Home Cart Sign in  
Chemical Structure| 10238-21-8 Chemical Structure| 10238-21-8

Structure of Glibenclamide
CAS No.: 10238-21-8

Chemical Structure| 10238-21-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor used in diabetes and obesity research. It inhibits P-glycoprotein, directly binds and blocks the SUR1 subunits of KATP, inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR), interferes with mitochondrial bioenergetics by altering membrane ion permeability, and can induce autophagy.

Synonyms: Glyburide

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Glibenclamide

CAS No. :10238-21-8
Formula : C23H28ClN3O5S
M.W : 494.00
SMILES Code : O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC
Synonyms :
Glyburide
MDL No. :MFCD00056625
InChI Key :ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Pubchem ID :3488

Safety of Glibenclamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H413
Precautionary Statements:P264-P270-P273-P301+P312-P330

Isoform Comparison

Biological Activity

Target
  • Potassium Channel

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse peritoneal macrophages 50 µM 6 hours Inhibited LPS-induced NLRP3 inflammasome activation and reduced the secretion of IL-1β and IL-18 Mediators Inflamm. 2022 Feb 11;2022:8457010.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice LPS-induced acute lung injury model Intraperitoneal injection 40 μmol/kg Once daily for 3 days Alleviated LPS-induced lung injury and inhibited the NLRP3 inflammasome signaling pathway Mediators Inflamm. 2022 Feb 11;2022:8457010.

