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Chemical Structure| 19130-96-2 Chemical Structure| 19130-96-2

Structure of 1-Deoxynojirimycin
CAS No.: 19130-96-2

Chemical Structure| 19130-96-2

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1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. It's a natural product isolated and purified from the root barks of Morus alba L..

Synonyms: Duvoglustat; BAY-h-5955; Moranoline

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Product Details of 1-Deoxynojirimycin

CAS No. :19130-96-2
Formula : C6H13NO4
M.W : 163.17
SMILES Code : O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O
Synonyms :
Duvoglustat; BAY-h-5955; Moranoline
MDL No. :MFCD00063474
InChI Key :LXBIFEVIBLOUGU-JGWLITMVSA-N
Pubchem ID :29435

Safety of 1-Deoxynojirimycin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HCM iPSC-CMs 30 μM 24 h DNJ significantly increased mitochondrial membrane potential (MMP) and enhanced ATP production. J Clin Invest. 2023 Jul 17;133(14):e164660
HCM cybrids 30 μM 24 h DNJ significantly increased mitochondrial membrane potential (MMP) and enhanced ATP production. J Clin Invest. 2023 Jul 17;133(14):e164660

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wanxi white geese 12-day-old male Wanxi white geese Dietary supplementation 0.05 mg/g, 0.1 mg/g, 0.15 mg/g Daily for 6 weeks To investigate the effect of 1-deoxynojirimycin on the digestive system of geese. Results showed that DNJ decreased body and liver weight, increased feed conversion ratio, affected nutrient metabolism, and altered gut microbiota composition. Poult Sci. 2020 Nov;99(11):5858-5866
Japanese white rabbits Myocardial ischemia-reperfusion model Intravenous injection 100 mg/kg Single dose, 10 min before ischemia To assess the effect of MOR-14 on infarct size, results showed MOR-14 significantly reduced infarct size (17±2% vs 46±5%). Br J Pharmacol. 2001 Jul;133(5):635-42

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00688597 Pompe Disease PHASE2 TERMINATED 2009-12-14 Decatur, Georgia, 30033, Unite... More >>d States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.13mL

1.23mL

0.61mL

30.64mL

6.13mL

3.06mL

61.29mL

12.26mL

6.13mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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