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Chemical Structure| 1016167-99-9
Chemical Structure| 1016167-99-9
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Product Details of [ 1016167-99-9 ]

CAS No. :1016167-99-9 MDL No. :MFCD03093385
Formula : C11H22N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 214.30 Pubchem ID :-
Synonyms :

Safety of [ 1016167-99-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1016167-99-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1016167-99-9 ]
  • Downstream synthetic route of [ 1016167-99-9 ]

[ 1016167-99-9 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 142643-29-6 ]
  • [ 1016167-99-9 ]
YieldReaction ConditionsOperation in experiment
65%
Stage #1: With (-)-di-p-toluoyl-L-tartaric acid In methanolReflux; Resolution of racemate
Stage #2: With sodium carbonate In water at 0℃; Resolution of racemate
Example 4Synthesis of (3S)-N-(t-butoxycarbonyl)-3-aminomethyl-piperidine (compound 5); N-(t-butoxycarbonyl)-3-aminomethyl piperidine (10 g, 1eq, 47 mmol), (-)-O, O -Di-p-tolouyl- L-tartaric acid (15.52, 1eq, 47 mmol) and dry methanol (100 ml) were mixed and heated slowly to refluxing to just to get a uniform solution. The reaction mixture was cooled to room temperature and stirred at this temperature for 5-6 hours. White solid formed was filtered out and washed with minimum quantity of dry methanol. The crude solid was recrystallized from methanol. The compound was suspended in distilled water (25 ml) and cooed to 0 °C. 10percent solution of sodium carbonate solution (100 ml) was then added portion wise, until basic, with stirring for 10 min. The reaction mixture was extracted with ethyl acetate (5 x 50 ml). The organic layer was separated, dried and concentrated under reduced pressure to obtain the compound of formula 3.Yield: 3.28g, 65 percentL J D : + 11.03 (c = 0.10; Methanol)MP: 64-66 °CIR (Neat):3360, 2972, 1703, 1519, 1455, 1365, 1255, 1172 cm"1 H NMR (CDCI3, 300 MHz)δ 1.01 -1.21 (m, 2H, H-4); 1.39 (s, 9H, -0-C(CH3)3); 1.57-1.72 (m, 3H, H-3, H-5); 2.20-2.31 (m, 1 H, CHaNHBoc); 2.49-2.56 (m, 1 H, CHbNHBoc); 2.90-3.03 (m, 4H, H-2, H-4); 4.77(brs, 1 H, NH)13C NMR(CDCI3, 300 MHz)26.56, 29.03, 29.58, 38.44, 44.99, 47.46, 51.16, 79.73, 156.72FAB MS (m/z):215(M+1 f , 1 14
Reference: [1] Patent: WO2012/104866, 2012, A1, . Location in patent: Page/Page column 17-18
  • 2
  • [ 1026661-43-7 ]
  • [ 1016167-99-9 ]
Reference: [1] Patent: CN108409639, 2018, A,
[2] Patent: CN108409639, 2018, A,
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Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Addition of an Amine to a Conjugated Enone • Acyl Group Substitution • Alcohols Convert Acyl Chlorides into Esters • Alcoholysis of Anhydrides • Amide Hydrolysis • Amide Hydrolysis • Amides Can Be Converted into Aldehydes • Amine Synthesis from Nitriles • Amine Synthesis from Nitriles • Amines Convert Acyl Chlorides into Amides • Amines Convert Esters into Amides • Azide Reduction by LiAlH4 • Azide Reduction by LiAlH4 • Basicity of Amines • Bouveault-Blanc Reduction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Chichibabin Reaction • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Complex Metal Hydride Reductions • Convert Esters into Aldehydes Using a Milder Reducing Agent • Decarboxylation of 3-Ketoacids Yields Ketones • Deprotection of Cbz-Amino Acids • Diazotization Reaction • DIBAL Attack Nitriles to Give Ketones • Enamine Formation • Ester Cleavage • Ester Hydrolysis • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Grignard Reagents Transform Esters into Alcohols • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hofmann Elimination • Hofmann Rearrangement • Hydride Reductions • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Methylation of Ammonia • Methylation of Ammonia • Nitrosation of Amines • Peptide Bond Formation with DCC • Petasis Reaction • Preparation of Amines • Preparation of LDA • Reactions of Amines • Reactions with Organometallic Reagents • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reduction of an Ester to an Alcohol • Reduction of an Ester to an Aldehyde • Reductive Amination • Reductive Amination • Ring Opening of Azacyclopropanes • Ring Opening of Azacyclopropanes • Ring Opening of Oxacyclobutanes • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Strecker Synthesis • Synthesis of 2-Amino Nitriles • The Cycloaddition of Dienes to Alkenes Gives Cyclohexenes • Transesterification • Ugi Reaction
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