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Chemical Structure| 4235-95-4 Chemical Structure| 4235-95-4

Structure of 4235-95-4

Chemical Structure| 4235-95-4

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1,2-DOPC is a phospholipid utilized for liposome production.

Synonyms: DOPC; sn-3-Dioleoyllecithin; PC(18:1(9Z)/18:1(9Z))

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Product Citations

Product Citations

Conthagamage, Udyogi NK ; Rajeshwar T, Rajitha ; van der Ham, Stijn ; Akhtar, Nasim ; Davis, Macallister L ; Jayawardana, Senuri G , et al.

Abstract: Rotaxanes equipped with actuators hold great potential for developing highly functional molecular machines. Such systems could significantly enhance our ability to study and manipulate biological and artificial membranes. Here, we introduce a rotaxane with a ring featuring two azobenzene photoswitches, which retain their photoreversibility and can be stochastically shuttled along the axle in solution. Studies in model bilayers, supported by molecular dynamics simulations, show how azobenzene photoswitching alters the interaction of rotaxanes with surrounding lipids, leading to changes in lipid packing. Such changes in the lipid bilayer were leveraged to induce the light-triggered release of sulforhodamine B from large unilamellar vesicles. Additionally, light activation of the rotaxanes is shown to induce reversible contraction and expansion of giant unilamellar vesicles. The results provide novel insights into the interactions and operation of rotaxanes in lipid bilayers and their impact on membrane properties. This will aid in developing systems for precise membrane manipulation for applications in biomedicine and bioengineering.

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Product Details of 1,2-Dioleoyl-sn-glycero-3-phosphocholine

CAS No. :4235-95-4
Formula : C44H84NO8P
M.W : 786.11
SMILES Code : CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
Synonyms :
DOPC; sn-3-Dioleoyllecithin; PC(18:1(9Z)/18:1(9Z))
MDL No. :MFCD00135191
InChI Key :SNKAWJBJQDLSFF-NVKMUCNASA-N
Pubchem ID :10350317

Safety of 1,2-Dioleoyl-sn-glycero-3-phosphocholine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.36mL

1.27mL

0.64mL

12.72mL

2.54mL

1.27mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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