* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With methanol; potassium carbonate In water at 20℃; for 2 h;
A solution of J.ii (1 g, 3.76 mmol) and K2C03 (1.04 g, 7.52 mmol) in MeOH/H20 (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vaccum to give the title compound J.iii as white solid (760 mg, yield 86percent). LCMS (method B): [M+H]+ = 224, tR = 2.29 min
86%
With water; potassium carbonate In methanol at 20℃; for 2 h;
A solution of Intermediate A (1 g, 3.76 mmol) and K2C03 (1.04 g, 7.52 mmol) in MeOH/H20 (5 mL/3 ml.) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vaccum to give the title compound as white solid (760 mg, yield 86percent). LCMS (method N): [M+H]+ = 224, tR = 2.29 min.
86%
With water; potassium carbonate In methanol at 20℃; for 1 h;
A solution of Intermediate A (1 g, 3.76 mmol) and K2CO3 (1.04 g, 7.52 mmol) in MeOH/H2O (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vacuum to give the title compound as white solid (760 mg, yield 86percent). LCMS (method N): [M+H]+=224, tR=2.29 min.
86%
With potassium carbonate In methanol; water at 20℃; for 2 h;
A solution of J.ii (1 g, 3.76 mmol) and K2CO3 (1.04 g, 7.52 mmol) in MeOH/H2O (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vacuum to give the title compound J.iii as white solid (760 mg, yield 86percent). LCMS (method B): [M+H]+=224, tR=2.29 min.
With methanol; potassium carbonate; In water; at 20℃; for 2h;
A solution of J.ii (1 g, 3.76 mmol) and K2C03 (1.04 g, 7.52 mmol) in MeOH/H20 (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vaccum to give the title compound J.iii as white solid (760 mg, yield 86%). LCMS (method B): [M+H]+ = 224, tR = 2.29 min
86%
With water; potassium carbonate; In methanol; at 20℃; for 2h;
A solution of Intermediate A (1 g, 3.76 mmol) and K2C03 (1.04 g, 7.52 mmol) in MeOH/H20 (5 mL/3 ml.) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vaccum to give the title compound as white solid (760 mg, yield 86%). LCMS (method N): [M+H]+ = 224, tR = 2.29 min.
86%
With water; potassium carbonate; In methanol; at 20℃; for 1h;
A solution of Intermediate A (1 g, 3.76 mmol) and K2CO3 (1.04 g, 7.52 mmol) in MeOH/H2O (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vacuum to give the title compound as white solid (760 mg, yield 86%). LCMS (method N): [M+H]+=224, tR=2.29 min.
86%
With potassium carbonate; In methanol; water; at 20℃; for 2h;
A solution of J.ii (1 g, 3.76 mmol) and K2CO3 (1.04 g, 7.52 mmol) in MeOH/H2O (5 mL/3 mL) was stirred at rt for 2 hours. The reaction mixture was concentrated under reduced pressure to afford a crude solid which was further purified by washing with water, dried under vacuum to give the title compound J.iii as white solid (760 mg, yield 86%). LCMS (method B): [M+H]+=224, tR=2.29 min.
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