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00347100 Diabetes Mellitus, Type 2 Phase 4 Completed - China ... More >> Sanofi-Aventis Beijing, China Less <<
NCT01706211 Diabetes Mellitus Non Insulin ... More >>Dependent Oral Agent Therapy Less << Phase 3 Completed - Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan, 10002 Less <<
NCT00608179 Type 2 Diabetes Not Applicable Completed - -
NCT02607410 Type 2 Diabetes Mellitus Phase 4 Completed - Brazil ... More >> University of Sao Paulo General Hospital Sao Paulo, Brazil, 05403-000 Less <<
NCT02133118 - Completed - Netherlands ... More >> Isala Zwolle, Overijssel, Netherlands, 8000 AB Less <<
NCT00379769 Diabetes Mellitus, Type 2 Phase 3 Completed - -
NCT00379769 - Completed - -
NCT00549874 Type 2 Diabetes Not Applicable Completed - United States, Michigan ... More >> University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Ohio University of Toledo - Health Campus Toledo, Ohio, United States, 43606 Less <<
NCT01242215 Type 2 Diabetes Mellitus Phase 3 Completed - Japan ... More >> Chubu, Japan Chugoku, Japan Hokkaido, Japan Kansai, Japan Kantou, Japan Kyushu, Japan Touhoku, Japan Less <<
NCT01195259 - Completed - -
NCT01319734 Type 2 Diabetes Mellitus Phase 1 Unknown - Sudan ... More >> Jaber abo aliz Recruiting Khartoum, Sudan, 1111 Contact: Khaled H Bakheet, MD,PhD    +249912957764    khalid2_3456@yahoo.com    Principal Investigator: Hamdan Z Hamdan, MBBS,MSc Less <<
NCT00251940 Type 2 Diabetes Phase 3 Terminated(The development pro... More >>gram has been terminated) Less << - -
NCT00286468 Diabetes Mellitus Phase 3 Completed - -
NCT03029702 Gestational Diabetes ... More >> Diabetes, Gestational Pregnancy in Diabetes Less << Phase 4 Recruiting March 30, 2021 United States, Pennsylvania ... More >> Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Maisa Feghali, MD    412-641-4874    feghalim@upmc.edu    Principal Investigator: Maisa Feghali, MD Less <<
NCT01107717 Diabetes Not Applicable Recruiting December 2024 United States, Texas ... More >> Texas Diabetes Institute Recruiting San Antonio, Texas, United States, 78229-3900 Contact: Muhammad Abdul-Ghani, MD, PhD    210-567-2391    ABDULGHANI@UTHSCSA.EDU    Contact: Curtiss Puckett, PA    (210) 358 7200    Curtiss.Puckett@uhs-sa.com    Principal Investigator: Ralph DeFronzo, MD Less <<
NCT01028846 Type 2 Diabetes Phase 2 Recruiting December 2022 United States, New York ... More >> Albert Einstein College of Medicine of Yeshiva University Recruiting Bronx, New York, United States, 10461 Principal Investigator: Meredith Hawkins, MD Less <<
NCT00232583 Type 2 Diabetes Mellitus Not Applicable Completed - United States, Texas ... More >> University of Texas Southwestern Dallas, Texas, United States, 75390 Less <<
NCT00232583 - Completed - -
NCT01934816 Healthy Subjects Not Applicable Terminated(Technical Issues wi... More >>th intervention) Less << - United Kingdom ... More >> Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom, EX25DW Less <<
NCT00472875 Type 1 Diabetes Mellitus PHASE4 UNKNOWN - King's College Hospital NHS Fo... More >>undation Trust, London, SE5 9RS, United Kingdom Less <<
NCT00371306 Gestational Diabetes ... More >> Type 2 Diabetes Pregnancy Less << Not Applicable Unknown September 2008 United States, Tennessee ... More >> Regional Obstetrical Consultants Recruiting Chattanooga, Tennessee, United States, 37403 Less <<
NCT00162175 Metabolics Diabetes Nos Phase 3 Completed - -
NCT00286468 - Completed - -
NCT00313313 Diabetes Phase 3 Completed - -
NCT00300105 Type 2 Diabetes Phase 3 Terminated(The development pro... More >>gram has been terminated) Less << - -
NCT00035542 Diabetes Mellitus, Non-Insulin... More >>-Dependent Less << Phase 3 Completed - -
NCT00700856 Type 2 Diabetes Mellitus ... More >> Cardiovascular Disease Less << Phase 4 Unknown December 2018 -
NCT02624830 Permanent Neonatal Diabetes Me... More >>llitus Less << Phase 4 Unknown February 2016 Norway ... More >> Haukeland University Hospital Bergen, Norway, 5021 Less <<
NCT01698931 Diabetes Diab... More >>etes Mellitus, Type 2 Less << Phase 4 Completed - Italy ... More >> Novo Nordisk Investigational Site Padova, Italy, 35137 Less <<
