Structure of Glibenclamide
CAS No.: 10238-21-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor used in diabetes and obesity research. It inhibits P-glycoprotein, directly binds and blocks the SUR1 subunits of KATP, inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR), interferes with mitochondrial bioenergetics by altering membrane ion permeability, and can induce autophagy.
Synonyms: Glyburide
4.5
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CAS No. : | 10238-21-8 |
Formula : | C23H28ClN3O5S |
M.W : | 494.00 |
SMILES Code : | O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC |
Synonyms : |
Glyburide
|
MDL No. : | MFCD00056625 |
InChI Key : | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
Pubchem ID : | 3488 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H413 |
Precautionary Statements: | P264-P270-P273-P301+P312-P330 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
Mouse peritoneal macrophages | 50 µM | 6 hours | Inhibited LPS-induced NLRP3 inflammasome activation and reduced the secretion of IL-1β and IL-18 | Mediators Inflamm. 2022 Feb 11;2022:8457010. |
In Vivo:
Administration | Dosage | Frequency | Description | References |
C57BL/6 mice | LPS-induced acute lung injury model | Intraperitoneal injection | 40 μmol/kg | Once daily for 3 days | Alleviated LPS-induced lung injury and inhibited the NLRP3 inflammasome signaling pathway | Mediators Inflamm. 2022 Feb 11;2022:8457010. |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00347100 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | China ... More >> Sanofi-Aventis Beijing, China Less << |
NCT01706211 | Diabetes Mellitus Non Insulin ... More >>Dependent Oral Agent Therapy Less << | Phase 3 | Completed | - | Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan, 10002 Less << |
NCT00608179 | Type 2 Diabetes | Not Applicable | Completed | - | - |
NCT02607410 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Brazil ... More >> University of Sao Paulo General Hospital Sao Paulo, Brazil, 05403-000 Less << |
NCT02133118 | - | Completed | - | Netherlands ... More >> Isala Zwolle, Overijssel, Netherlands, 8000 AB Less << | |
NCT00379769 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00379769 | - | Completed | - | - | |
NCT00549874 | Type 2 Diabetes | Not Applicable | Completed | - | United States, Michigan ... More >> University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Ohio University of Toledo - Health Campus Toledo, Ohio, United States, 43606 Less << |
NCT01242215 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Chubu, Japan Chugoku, Japan Hokkaido, Japan Kansai, Japan Kantou, Japan Kyushu, Japan Touhoku, Japan Less << |
NCT01195259 | - | Completed | - | - | |
NCT01319734 | Type 2 Diabetes Mellitus | Phase 1 | Unknown | - | Sudan ... More >> Jaber abo aliz Recruiting Khartoum, Sudan, 1111 Contact: Khaled H Bakheet, MD,PhD +249912957764 khalid2_3456@yahoo.com Principal Investigator: Hamdan Z Hamdan, MBBS,MSc Less << |
NCT00251940 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... More >>gram has been terminated) Less << | - | - |
NCT00286468 | Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT03029702 | Gestational Diabetes ... More >> Diabetes, Gestational Pregnancy in Diabetes Less << | Phase 4 | Recruiting | March 30, 2021 | United States, Pennsylvania ... More >> Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Maisa Feghali, MD 412-641-4874 feghalim@upmc.edu Principal Investigator: Maisa Feghali, MD Less << |
NCT01107717 | Diabetes | Not Applicable | Recruiting | December 2024 | United States, Texas ... More >> Texas Diabetes Institute Recruiting San Antonio, Texas, United States, 78229-3900 Contact: Muhammad Abdul-Ghani, MD, PhD 210-567-2391 ABDULGHANI@UTHSCSA.EDU Contact: Curtiss Puckett, PA (210) 358 7200 Curtiss.Puckett@uhs-sa.com Principal Investigator: Ralph DeFronzo, MD Less << |
NCT01028846 | Type 2 Diabetes | Phase 2 | Recruiting | December 2022 | United States, New York ... More >> Albert Einstein College of Medicine of Yeshiva University Recruiting Bronx, New York, United States, 10461 Principal Investigator: Meredith Hawkins, MD Less << |
