630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic ReagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen SodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam BesylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic DyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriptycene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF LigandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Heterocyclic Building Blocks
Organoboron
2-methyl-2H-indazole
(2-Methyl-2H-indazol-6-yl)boronic acid
Chemistry
Heterocyclic Building Blocks
Organometallic Reagents Boronic acids/esters
Organoboron
Indazoles Aromatic Borons
2-methyl-2H-indazole

[ CAS No. 1001907-57-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1001907-57-8
Chemical Structure| 1001907-57-8
Structure of 1001907-57-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 1001907-57-8 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1001907-57-8 ]

SDS Specification
Alternatived Products of [ 1001907-57-8 ]

Product Details of [ 1001907-57-8 ]

CAS No. :1001907-57-8 MDL No. :MFCD09870057
Formula : C8H9BN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :JADBVQWCMHPPQA-UHFFFAOYSA-N
M.W : 175.98 Pubchem ID :44630579
Synonyms :

Safety of [ 1001907-57-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1001907-57-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1001907-57-8 ]

[ 1001907-57-8 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 1001907-57-8 ]
  • [ 916451-11-1 ]
  • C33H37N5O5Si [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In water; acetonitrile
Reference： [1]Location in patent: scheme or table Yu, Wensheng; Tong, Ling; Kim, Seong Heon; Wong, Michael K.C.; Chen, Lei; Yang, De-Yi; Shankar, Bandarpalle B.; Lavey, Brian J.; Zhou, Guowei; Kosinski, Aneta; Rizvi, Razia; Li, Dansu; Feltz, Robert J.; Piwinski, John J.; Rosner, Kristin E.; Shih, Neng-Yang; Siddiqui, M. Arshad; Guo, Zhuyan; Orth, Peter; Shah, Himanshu; Sun, Jing; Umland, Shelby; Lundell, Daniel J.; Niu, Xiaoda; Kozlowski, Joseph A. [Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5286 - 5289]
  • 2
  • [ 1001907-57-8 ]
  • 4-bromo-1-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indole-6-carboxamide [ No CAS ]
  • 1-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-4-(2-methyl-2H-indazol-6-yl)-1H-indole-6-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 80 - 85℃; for 16.5h; Inert atmosphere; 59 Example 59: l-Isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-l,2-dihydropyridin-3-yl)methyl)- 4-(2-methyl-2H-indazol-6-yl)-lH-indole-6-carboxamide To a solution of 4-bromo-l-isopropyl-7-methyl-N-((6-methyl-2-oxo-4-propyl-l,2-dihydro pyridin-3-yl)methyl)-lH-indole-6-carboxamide (Example 30, 300 mg, 0.654 mmol) and (2-methyl-2H-indazol-6-yl)boronic acid (161 mg, 0.916 mmol) in 1,4-dioxane (5 mL) was added water (2.500 mL) and bubbled argon gas for 30 minutes. PdCl2(dppf)-CH2Cl2 adduct (53.4 mg, 0.065 mmol) was added and the reaction mass was stirred at 80-85 °C for 16 h. After completion of reaction, the reaction mixture was cooled to RT, filtered through celite, added water, extracted with ethyl acetate, concentrated and purified by column chromatography (silica gel, 5 % MeOH in chloroform) to obtain the title compound. Yield: 148 mg (29 ); JH NMR (CDC13, 300 MHz): δ 11.48 (s, 1H), 8.35 (s, 1H), 8.08 (s, 1H), 7.78 (d, 1H, J=8.7Hz), 7.71 (s, 1H), 7.62 (s, 1H), 7.29 (d, 1H, J=8.7Hz), 6.98 (s, 1H), 6.55 (s, 1H), 5.88 (s, 1H), 5.20 (m, 1H), 4.31 (s, 2H), 4.18 (s, 3H), 2.68 (s, 3H), 2.10 (s, 3H), 2.03 (m, 2H), 1.54 (m, 2H), 1.48 (d, 6H, J=6.6Hz), 0.95 (t, 3H, J=4.2 Hz); MS (ESI+): m/z 511 (M+l)+; HPLC purity: 88.88 %.
Reference： [1]Current Patent Assignee: PIRAMAL ENTERPRISES LIMITED - WO2015/104677, 2015, A1 Location in patent: Page/Page column 97
  • 3
  • [ 1001907-57-8 ]
  • tert-butyl (S)-2-(((2-chloro-5-iodopyridin-4-yl)amino)methyl)morpholine-4-carboxylate [ No CAS ]
  • C23H28ClN5O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile at 100℃; for 0.333333h; Microwave irradiation;