NCT02624817 Permanent Neonatal Diabetes Me... More >>llitus Less << Phase 4 Completed - Norway ... More >> Haukeland University Hospital Bergen, Norway, 5021 Less <<
NCT01029795 Diabetes Mellitus, Type 2 Phase 2 Terminated(Terminated due to n... More >>onclinical safety findings) Less << - Australia, South Australia ... More >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Elizabeth Vale, South Australia, Australia, 5112 Australia, Victoria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. East Ringwood, Victoria, Australia, 3135 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Heidelberg, Victoria, Australia, 3081 Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Vienna, Austria, 1090 Czech Republic For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Holesov, Czech Republic, 769 01 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Prague, Czech Republic, 140 59 Germany For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Mainz, Germany, 55116 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Neuss, Germany, D-41460 Israel For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Jerusalem, Israel, 91120 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nahariya, Israel, 22100 Russian Federation For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Rostov-On-Don, Russian Federation, 344022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Saint Petersburg, Russian Federation, 191126 Spain For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Barcelona, Spain, 08022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Cordoba, Spain, 14004 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dos Hermanas, Spain, 41014 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Teruel, Spain, 44002 Less <<
NCT01029795 - Terminated(Terminated due to n... More >>onclinical safety findings) Less << - -
NCT03527537 Gestational Diabetes Phase 4 Not yet recruiting June 1, 2028 United States, Wisconsin ... More >> Medical College of Wisconsin Not yet recruiting Milwaukee, Wisconsin, United States, 53226 Less <<
NCT00696982 Diabetes Mellitus ... More >> Arterial Stiffness Less << Not Applicable Unknown June 2009 Israel ... More >> Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel Recruiting Zrifin, Israel, 70300 Contact: Shlomit Koren, MD    972-546-888=385    shlomitks@gmail.com    Contact: Shai Efrati, MD    972-577-346-364    efratishai@013.net    Principal Investigator: Shlomit Koren, MD Less <<
NCT00393718 - Completed - -
NCT01242137 - Unknown - Israel ... More >> Assaf Harofe Medical Center Recruiting Beer Yakov, Israel Contact: Amit Tirosh, Dr    972-52-4748989    tiroshamit@gmail.com    Principal Investigator: Amit Tirosh, Dr Less <<
NCT00035568 Diabetes Mellitus, Non-Insulin... More >>-Dependent Less << Phase 4 Completed - United States, Arkansas ... More >> Local Institution Little Rock, Arkansas, United States United States, California Local Institution Los Angeles, California, United States United States, Illinois Local Institution Chicago, Illinois, United States United States, Indiana Local Institution Indianapolis, Indiana, United States United States, New York Local Institution Brooklyn, New York, United States Local Institution Rochester, New York, United States United States, Pennsylvania Local Institution Pittsburgh, Pennsylvania, United States United States, Texas Local Institution Dallas, Texas, United States Local Institution San Antonio, Texas, United States Less <<
NCT01605773 Diabetes Diab... More >>etes Mellitus, Type 2 Less << Phase 4 Completed - United States, Texas ... More >> Novo Nordisk Investigational Site Houston, Texas, United States, 77030 Less <<
NCT00313313 - Completed - -
NCT00194896 Type 2 Diabetes Mellitus Not Applicable Completed - United States, Washington ... More >> DVA Puget Sound Health Care System Seattle, Washington, United States, 98108 Less <<
NCT00194896 - Completed - -
NCT00935363 Healthy Phase 1 Withdrawn April 2010 -
NCT00333723 Diabetes Mellitus, Type 2 Phase 4 Completed - -
NCT00393718 Diabetes Diab... More >>etes Mellitus, Type 2 Less << Phase 3 Completed - Japan ... More >> Novo Nordisk Investigational Site Tokyo, Japan, 1000005 Less <<
