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[ CAS No. 1008361-81-6 ]

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Chemical Structure| 1008361-81-6
Chemical Structure| 1008361-81-6
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Product Details of [ 1008361-81-6 ]

CAS No. :1008361-81-6 MDL No. :MFCD12828061
Formula : C7H4BrClN2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :231.48 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1008361-81-6 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H320-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1008361-81-6 ]

  • Downstream synthetic route of [ 1008361-81-6 ]

[ 1008361-81-6 ] Synthesis Path-Downstream   1~14

  • 1
  • [ 110-87-2 ]
  • [ 1008361-81-6 ]
  • [ 1425933-18-1 ]
YieldReaction ConditionsOperation in experiment
90% With camphorsulfonic acid In tetrahydrofuran for 16h; Reflux; 13.2 step 2: To a solution of 128 (22 g, 0.095 mol) in dry THF (660 mL) was added 3,4-dihydro-2H-pyran (24 g, 0.286 mol) and camphorsulfonic acid (2.2 g, 0.00948 mol) and the solution was heated to reflux for 16 h. The resulting mixture was concentrated, and the residue obtained was purified by Si02 chromatography eluting with 20% EtO Ac/petroleum ether to afford 27 g (90%) of 5-bromo-4-chloro-l- (tetrahydro-pyran-2-yl)-lH-benzoimidazole (130) as pale yellow solid.
27 g With camphor-10-sulfonic acid In tetrahydrofuran at 60℃; for 16h;
  • 2
  • [ 64-18-6 ]
  • [ 1008361-80-5 ]
  • [ 1008361-81-6 ]
YieldReaction ConditionsOperation in experiment
for 1.5h;Reflux; Example 13 N2 -[(4-Chloro-lH-benzimidazol-5-yl)methyl]- N4 -(5-cyclopropyl-lH-pyrazol-3-yl)pyrimidine-2,4- diamine (1-3) step 1 : A mixture of 4-bromo-3-chloro-benzene-l,2-diamine (CASRN 1008361-80-5, 27 g, 0.1221 mol) and formic acid (80 mL) was heated to reflux for 1.5 h. After the completion of the reaction, 10% NaOH was added until the solution basic. The resulting solid was filtered and washed well with water then dried over night over suction to afford 22 g (78%) of 5-bromo-4-chloro-lH-benzoimidazole (128) as pale yellow solid which was used without additional purification.
  • 3
  • [ 1008361-81-6 ]
  • [ 1425933-20-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere
Multi-step reaction with 2 steps 1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C
  • 4
  • [ 1008361-81-6 ]
  • [ 1425933-21-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr
Multi-step reaction with 3 steps 1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3: nickel; hydrogen; ammonia / methanol / 16 h
  • 5
  • [ 1008361-81-6 ]
  • [ 1425928-86-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 140 °C / Sealed tube 5: toluene-4-sulfonic acid / methanol / 100 °C / Sealed tube
Multi-step reaction with 5 steps 1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3: nickel; hydrogen; ammonia / methanol / 16 h 4: N-ethyl-N,N-diisopropylamine / butan-1-ol / Sealed tube 5: toluene-4-sulfonic acid / methanol
  • 6
  • [ 1008361-81-6 ]
  • [ 1425933-22-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 140 °C / Sealed tube
Multi-step reaction with 4 steps 1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3: nickel; hydrogen; ammonia / methanol / 16 h 4: N-ethyl-N,N-diisopropylamine / butan-1-ol / Sealed tube
  • 7
  • [ 1008361-81-6 ]
  • [ 1425933-46-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C
Multi-step reaction with 4 steps 1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3: nickel; hydrogen; ammonia / methanol / 16 h 4: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C
  • 8
  • [ 1008361-81-6 ]
  • [ 1425933-47-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3.1: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 20 °C 5.2: 0 - 20 °C
Multi-step reaction with 5 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C
  • 9
  • [ 1008361-81-6 ]
  • 1-(4-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)-N-methylmethanamine dihudrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3.1: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 20 °C 5.2: 0 - 20 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C
Multi-step reaction with 6 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 23 °C
  • 10
  • [ 1008361-81-6 ]
  • [ 1425929-73-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: camphorsulfonic acid / tetrahydrofuran / 16 h / Reflux 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere 3.1: ammonia; hydrogen / methanol / 16 h / 3750.38 Torr 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 20 °C 5.2: 0 - 20 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C 7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 96 h / 120 °C
  • 11
  • [ 1008361-81-6 ]
  • C24H27ClN8O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 23 °C 7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / Sealed tube
  • 12
  • [ 1008361-81-6 ]
  • N-((4-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methyl)ethanamine dihydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 23 °C
  • 13
  • [ 1008361-81-6 ]
  • C20H28ClN3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C
  • 14
  • [ 1008361-81-6 ]
  • C25H29ClN8O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C 2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 6 h / 110 °C 3.1: nickel; hydrogen; ammonia / methanol / 16 h 4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C 5.2: 6 h / 0 - 23 °C 6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 23 °C 7.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / Sealed tube
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