NCT00232583 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | United States, Texas ... More >> University of Texas Southwestern Dallas, Texas, United States, 75390 Less << |
NCT00232583 | - | Completed | - | - | |
NCT01934816 | Healthy Subjects | Not Applicable | Terminated(Technical Issues wi... More >>th intervention) Less << | - | United Kingdom ... More >> Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom, EX25DW Less << |
NCT00472875 | Type 1 Diabetes Mellitus | PHASE4 | UNKNOWN | - | King's College Hospital NHS Fo... More >>undation Trust, London, SE5 9RS, United Kingdom Less << |
NCT00371306 | Gestational Diabetes ... More >> Type 2 Diabetes Pregnancy Less << | Not Applicable | Unknown | September 2008 | United States, Tennessee ... More >> Regional Obstetrical Consultants Recruiting Chattanooga, Tennessee, United States, 37403 Less << |
NCT00162175 | Metabolics Diabetes Nos | Phase 3 | Completed | - | - |
NCT00286468 | - | Completed | - | - | |
NCT00313313 | Diabetes | Phase 3 | Completed | - | - |
NCT00300105 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... More >>gram has been terminated) Less << | - | - |
NCT00035542 | Diabetes Mellitus, Non-Insulin... More >>-Dependent Less << | Phase 3 | Completed | - | - |
NCT00700856 | Type 2 Diabetes Mellitus ... More >> Cardiovascular Disease Less << | Phase 4 | Unknown | December 2018 | - |
NCT02624830 | Permanent Neonatal Diabetes Me... More >>llitus Less << | Phase 4 | Unknown | February 2016 | Norway ... More >> Haukeland University Hospital Bergen, Norway, 5021 Less << |
NCT01698931 | Diabetes Diab... More >>etes Mellitus, Type 2 Less << | Phase 4 | Completed | - | Italy ... More >> Novo Nordisk Investigational Site Padova, Italy, 35137 Less << |
NCT02624817 | Permanent Neonatal Diabetes Me... More >>llitus Less << | Phase 4 | Completed | - | Norway ... More >> Haukeland University Hospital Bergen, Norway, 5021 Less << |
NCT01029795 | Diabetes Mellitus, Type 2 | Phase 2 | Terminated(Terminated due to n... More >>onclinical safety findings) Less << | - | Australia, South Australia ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Elizabeth Vale, South Australia, Australia, 5112 Australia, Victoria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. East Ringwood, Victoria, Australia, 3135 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Heidelberg, Victoria, Australia, 3081 Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Vienna, Austria, 1090 Czech Republic For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Holesov, Czech Republic, 769 01 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Prague, Czech Republic, 140 59 Germany For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Mainz, Germany, 55116 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Neuss, Germany, D-41460 Israel For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Jerusalem, Israel, 91120 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nahariya, Israel, 22100 Russian Federation For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Rostov-On-Don, Russian Federation, 344022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Saint Petersburg, Russian Federation, 191126 Spain For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Barcelona, Spain, 08022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Cordoba, Spain, 14004 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dos Hermanas, Spain, 41014 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Teruel, Spain, 44002 Less << |
NCT01029795 | - | Terminated(Terminated due to n... More >>onclinical safety findings) Less << | - | - | |
NCT03527537 | Gestational Diabetes | Phase 4 | Not yet recruiting | June 1, 2028 | United States, Wisconsin ... More >> Medical College of Wisconsin Not yet recruiting Milwaukee, Wisconsin, United States, 53226 Less << |
NCT00696982 | Diabetes Mellitus ... More >> Arterial Stiffness Less << | Not Applicable | Unknown | June 2009 | Israel ... More >> Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel Recruiting Zrifin, Israel, 70300 Contact: Shlomit Koren, MD 972-546-888=385 shlomitks@gmail.com Contact: Shai Efrati, MD 972-577-346-364 efratishai@013.net Principal Investigator: Shlomit Koren, MD Less << |
