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Chemical Structure| 1002984-09-9 Chemical Structure| 1002984-09-9

Structure of 1002984-09-9

Chemical Structure| 1002984-09-9

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Product Details of [ 1002984-09-9 ]

CAS No. :1002984-09-9
Formula : C19H22O4
M.W : 314.38
SMILES Code : O=C(OCC)C1=CC=C(OCC2=CC=CC=C2)C(OC(C)C)=C1
MDL No. :MFCD32691106

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Application In Synthesis of [ 1002984-09-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1002984-09-9 ]

[ 1002984-09-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 177429-27-5 ]
  • [ 75-26-3 ]
  • [ 1002984-09-9 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 4h; (1-1) Synthesis of Compound (5a) Compound (3) (50 g, 184 mmol) , DMF (500 ml), and potassium carbonate (76.1 g, 3 eq.) were introduced into a reaction vessel. Isopropyl bromide (4a) (51.7 ml, 3 eq. ) was added thereto, and the mixture was heated at about 80C for 4 hours. After the mixture was cooled to room temperature, water (500 ml) was added thereto to dissolve inorganic salt. AcOEt (500 ml) was then added thereto, and extraction and liquid separation was performed. The organic layer was washed with water (500 ml) twice, and then concentrated to dryness to obtain an oily product of ethyl 4- (benzyloxy) -3-isopropoxybenzoate. EtOH (500 ml) was added to the resulting oil and dissolved. A 25% NaOH aqueous solution (50 ml) was added thereto, and the mixture was heated under stirring at 50C or more for about 1 hour. After the completion of the reaction, water (250 ml) and concentrated hydrochloric acid (50 ml) were added. After the reaction mixture was cooled, the precipitated crystals were collected by filtration and dried at 80C to give crystal Compound (5a) (48.65 g). Compound (5a): XH NMR (CDC13, 300 MHz) delta 1.39 (d, J = 6.0 Hz, 6H) , 4.61 (sept, J = 6.0 Hz, 1H), 5.21 (s, 2H) , 6.94 (d, J = 8.4 Hz, 1H) , 7.29-7.45 (m, 5H), 7.65 (d, J = 2.1 Hz, 2H) , 7.69 (dd, J = 8.4 Hz, 2.1 Hz, 2H).
 

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