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CAS No. : | 1005756-81-9 | MDL No. : | MFCD06739026 |
Formula : | C7H16ClNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 165.66 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | N/A | |
Precautionary Statements: | UN#: | N/A | |
Hazard Statements: | Packing Group: | N/A |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35% | With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 10h; | 12 [0265] A mixture of chloride (R)-benzyl 4-(2-((2,6-dichloronicotinamido)methyl)pyrrolidin-1-yl)-4- oxobutylcarbamate (150 mg, 0.304 mmol), 2-(tetrahydro-2H-pyran-2-yl)ethanamine HCI salt (76 mg, 0.459 mmol), K2CO3 (125 mg, 0.905 mmol) and DMF (1 mL) was stirred at 10O0C for 10 hrs. The crude mixture was purified on RP-HPLC using a mixture of acetonitrile and H2O to give benzyl 4-((R)-2-((6-chloro-2-(2-(tetrahydro-2H-pyran-2- yl)ethylamino)nicotinamido)methyl)pyrrolidin-1-yl)-4-oxobutylcarbamate (62 mg, 35%). LRMS (M+H+) m/z 586.3. |