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Chemical Structure| 1015480-67-7 Chemical Structure| 1015480-67-7

Structure of 1015480-67-7

Chemical Structure| 1015480-67-7

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Product Details of [ 1015480-67-7 ]

CAS No. :1015480-67-7
Formula : C14H12ClN3O2
M.W : 289.72
SMILES Code : COC1=CC=C(C2=C3N=C(Cl)C=CN3N=C2)C=C1OC
English Name :5-Chloro-3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine
MDL No. :MFCD26399153

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Application In Synthesis of [ 1015480-67-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1015480-67-7 ]

[ 1015480-67-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1015480-67-7 ]
  • [ 200352-28-9 ]
  • [ 1015480-48-4 ]
YieldReaction ConditionsOperation in experiment
In 1-methyl-pyrrolidin-2-one at 140℃; for 0.166667h; Microwave oven; 1 Example 1: (^^^^-^-(S^-Dimethoxy-phenyO-pyrazololi.S-alpyrimidin-S-ylamino]- cyclohexanol:5-Chloro-3-(3,4-dimethoxy-phenyl)-pyrazolo[1 ,5-a]pyrimidine (C) ( 25 mg; 0.086 mmol) and (as amino starting material) cis-2-aminocyclohexanol HCI (ACROS, F26585) (125 mg; 1.09 mMol) are suspended in NMP (0.5 mL) and stirred at 1400C for 10 min at 300 W in an Emry Optimizer (microwave oven from Personal Chemistry AB, Uppsala, Sweden). The reaction mixture is treated with water (2 mL) and extracted with EtOAc (2 x 10 mL). The combined organic layers are washed with a saturated NaHCO3 solution, water, then brine, and then dried (Na2SO4), and concentrated under reduced pressure. Purification is done by chromatography on a 4 g Redisep Sg-100 column (Teledyne ISCO, Inc., Lincoln, Nebraska, USA) eluting with CH2CI2/CH3OH 95:5 (v/v)), to obtain the title compound as beige crystals: MS(ESI+):m/z= 369.1 (M+H)+; HPLC: tRet = 5.33 minutes (System 1).
 

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