NCT01145534 Diabetes Phase 1 Phase 2 Completed - Brazil ... More >> Centro de Especialidades Odontologicas Patos, Paraiba, Brazil, 58700-020 Less <<
NCT02255006 Healthy Not Applicable Unknown December 2014 Korea, Republic of ... More >> Kyung Hee University Medical Center Recruiting Seoul, Korea, Republic of, 130-701 Contact: Weon Kim, Professor    82-2-958-8176    mylovekw@hanmail.net Less <<
NCT00770835 Diabetes Mellitus Phase 4 Completed - Italy ... More >> Padova, Italy Pisa, Italy Less <<
NCT02091336 Gestational Diabetes Phase 4 Unknown December 2016 Brazil ... More >> Hospital de Clínicas de Porto Alegre Recruiting Porto Alegre, RS, Brazil, 90035-903 Less <<
NCT00541437 - Completed - Taiwan ... More >> National Taiwan university hospital Taipei, Taiwan Less <<
NCT02128022 Angina Pectoris Phase 1 Completed - United Kingdom ... More >> Papworth Hospital Cambridge, Cambridgeshire, United Kingdom, CB23 3RE Less <<
NCT00238472 Diabetes Mellitus, Type 2 Phase 4 Completed - -
NCT01563120 Gestational Diabetes Mellitus Phase 4 Completed - Israel ... More >> Dep. OB/GYN, Emek Medical Center Afula, Israel Less <<
NCT00123643 - Completed - -
NCT01215331 Gestational Diabetes Mellitus Phase 3 Completed - Canada, Quebec ... More >> Centre de recherche clinique du CHUS Sherbrooke, Quebec, Canada, J1H 5N4 Less <<
NCT00123643 Type 2 Diabetes Mellitus Phase 4 Completed - United States, Minnesota ... More >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Less <<
NCT01132703 Traumatic Brain Injury ... More >> Stroke Less << Phase 1 Completed - United States, Michigan ... More >> Jasper Clinic Kalamazoo, Michigan, United States, 49007 Less <<
NCT00521742 Diabetes Mellitus Phase 3 Completed - -
NCT00388986 Diabetes Mellitus Type 2 Phase 1 Completed - United States, California ... More >> Cypress, California, United States, 90630 United States, Hawaii Honolulu, Hawaii, United States, 96813 United States, New York Buffalo, New York, United States, NY 14215 United States, Texas San Antonio, Texas, United States, 78229 Less <<
NCT01998113 - Completed - Spain ... More >> Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Less <<
NCT01947699 Gestational Diabetes Phase 4 Withdrawn(PI decided to withdr... More >>awal study before recruitment started) Less << - United States, Pennsylvania ... More >> Magee Womens Hospital of UPMC Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT02864953 Brain Edema S... More >>troke, Acute Less << Phase 3 Recruiting December 30, 2021 -
NCT02201602 Diabetes Phase 4 Completed - Singapore ... More >> Khoo Teck Puat Hospital Singapore, Singapore, 768828 Less <<
NCT01329016 Gestational Diabetes Mellitus Phase 1 Phase 2 Unknown June 2015 United States, Indiana ... More >> Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555 United States, Washington University of Washington Seattle, Washington, United States, 98195 Less <<
NCT00494312 Diabetes Mellitus ... More >> Liver Less << Phase 4 Completed - -
NCT00521820 Diabetes Mellitus Phase 3 Terminated(Higher incidence of... More >> hospitalization for congestive heart failure in pioglitazone-treated subjects compared to glyburide treated subjects.) Less << - -
NCT02375828 Neonatal Diabetes Secondary to... More >> Mutation in the Potassium Channel Less << PHASE3 COMPLETED 2019-07-22 H?pital Universitaire Necker E... More >>nfants Malades, Paris, 7501, France Less <<
NCT00160485 Gestational Diabetes Phase 4 Withdrawn(Active Duty principl... More >>e investigator currently deployed) Less << June 2010 United States, Hawaii ... More >> Tripler Army Medical Center Honolulu, Hawaii, United States, 97859 Less <<
NCT00744965 Mild Gestational Diabetes Phase 4 Completed - United States, Texas ... More >> Parkland Memorial Hospital Dallas, Texas, United States, 75235 Less <<
NCT00836472 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less <<
NCT00267683 Diabetes Diab... More >>etes Mellitus, Type 2 Less << Phase 3 Terminated(This trial was term... More >>inated due to low recruitment) Less << - -
NCT01731431 Diabetes Gest... More >>ational Less << Phase 3 Completed - France ... More >> Marie-Victoire Senat Paris, France, 94270 Less <<
