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[ CAS No. 1001907-57-8 ]

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Chemical Structure| 1001907-57-8
Chemical Structure| 1001907-57-8
Structure of 1001907-57-8 * Storage: {[proInfo.prStorage]}

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Product Details of [ 1001907-57-8 ]

CAS No. :1001907-57-8 MDL No. :MFCD09870057
Formula : C8H9BN2O2 Boiling Point : 430.8°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :175.98 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1001907-57-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1001907-57-8 ]

  • Downstream synthetic route of [ 1001907-57-8 ]

[ 1001907-57-8 ] Synthesis Path-Downstream   1~6

  • 2
  • [ 1001907-57-8 ]
  • 4-bromo-1-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indole-6-carboxamide [ No CAS ]
  • 1-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-4-(2-methyl-2H-indazol-6-yl)-1H-indole-6-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 80 - 85℃; for 16.5h; Inert atmosphere; 59 Example 59: l-Isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-l,2-dihydropyridin-3-yl)methyl)- 4-(2-methyl-2H-indazol-6-yl)-lH-indole-6-carboxamide To a solution of 4-bromo-l-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-l,2-dihydro pyridin-3-yl)methyl)-lH-indole-6-carboxamide (Example 30, 300 mg, 0.654 mmol) and (2-methyl-2H-indazol-6-yl)boronic acid (161 mg, 0.916 mmol) in 1,4-dioxane (5 mL) was added water (2.500 mL) and bubbled argon gas for 30 minutes. PdCl2(dppf)-CH2Cl2 adduct (53.4 mg, 0.065 mmol) was added and the reaction mass was stirred at 80-85 °C for 16 h. After completion of reaction, the reaction mixture was cooled to RT, filtered through celite, added water, extracted with ethyl acetate, concentrated and purified by column chromatography (silica gel, 5 % MeOH in chloroform) to obtain the title compound. Yield: 148 mg (29 ); JH NMR (CDC13, 300 MHz): δ 11.48 (s, 1H), 8.35 (s, 1H), 8.08 (s, 1H), 7.78 (d, 1H, J=8.7Hz), 7.71 (s, 1H), 7.62 (s, 1H), 7.29 (d, 1H, J=8.7Hz), 6.98 (s, 1H), 6.55 (s, 1H), 5.88 (s, 1H), 5.20 (m, 1H), 4.31 (s, 2H), 4.18 (s, 3H), 2.68 (s, 3H), 2.10 (s, 3H), 2.03 (m, 2H), 1.54 (m, 2H), 1.48 (d, 6H, J=6.6Hz), 0.95 (t, 3H, J=4.2 Hz); MS (ESI+): m/z 511 (M+l)+; HPLC purity: 88.88 %.
  • 4
  • [ 7342-82-7 ]
  • [ 1001907-57-8 ]
  • 6-(benzo[b]thiophen-3-yl)-2-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
90 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane In methanol; N,N-dimethyl acetamide at 80℃; Inert atmosphere; Glovebox;
  • 5
  • [ 1001907-57-8 ]
  • [ 17321-77-6 ]
  • N,N-dimethyl-3-(3-(2-methyl-2H-indazol-6-yl)-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
96 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane In 2-methyltetrahydrofuran; methanol at 80℃; for 18h; Inert atmosphere; Glovebox;
  • 6
  • [ 49562-28-9 ]
  • [ 1001907-57-8 ]
  • isopropyl 2-methyl-2-(4-(4-(2-methyl-2H-indazol-6-yl)benzoyl)phenoxy)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
92 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane In 2-methyltetrahydrofuran; methanol at 80℃; Inert atmosphere; Glovebox;
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