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Chemical Structure| 1007571-40-5 Chemical Structure| 1007571-40-5

Structure of 1007571-40-5

Chemical Structure| 1007571-40-5

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Product Details of [ 1007571-40-5 ]

CAS No. :1007571-40-5
Formula : C9H11BrF2Si
M.W : 265.17
SMILES Code : C[Si](C)(C1=CC=C(Br)C(F)=C1F)C
MDL No. :MFCD30178762

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Application In Synthesis of [ 1007571-40-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1007571-40-5 ]

[ 1007571-40-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-77-4 ]
  • [ 38573-88-5 ]
  • [ 1007571-40-5 ]
YieldReaction ConditionsOperation in experiment
Example 2Preparation of (4-bromo-2,3-difluorophenyl)trimethylsilaneDiisopropylamine (7.86 grams (g), 78 mmol) was dissolved in tetrahydrofuran (THF; 104 mL) and cooled to -75° C. utilizing a dry ice/acetone bath.A solution of n-BuLi (2.5 M in hexanes; 22.80 mL, 57.0 mmol) was added dropwise, and the solution was again cooled to -75° C. 1-Bromo-2,3-difluorobenzene (10 g, 51.8 mmol) was dissolved in THF (25.9 mL), and the solution was added dropwise keeping the temperature below -60° C.The reaction mixture was then allowed to warm to -15° C. before cooling again to -75° C. TMSCl (7.29 mL, 57.0 mmol) was then added dropwise, and the reaction mixture was allowed to warm to 25° C. and then concentrated under vacuum.The residue was partitioned between ethyl acetate (EtOAc) and H2O.The organic phase was washed twice more with H2O and concentrated.Kugelrohr distillation at 88° C. provided the product in greater purity but an impurity was distilling at that temperature.Kugelrohr distillation of that purified distillate at 75° C. led to purer product but some product was left in the pot.This process yielded the title compound as a clear oil (3.0 g, 21.83percent, 90percent purity): 1H NMR (300 MHz, CDCl3) delta 7.28 (ddd, J=7.8, 5.2, 1.3 Hz, 1H), 6.98 (ddd, J=8.0, 4.8, 1.9 Hz, 1H), 0.32 (s, 9H); EIMS m/z 264, 266.
 

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