NCT00393718 | - | Completed | - | - | |
NCT01242137 | - | Unknown | - | Israel ... More >> Assaf Harofe Medical Center Recruiting Beer Yakov, Israel Contact: Amit Tirosh, Dr 972-52-4748989 tiroshamit@gmail.com Principal Investigator: Amit Tirosh, Dr Less << | |
NCT00035568 | Diabetes Mellitus, Non-Insulin... More >>-Dependent Less << | Phase 4 | Completed | - | United States, Arkansas ... More >> Local Institution Little Rock, Arkansas, United States United States, California Local Institution Los Angeles, California, United States United States, Illinois Local Institution Chicago, Illinois, United States United States, Indiana Local Institution Indianapolis, Indiana, United States United States, New York Local Institution Brooklyn, New York, United States Local Institution Rochester, New York, United States United States, Pennsylvania Local Institution Pittsburgh, Pennsylvania, United States United States, Texas Local Institution Dallas, Texas, United States Local Institution San Antonio, Texas, United States Less << |
NCT01605773 | Diabetes Diab... More >>etes Mellitus, Type 2 Less << | Phase 4 | Completed | - | United States, Texas ... More >> Novo Nordisk Investigational Site Houston, Texas, United States, 77030 Less << |
NCT00313313 | - | Completed | - | - | |
NCT00194896 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | United States, Washington ... More >> DVA Puget Sound Health Care System Seattle, Washington, United States, 98108 Less << |
NCT00194896 | - | Completed | - | - | |
NCT00935363 | Healthy | Phase 1 | Withdrawn | April 2010 | - |
NCT00333723 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT00393718 | Diabetes Diab... More >>etes Mellitus, Type 2 Less << | Phase 3 | Completed | - | Japan ... More >> Novo Nordisk Investigational Site Tokyo, Japan, 1000005 Less << |
NCT01145534 | Diabetes | Phase 1 Phase 2 | Completed | - | Brazil ... More >> Centro de Especialidades Odontologicas Patos, Paraiba, Brazil, 58700-020 Less << |
NCT02255006 | Healthy | Not Applicable | Unknown | December 2014 | Korea, Republic of ... More >> Kyung Hee University Medical Center Recruiting Seoul, Korea, Republic of, 130-701 Contact: Weon Kim, Professor 82-2-958-8176 mylovekw@hanmail.net Less << |
NCT00770835 | Diabetes Mellitus | Phase 4 | Completed | - | Italy ... More >> Padova, Italy Pisa, Italy Less << |
NCT02091336 | Gestational Diabetes | Phase 4 | Unknown | December 2016 | Brazil ... More >> Hospital de Clínicas de Porto Alegre Recruiting Porto Alegre, RS, Brazil, 90035-903 Less << |
NCT00541437 | - | Completed | - | Taiwan ... More >> National Taiwan university hospital Taipei, Taiwan Less << | |
NCT02128022 | Angina Pectoris | Phase 1 | Completed | - | United Kingdom ... More >> Papworth Hospital Cambridge, Cambridgeshire, United Kingdom, CB23 3RE Less << |
NCT00238472 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT01563120 | Gestational Diabetes Mellitus | Phase 4 | Completed | - | Israel ... More >> Dep. OB/GYN, Emek Medical Center Afula, Israel Less << |
NCT00123643 | - | Completed | - | - | |
NCT01215331 | Gestational Diabetes Mellitus | Phase 3 | Completed | - | Canada, Quebec ... More >> Centre de recherche clinique du CHUS Sherbrooke, Quebec, Canada, J1H 5N4 Less << |
NCT00123643 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United States, Minnesota ... More >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Less << |
NCT01132703 | Traumatic Brain Injury ... More >> Stroke Less << | Phase 1 | Completed | - | United States, Michigan ... More >> Jasper Clinic Kalamazoo, Michigan, United States, 49007 Less << |
NCT00521742 | Diabetes Mellitus | Phase 3 | Completed | - | - |
NCT00388986 | Diabetes Mellitus Type 2 | Phase 1 | Completed | - | United States, California ... More >> Cypress, California, United States, 90630 United States, Hawaii Honolulu, Hawaii, United States, 96813 United States, New York Buffalo, New York, United States, NY 14215 United States, Texas San Antonio, Texas, United States, 78229 Less << |