Reference： [1]Osborne, James D.; Matthews, Thomas P.; McHardy, Tatiana; Proisy, Nicolas; Cheung, Kwai-Ming J.; Lainchbury, Michael; Brown, Nathan; Walton, Michael I.; Eve, Paul D.; Boxall, Katherine J.; Hayes, Angela; Henley, Alan T.; Valenti, Melanie R.; De Haven Brandon, Alexis K.; Box, Gary; Jamin, Yann; Robinson, Simon P.; Westwood, Isaac M.; Van Montfort, Rob L. M.; Leonard, Philip M.; Lamers, Marieke B. A. C.; Reader, John C.; Aherne, G. Wynne; Raynaud, Florence I.; Eccles, Suzanne A.; Garrett, Michelle D.; Collins, Ian [Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5221 - 5237]
  • 4
  • [ 7342-82-7 ]
  • [ 1001907-57-8 ]
  • 6-(benzo[b]thiophen-3-yl)-2-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
90 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane In methanol; N,N-dimethyl acetamide at 80℃; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 5
  • [ 1001907-57-8 ]
  • [ 17321-77-6 ]
  • N,N-dimethyl-3-(3-(2-methyl-2H-indazol-6-yl)-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
96 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane In 2-methyltetrahydrofuran; methanol at 80℃; for 18h; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 6
  • [ 49562-28-9 ]
  • [ 1001907-57-8 ]
  • isopropyl 2-methyl-2-(4-(4-(2-methyl-2H-indazol-6-yl)benzoyl)phenoxy)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
92 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane In 2-methyltetrahydrofuran; methanol at 80℃; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 7
  • [ 1001907-57-8 ]
  • [ 58-39-9 ]
  • 2-(4-(3-(2-(2-methyl-2H-indazol-6-yl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
99 %Chromat. With 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene In 2-methyltetrahydrofuran; methanol at 80℃; Inert atmosphere; Glovebox; Large scale;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 8
  • [ 10075-51-1 ]
  • [ 1001907-57-8 ]
  • 6-(1-benzyl-1H-indol-5-yl)-2-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
52% With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane In methanol; N,N-dimethyl acetamide at 80℃; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 9
  • 1-bromo-2,6-difluoro4-methoxybenzene [ No CAS ]
  • [ 1001907-57-8 ]
  • 6-(2,6-difluoro-4-methoxyphenyl)-2-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
76 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,2-bis-(diphenylphosphino)ethane In 2-methyltetrahydrofuran; methanol at 80℃; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 10
  • [ 59214-70-9 ]
  • [ 1001907-57-8 ]
  • 6-(benzofuran-3-yl)-2-methyl-2H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
93 %Chromat. With nickel(II) chloride hexahydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane In methanol; N,N-dimethyl acetamide at 80℃; Inert atmosphere; Glovebox;
Reference： [1]Goldfogel, Matthew J.; Guo, Xuelei; Meléndez Matos, Jeishla L.; Gurak, John A.; Joannou, Matthew V.; Moffat, William B.; Simmons, Eric M.; Wisniewski, Steven R. [Organic Process Research and Development, 2022, vol. 26, # 3, p. 785 - 794]
  • 11
  • [ 1001907-57-8 ]
  • C22H23BrFN3O3S [ No CAS ]
  • C30H30FN5O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous sodium carbonate In 1,4-dioxane; lithium hydroxide monohydrate at 100℃; for 12h; Inert atmosphere; 36.1 first step Compound 21-7 (241 mg, 474 μmol), compound 36-1 (100 mg, 568 μmol) and sodium carbonate (100 mg, 947 μmol) were dissolved in dioxane (8.00 mL) and water (2.00 mL) under nitrogen protection. 1,1-bis(diphenylphosphonium)ferrocene palladium chloride (34.6 mg, 47.3 μmol) was added to the reaction solution, and the reaction solution was stirred at 100° C. for 12 hours. The reaction solution was concentrated under reduced pressure, and the residue was separated and purified by silica gel column chromatography (1/1, petroleum ether/ethyl acetate, Rf=0.29) to obtain compound 36-2.
Reference： [1]Current Patent Assignee: WUXI APPTEC CO., LTD. - WO2022/188709, 2022, A1 Location in patent: Page/Page column 77

Tags: 1001907-57-8 synthesis path| 1001907-57-8 SDS| 1001907-57-8 COA| 1001907-57-8 purity| 1001907-57-8 application| 1001907-57-8 NMR| 1001907-57-8 COA| 1001907-57-8 structure

Same Skeleton Products
Related Products
Categories
Chemistry
Heterocyclic Building Blocks
Indazoles
2-methyl-2H-indazole
Chemistry
Organometallic Reagents
Organoboron
Chemistry
Boronic acids/esters
Aromatic Borons
Historical Records