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Chemical Structure| 2418594-00-8 Chemical Structure| 2418594-00-8

Structure of (1R,2R)-ML-SI3
CAS No.: 2418594-00-8

Chemical Structure| 2418594-00-8

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(1R,2R)-ML-SI3 is an effective inhibitor of TRPML1 and TRPML2, with IC50 values of 1.6 μM and 2.3 μM, respectively, and weaker inhibition of TRPML3 with an IC50 of 12.5 μM.

Synonyms: (-)-trans-ML-SI3

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Product Details of (1R,2R)-ML-SI3

CAS No. :2418594-00-8
Formula : C23H31N3O3S
M.W : 429.58
SMILES Code : O=S(C1=CC=CC=C1)(N[C@H]2[C@H](N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O
Synonyms :
(-)-trans-ML-SI3
MDL No. :N/A

Safety of (1R,2R)-ML-SI3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2, with IC50 values of 1.6 and 2.3 μM, respectively, and a weak inhibitor (IC50 12.5 μM) of TRPML3[1].

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2.33mL

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2.33mL

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