NCT01998113 | - | Completed | - | Spain ... More >> Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Less << | |
NCT01947699 | Gestational Diabetes | Phase 4 | Withdrawn(PI decided to withdr... More >>awal study before recruitment started) Less << | - | United States, Pennsylvania ... More >> Magee Womens Hospital of UPMC Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT02864953 | Brain Edema S... More >>troke, Acute Less << | Phase 3 | Recruiting | December 30, 2021 | - |
NCT02201602 | Diabetes | Phase 4 | Completed | - | Singapore ... More >> Khoo Teck Puat Hospital Singapore, Singapore, 768828 Less << |
NCT01329016 | Gestational Diabetes Mellitus | Phase 1 Phase 2 | Unknown | June 2015 | United States, Indiana ... More >> Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555 United States, Washington University of Washington Seattle, Washington, United States, 98195 Less << |
NCT00494312 | Diabetes Mellitus ... More >> Liver Less << | Phase 4 | Completed | - | - |
NCT00521820 | Diabetes Mellitus | Phase 3 | Terminated(Higher incidence of... More >> hospitalization for congestive heart failure in pioglitazone-treated subjects compared to glyburide treated subjects.) Less << | - | - |
NCT02375828 | Neonatal Diabetes Secondary to... More >> Mutation in the Potassium Channel Less << | PHASE3 | COMPLETED | 2019-07-22 | H?pital Universitaire Necker E... More >>nfants Malades, Paris, 7501, France Less << |
NCT00160485 | Gestational Diabetes | Phase 4 | Withdrawn(Active Duty principl... More >>e investigator currently deployed) Less << | June 2010 | United States, Hawaii ... More >> Tripler Army Medical Center Honolulu, Hawaii, United States, 97859 Less << |
NCT00744965 | Mild Gestational Diabetes | Phase 4 | Completed | - | United States, Texas ... More >> Parkland Memorial Hospital Dallas, Texas, United States, 75235 Less << |
NCT00836472 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less << |
NCT00267683 | Diabetes Diab... More >>etes Mellitus, Type 2 Less << | Phase 3 | Terminated(This trial was term... More >>inated due to low recruitment) Less << | - | - |
NCT01731431 | Diabetes Gest... More >>ational Less << | Phase 3 | Completed | - | France ... More >> Marie-Victoire Senat Paris, France, 94270 Less << |
NCT03089333 | Hypertension ... More >>Diabetes Mellitus, Type 2 Blood Pressure Obesity Cardiac Hypertrophy Microalbuminuria Vascular Stiffness Less << | Phase 4 | Completed | - | Brazil ... More >> University of Campinas (UNICAMP) Campinas, São Paulo, Brazil, 13083970 Less << |
NCT00835991 | - | Completed | - | - | |
NCT00759720 | Diabetes Mellitus | Phase 3 | Terminated(Potential hepatic s... More >>afety signal) Less << | - | - |
NCT00610038 | Diabetes Mellitus | Phase 2 | Completed | - | France ... More >> Necker Hospital - Endocrinology Gynecology Pediatric unit Paris, France, 75015 Less << |
NCT00965991 | Gestational Diabetes | Not Applicable | Completed | - | United States, New Mexico ... More >> University of New Mexico Diabetes in Pregnancy Clinic Albuquerque, New Mexico, United States, 87131 Less << |
NCT00836472 | - | Completed | - | - | |
NCT00835991 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less << |
NCT00865241 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less << |
NCT00865436 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less << |
NCT03078725 | Gestational Diabetes Mellitus,... More >> Class A2 Less << | Phase 4 | Withdrawn(Research was competi... More >>ng with other projects in the department, and no patients were recruited.) Less << | May 10, 2018 | - |
NCT00451620 | Type 2 Diabetes | Phase 2 | Completed | - | Canada, British Columbia ... More >> University of British Columbia Vancouver, British Columbia, Canada Less << |
NCT00255541 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... More >>gram has been terminated) Less << | - | - |
NCT00864734 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less << |
NCT00734669 | Type 2 Diabetes | COMPLETED | 2025-10-16 | - | |