NCT03089333 Hypertension ... More >>Diabetes Mellitus, Type 2 Blood Pressure Obesity Cardiac Hypertrophy Microalbuminuria Vascular Stiffness Less << Phase 4 Completed - Brazil ... More >> University of Campinas (UNICAMP) Campinas, São Paulo, Brazil, 13083970 Less <<
NCT00835991 - Completed - -
NCT00759720 Diabetes Mellitus Phase 3 Terminated(Potential hepatic s... More >>afety signal) Less << - -
NCT00610038 Diabetes Mellitus Phase 2 Completed - France ... More >> Necker Hospital - Endocrinology Gynecology Pediatric unit Paris, France, 75015 Less <<
NCT00965991 Gestational Diabetes Not Applicable Completed - United States, New Mexico ... More >> University of New Mexico Diabetes in Pregnancy Clinic Albuquerque, New Mexico, United States, 87131 Less <<
NCT00836472 - Completed - -
NCT00835991 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Less <<
NCT00865241 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less <<
NCT00865436 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less <<
NCT03078725 Gestational Diabetes Mellitus,... More >> Class A2 Less << Phase 4 Withdrawn(Research was competi... More >>ng with other projects in the department, and no patients were recruited.) Less << May 10, 2018 -
NCT00451620 Type 2 Diabetes Phase 2 Completed - Canada, British Columbia ... More >> University of British Columbia Vancouver, British Columbia, Canada Less <<
NCT00255541 Type 2 Diabetes Phase 3 Terminated(The development pro... More >>gram has been terminated) Less << - -
NCT00864734 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less <<
NCT00734669 Type 2 Diabetes COMPLETED 2025-10-16 -
NCT02460874 Cerebral Edema ... More >> Brain Metastases Less << Phase 1 Phase 2 Recruiting October 2020 United States, Alabama ... More >> University of Alabama at Birmingham (UAB) Department of Radiation Oncology Recruiting Birmingham, Alabama, United States, 35249 Contact: Kristin Webb       kkwebb@uabmc.edu    Contact: Valerie Powell       vpowell@uabmc.edu    Principal Investigator: Drexell H Boggs, MD Less <<
NCT00279045 Diabetes Mellitus, Type 2 Phase 3 Completed - -
NCT01268683 Ischemic Stroke Phase 1 Phase 2 Completed - United States, Illinois ... More >> Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Maryland University of Maryland Medical Center Baltimore, Maryland, United States United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT01268683 - Completed - -
NCT02080377 Pregnancy Ges... More >>tational Diabetes Less << Phase 3 Completed - United Kingdom ... More >> Princess Royal Infirmary Glasgow, Lanarkshire, United Kingdom, G31 2ER Simpson Centre for Reproductive Health, Royal Infirmary Hospital, Edinburgh Edinburgh, Lothian, United Kingdom, EH16 4SA Western General Hospital Edinburgh, Lothian, United Kingdom, EH4 2XU St Johns Hospital Livingston, West Lothian, United Kingdom Queen Elizabeth Hospital Glasgow, United Kingdom Less <<
NCT01794182 Ischemic Stroke ... More >> Malignant Edema Less << Phase 2 Unknown April 2016 United States, Arizona ... More >> University of Arizona Medical Center Tucson, Arizona, United States, 85719 United States, California Stanford University Medical Center Stanford, California, United States, 94305 United States, Connecticut Yale University School of Medicine New Haven, Connecticut, United States, 06510 United States, Florida University of Florida, Jacksonville Jacksonville, Florida, United States, 32209 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 United States, Kentucky University of Louisville Hospital Louisville, Kentucky, United States, 40202 United States, Maine Maine Medical Center Scarborough, Maine, United States, 04074 United States, Maryland University of Maryland School of Medicine Baltimore, Maryland, United States, 21201 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 UMASS Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 Ohio State University Wexner Medical Center Columbus, Ohio, United States, 43210 United States, Oregon Oregon Health & Science University Hospital Portland, Oregon, United States, 97239 United States, Pennsylvania Abington Memorial Hospital Abington, Pennsylvania, United States, 19001 UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Utah University of Utah Healthcare Salt Lake City, Utah, United States, 84132 Less <<
