Alternatived Products of [ 1003843-94-4 ]
Product Details of [ 1003843-94-4 ]
CAS No. : | 1003843-94-4 |
MDL No. : | MFCD26051392 |
Formula : |
C9H9F3O3S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
254.22
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1003843-94-4 ]
Application In Synthesis of [ 1003843-94-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1003843-94-4 ]
- 1
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[ 172023-97-1 ]
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[ 20277-69-4 ]
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[ 1003843-94-4 ]
Yield | Reaction Conditions | Operation in experiment |
69% |
With copper(l) iodide; sodium L-prolinate; In dimethyl sulfoxide; at 95℃; for 20h; |
To a solution of <strong>[172023-97-1](3-bromo-5-trifluoromethyl-phenyl)-methanol</strong> (2 mmol, 613 mg), L- proline sodium salt (0.4 mmol, 55 mg), copper iodide (0.2 mmol, 38 mg) in DMSO (4 mL) is added sodium methanesulfinate (2.4 mmol, 245 mg) under nitrogen. The solution is allowed to warm to 95 0C and stirred for 20 hours. The mixture is cooled to room temperature, then added water. The mixture is extracted with dichloromethane. The combined organic layer is washed with brine, dried over Na2SO4, filtrated, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (eluent: hexane / EtOAc) to give (3-methanesulfonyl-5-trifluoromethyl-phenyl)-methanol (418 mg, 69%); ESI-MS m/z: 255 [M+1]+, Retention time 1.64 min (condition A). |
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