NCT02460874 | Cerebral Edema ... More >> Brain Metastases Less << | Phase 1 Phase 2 | Recruiting | October 2020 | United States, Alabama ... More >> University of Alabama at Birmingham (UAB) Department of Radiation Oncology Recruiting Birmingham, Alabama, United States, 35249 Contact: Kristin Webb kkwebb@uabmc.edu Contact: Valerie Powell vpowell@uabmc.edu Principal Investigator: Drexell H Boggs, MD Less << |
NCT00279045 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01268683 | Ischemic Stroke | Phase 1 Phase 2 | Completed | - | United States, Illinois ... More >> Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Maryland University of Maryland Medical Center Baltimore, Maryland, United States United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT01268683 | - | Completed | - | - | |
NCT02080377 | Pregnancy Ges... More >>tational Diabetes Less << | Phase 3 | Completed | - | United Kingdom ... More >> Princess Royal Infirmary Glasgow, Lanarkshire, United Kingdom, G31 2ER Simpson Centre for Reproductive Health, Royal Infirmary Hospital, Edinburgh Edinburgh, Lothian, United Kingdom, EH16 4SA Western General Hospital Edinburgh, Lothian, United Kingdom, EH4 2XU St Johns Hospital Livingston, West Lothian, United Kingdom Queen Elizabeth Hospital Glasgow, United Kingdom Less << |
NCT01794182 | Ischemic Stroke ... More >> Malignant Edema Less << | Phase 2 | Unknown | April 2016 | United States, Arizona ... More >> University of Arizona Medical Center Tucson, Arizona, United States, 85719 United States, California Stanford University Medical Center Stanford, California, United States, 94305 United States, Connecticut Yale University School of Medicine New Haven, Connecticut, United States, 06510 United States, Florida University of Florida, Jacksonville Jacksonville, Florida, United States, 32209 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 United States, Kentucky University of Louisville Hospital Louisville, Kentucky, United States, 40202 United States, Maine Maine Medical Center Scarborough, Maine, United States, 04074 United States, Maryland University of Maryland School of Medicine Baltimore, Maryland, United States, 21201 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 UMASS Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 Ohio State University Wexner Medical Center Columbus, Ohio, United States, 43210 United States, Oregon Oregon Health & Science University Hospital Portland, Oregon, United States, 97239 United States, Pennsylvania Abington Memorial Hospital Abington, Pennsylvania, United States, 19001 UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Utah University of Utah Healthcare Salt Lake City, Utah, United States, 84132 Less << |
NCT01454154 | Traumatic Brain Injury | Phase 2 | Unknown | September 2015 | United States, California ... More >> University of California, San Diego San Diego, California, United States, 92103 United States, Maryland University of Maryland Medical Center, Shock Trauma Center Baltimore, Maryland, United States, 21201 United States, Pennsylvania UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, Virginia VCU Medical Center Richmond, Virginia, United States, 23298 Less << |
NCT00515801 | Diabetes Mellitus, Type 1 | Phase 2 Phase 3 | Completed | - | Switzerland ... More >> University Hospital Basel Basel, Switzerland, 4031 Less << |
NCT02815787 | Type 2 Diabetes | Phase 1 | Completed | - | China, Shandong ... More >> Qilu Hospital of Shandong University Jinan, Shandong, China, 250012 Less << |
NCT01716338 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... More >> Washington University in St. Louis Clinical Research Unit (CRU) St. Louis, Missouri, United States, 63110 Less << |
NCT02183428 | Healthy | Phase 1 | Completed | - | - |
NCT01822548 | Type 2 Diabetes | Phase 3 | Completed | - | Italy ... More >> Azienda Opedaliera-Universitaria Parma, Italy, 43126 Azienda Ospedaliera-Universitaria Parma, Italy, 43126 Less << |
NCT02919345 | Diabetes Mellitus, Type 2 ... More >> Coronary Artery Disease Carotid Artery Diseases Less << | Phase 4 | Unknown | October 2017 | Brazil ... More >> State University of Campinas Campinas, Sao Paulo, Brazil, 13083-887 Less << |
NCT02318693 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | - |
NCT01822548 | - | Completed | - | - | |
