAPN-induced TAD formation and development.	Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1900-1920
Mice	BAPN-induced TAA model	Oral	0.25% BAPN in water	Once daily for 4 weeks	BAPN successfully induced TAA and thoracic aortic dissection in mice.	Nat Commun. 2023 Apr 20;14(1):2265
Mice (ApoE−/−/MMP8−/−)	BAPN-induced thoracic aortic dissection model	Drinking water	0.25% wt/vol BAPN	Continuous for 4 weeks	To investigate the role of MMP8 in BAPN-induced thoracic aortic dissection, results showed MMP8 deficiency significantly reduced TAD incidence and aortic elastin fragmentation	Cells. 2022 Oct 14;11(20):3218
C57BL/6J mice	BAPN-induced aortic dissection model	Oral administration via drinking water	0.3% BAPN	Continuous for 4 weeks	The BAPN-induced aortic dissection model was used to study the pathological mechanisms of aortic dissection. Results showed that BAPN-induced mice exhibited significant aortic dilation and dissection, accompanied by abnormal expression of ferroptosis markers (HMOX1, ACSL4, and 4-HNE), as well as elevated levels of ferrous iron and lipid peroxidation.	Cell Death Dis. 2024 Dec 18;15(12):900
C57BL/6 mice	Abdominal aortic aneurysm model	Oral	0.4% BAPN drinking water	For 2 weeks	Induce abdominal aortic aneurysm formation	Clin Sci (Lond). 2023 Oct 11;137(19):1533-1545
C57BL/10 mice	BAPN-induced TAAD model	Drinking water	0.5 g/kg	Daily administration for 28 days	To study the pathogenesis and progression of TAAD, identifying the critical role of macrophages in TAAD development	Cell Discov. 2022 Feb 8;8(1):11
Mice (C57BL/6J)	Β-Aminopropionitrile monofumarate (BAPN)-induced TAD model	Drinking water	0.5 g/kg/day	Once daily for 28 days	Investigate the effect of KLF15 deficiency on BAPN-induced TAD. Results showed that KLF15-deficient mice had a significantly higher incidence of TAD (70%) compared to wild-type mice (35%), accompanied by aggravated aortic dilation and vascular inflammation.	J Biol Chem. 2024 May;300(5):107260
C57BL/6J mice	Β-Aminopropionitrile-induced thoracic aortopathy model	Drinking water	0.5% wt/vol	Continuous for 4 weeks	To investigate whether β-aminopropionitrile-induced thoracic aortopathies can be attenuated by inhibition of the renin-angiotensin system. Results showed that inhibition of either angiotensin II action or production did not attenuate β-aminopropionitrile-induced thoracic aortopathies.	Arterioscler Thromb Vasc Biol. 2022 Oct;42(10):1254-1261
Sprague-Dawley rats	TAAD model with BAPN pre-treatment and METH exposure	Intragastric administration	1 g/kg	Every 24 hours for 4 weeks	To establish a TAAD model with BAPN pre-treatment and METH exposure. Results showed that the combination of BAPN and METH caused thoracic aortic aneurysm/dissection in 60% of rats.	Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166447
Mice	BAPN-induced TAD mouse model	Drinking water	1 g/kg per day	Daily for 4 weeks	SGK1 deficiency or pharmacological blockade inhibits vascular degeneration and TAD progression, suppressing VSMC phenotypic transformation.	Arterioscler Thromb Vasc Biol. 2025 Feb;45(2):238-259
C57BL/6J mice	BAPN-induced thoracic aortic dissection model	Oral	1 g/kg/day	Once daily for 4 weeks	To study BAPN-induced thoracic aortic dissection formation, results showed BAPN promoted thoracic aortic dilation and dissection.	Mol Med. 2024 Sep 19;30(1):154
C57BL/6 mice	BAPN-induced aortic aneurysm and dissection (AAD) model	Oral administration via drinking water	1 g/kg/day	Once daily for four weeks	To evaluate the effect of miR-1204 inhibition on BAPN-induced AAD formation. Results showed that inhibition of miR-1204 reduced the incidence and mortality of AAD and attenuated vascular cell senescence.	Nat Commun. 2024 Jul 16;15(1):5985
C57BL/6 mice	Streptozotocin-induced diabetic model	Intraperitoneal injection	100 mg/kg/day	Every two days for 14 weeks	Inhibit Lox expression, alleviate cardiac dysfunction and fibrosis in diabetic mice	J Adv Res. 2023 Dec;54:223-237
BALB/c female mice	CCl4-induced liver fibrosis model	Tail vein injection	125 mg/kg	Once daily for 4 weeks	To evaluate the inhibitory effect of BAPN on LOXL2 expression and collagen crosslinking in CCl4-induced liver fibrosis model. Results showed that BAPN significantly reduced serum LOXL2 levels and LOXL2 and Col1A2 expression in the liver, and partially decreased collagen deposition.	J Nanobiotechnology. 2023 Jun 16;21(1):195
C57BL/6J mice	BAPN-induced TAD model	Oral administration via drinking water	1g/kg/day	Consecutive 4 weeks	Establish TAD model for studying the role of NINJ1 in TAD formation.	BMC Med. 2023 Oct 20;21(1):396
Mice	Fbn1C1041G/+ mice and wild-type (WT) mice	Intraperitoneal injection	300 mg/kg	Daily for 8 weeks	To test the effects of BAPN on optic nerve and elastic fibers in Fbn1C1041G/+ and WT mice. Results showed that BAPN treatment exacerbated optic nerve and axon expansion in Fbn1C1041G/+ mice and altered the ultrastructure of elastic fibers in the optic nerve pia mater.	Am J Pathol. 2024 Jul;194(7):1317-1328
C57BL/6J mice	Acute aortic dissection model	Drinking water	5 g/L (drinking water)	Continuous administration	Induce acute aortic dissection and observe immune response	Sci Rep. 2024 Jun 28;14(1):14893
C57BL/6J mice	KA-induced seizure mouse model	Intraperitoneal injection	50 or 100 mg/kg	Once daily for seven days	Significantly blocked seizure-induced ferroptosis and alleviated neuronal damage.	Acta Pharm Sin B. 2022 Sep;12(9):3513-3528

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CAS No.: 151-18-8

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CAS No.: 151-18-8

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	14.27mL 2.85mL 1.43mL	71.34mL 14.27mL 7.13mL	142.67mL 28.53mL 14.27mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2 The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed