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Chemical Structure| 1017020-52-8 Chemical Structure| 1017020-52-8

Structure of 1017020-52-8

Chemical Structure| 1017020-52-8

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Product Details of [ 1017020-52-8 ]

CAS No. :1017020-52-8
Formula : C11H12BrNO2
M.W : 270.12
SMILES Code : O=C(NC1CC1)COC2=CC=CC(Br)=C2
MDL No. :MFCD09942775

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Application In Synthesis of [ 1017020-52-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1017020-52-8 ]

[ 1017020-52-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 591-20-8 ]
  • [ 19047-31-5 ]
  • [ 1017020-52-8 ]
YieldReaction ConditionsOperation in experiment
65% With potassium carbonate; In acetonitrile; at 80℃; for 16h; To a solution of 3-bromophenol (3.42 g, 19.76 mmol) and 2-chloro-N- cyclopropylacetamide (3.30 g, 24.70 mmol) in MeCN (100.00 mL) was added K2C03 (6.83 g, 49.40 mmol). The mixture was stirred at 80 C for 16 hours. TLC (Petroleum ether/Ethyl acetate = 3 : 1, Rf = 0.2) showed that a main new spot was formed. The reaction mixture was cooled to room temperature and quenched by addition water (100 mL). The resulting was extracted with EtOAc (2 chi 100 mL). The combined organic layers were washed with brine (2 x l OO mL), dried over Na2S04, filtered, and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate: from 20: 1 to 1 : 1) to provide the compound (4.40 g, 65%) as a yellow oil.
 

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