NCT01045590 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Korea, Republic of ... More >> GSK Investigational Site Seoul, Korea, Republic of, 110-744 GSK Investigational Site Seoul, Korea, Republic of, 120-752 GSK Investigational Site Seoul, Korea, Republic of, 135-710 GSK Investigational Site Seoul, Korea, Republic of, 137-701 Less << |
NCT00417729 | Diabetes Mellitus | Phase 4 | Completed | - | Taiwan ... More >> Taichung Veterans General Hospital Taichung, Taiwan Less << |
NCT01733108 | Healthy | Phase 1 | Completed | - | - |
NCT01867502 | Diabetes Mellitus, Type 2 ... More >> Hypoglycemic Agents Diabetic Blood Glucose Monitoring Exercise Less << | Phase 4 | Unknown | August 2015 | Brazil ... More >> Hospital de Clínicas de Porto Alegre Porto Alegre Recruiting Porto Alegre, Rio Grande do Sul, Brazil, 90035-903 Contact: Aline Fofonka, MSc 55-5192339191 alinefofonka@hotmail.com Principal Investigator: Beatriz D Schaan, PhD Less << |
NCT02726490 | Gestational Diabetes | Not Applicable | Terminated(Lack of Recruitment... More >>) Less << | - | United States, Texas ... More >> TTUHSC El Paso El Paso, Texas, United States, 79905 Less << |
NCT03569540 | Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << | Phase 4 | Recruiting | December 1, 2019 | Brazil ... More >> Hospital das Clínicas da Faculdade de Medicina de São Paulo Recruiting São Paulo, SP, Brazil, 05403000 Contact: Eberval Figueiredo, MD PHD +551126617152 ebgadelha@yahoo.com Principal Investigator: Bruno B Costa, MD Sub-Investigator: Isabella Windlin, MD Sub-Investigator: Nicollas R Nunes, MD Sub-Investigator: Vitor N Yamaki, MD Sub-Investigator: Edwin Koterba, MD, PHD Less << |
NCT02318693 | - | Completed | - | - | |
NCT02524379 | Acute Spinal Cord Injury | PHASE1|PHASE2 | TERMINATED | 2021-02-08 | The Ohio State University, Col... More >>umbus, Ohio, 43210, United States Less << |
NCT03741530 | Intracerebral Hemorrhage | Not Applicable | Enrolling by invitation | October 31, 2020 | China, Shaanxi ... More >> Xijing Hospital Xi'an, Shaanxi, China, 710032 Less << |
NCT03284463 | Acute Stroke | Phase 4 | Recruiting | September 30, 2021 | China, Guangdong ... More >> Huadu District People's Hospital of Guangzhou Not yet recruiting Guangzhou, Guangdong, China, 510515 Contact: Xiangmin Liu, M.D. Nanfang Hospital of Southern Medical University Recruiting Guangzhou, Guangdong, China Contact: Kaibin Huang hkb@smu.edu.cn Principal Investigator: Suyue Pan, M.D., Ph.D. Heyuan People's Hospital Recruiting Heyuan, Guangdong, China Contact: Yunqiang Huang, M.D. +8613750225240 13750225240@126.com Maoming People's Hospital Recruiting Maoming, Guangdong, China Contact: Hao Li, M.D. 185416656@qq.com Principal Investigator: Zhi Yan, M.D. Maoming Traditional Chinese Medical Hospital Recruiting Maoming, Guangdong, China Contact: Dongrun Yan, M.D. 1792191@qq.com Principal Investigator: Wenguo Huang, M.D. China, Hainan Hainan Provincial Hospital of Traditional Chinese Medicine Recruiting Haikou, Hainan, China, 570100 Contact: Guangfeng Zhao, M.D. +8613700410380 408195770@qq.com Principal Investigator: Guohu Weng, M.D. China, Jiangsu The First Affiliated Hospital of Wenzhou Medical University Recruiting Wenzhou, Jiangsu, China, 325000 Contact: Saijun Zhou, M.D. +8613857746659 2498093074@qq.com Principal Investigator: Xu Zhang, M.D. Less << |
NCT02830048 | Diabetes Mellitus, Type 2 | PHASE2 | COMPLETED | 2017-03-09 | Clinical Research Unit, OCDEM,... More >> Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, United Kingdom Less << |
NCT01456650 | Type 2 Diabetes | PHASE4 | COMPLETED | 2025-12-12 | Instituto Nacional de Ciencias... More >> Medicas y Nutricion, Mexico City, DF, 14000, Mexico Less << |
NCT02145611 | Type 2 Diabetes Mellitus ... More >> Hypertension Endothelial Dysfunction Less << | Phase 4 | Completed | - | Brazil ... More >> Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, São Paulo, Brazil, 15090-000 Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.12mL 2.02mL 1.01mL |
20.24mL 4.05mL 2.02mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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