NCT01454154 Traumatic Brain Injury Phase 2 Unknown September 2015 United States, California ... More >> University of California, San Diego San Diego, California, United States, 92103 United States, Maryland University of Maryland Medical Center, Shock Trauma Center Baltimore, Maryland, United States, 21201 United States, Pennsylvania UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, Virginia VCU Medical Center Richmond, Virginia, United States, 23298 Less <<
NCT00515801 Diabetes Mellitus, Type 1 Phase 2 Phase 3 Completed - Switzerland ... More >> University Hospital Basel Basel, Switzerland, 4031 Less <<
NCT02815787 Type 2 Diabetes Phase 1 Completed - China, Shandong ... More >> Qilu Hospital of Shandong University Jinan, Shandong, China, 250012 Less <<
NCT01716338 Healthy Volunteers Phase 1 Completed - United States, Missouri ... More >> Washington University in St. Louis Clinical Research Unit (CRU) St. Louis, Missouri, United States, 63110 Less <<
NCT02183428 Healthy Phase 1 Completed - -
NCT01822548 Type 2 Diabetes Phase 3 Completed - Italy ... More >> Azienda Opedaliera-Universitaria Parma, Italy, 43126 Azienda Ospedaliera-Universitaria Parma, Italy, 43126 Less <<
NCT02919345 Diabetes Mellitus, Type 2 ... More >> Coronary Artery Disease Carotid Artery Diseases Less << Phase 4 Unknown October 2017 Brazil ... More >> State University of Campinas Campinas, Sao Paulo, Brazil, 13083-887 Less <<
NCT02318693 Type 2 Diabetes Mellitus Phase 4 Completed - -
NCT01822548 - Completed - -
NCT01045590 Diabetes Mellitus, Type 2 Phase 4 Completed - Korea, Republic of ... More >> GSK Investigational Site Seoul, Korea, Republic of, 110-744 GSK Investigational Site Seoul, Korea, Republic of, 120-752 GSK Investigational Site Seoul, Korea, Republic of, 135-710 GSK Investigational Site Seoul, Korea, Republic of, 137-701 Less <<
NCT00417729 Diabetes Mellitus Phase 4 Completed - Taiwan ... More >> Taichung Veterans General Hospital Taichung, Taiwan Less <<
NCT01733108 Healthy Phase 1 Completed - -
NCT01867502 Diabetes Mellitus, Type 2 ... More >> Hypoglycemic Agents Diabetic Blood Glucose Monitoring Exercise Less << Phase 4 Unknown August 2015 Brazil ... More >> Hospital de Clínicas de Porto Alegre Porto Alegre Recruiting Porto Alegre, Rio Grande do Sul, Brazil, 90035-903 Contact: Aline Fofonka, MSc    55-5192339191    alinefofonka@hotmail.com    Principal Investigator: Beatriz D Schaan, PhD Less <<
NCT02726490 Gestational Diabetes Not Applicable Terminated(Lack of Recruitment... More >>) Less << - United States, Texas ... More >> TTUHSC El Paso El Paso, Texas, United States, 79905 Less <<
NCT03569540 Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << Phase 4 Recruiting December 1, 2019 Brazil ... More >> Hospital das Clínicas da Faculdade de Medicina de São Paulo Recruiting São Paulo, SP, Brazil, 05403000 Contact: Eberval Figueiredo, MD PHD    +551126617152    ebgadelha@yahoo.com    Principal Investigator: Bruno B Costa, MD          Sub-Investigator: Isabella Windlin, MD          Sub-Investigator: Nicollas R Nunes, MD          Sub-Investigator: Vitor N Yamaki, MD          Sub-Investigator: Edwin Koterba, MD, PHD Less <<
NCT02318693 - Completed - -
NCT02524379 Acute Spinal Cord Injury PHASE1|PHASE2 TERMINATED 2021-02-08 The Ohio State University, Col... More >>umbus, Ohio, 43210, United States Less <<
NCT03741530 Intracerebral Hemorrhage Not Applicable Enrolling by invitation October 31, 2020 China, Shaanxi ... More >> Xijing Hospital Xi'an, Shaanxi, China, 710032 Less <<
NCT03284463 Acute Stroke Phase 4 Recruiting September 30, 2021 China, Guangdong ... More >> Huadu District People's Hospital of Guangzhou Not yet recruiting Guangzhou, Guangdong, China, 510515 Contact: Xiangmin Liu, M.D.          Nanfang Hospital of Southern Medical University Recruiting Guangzhou, Guangdong, China Contact: Kaibin Huang       hkb@smu.edu.cn    Principal Investigator: Suyue Pan, M.D., Ph.D.          Heyuan People's Hospital Recruiting Heyuan, Guangdong, China Contact: Yunqiang Huang, M.D.    +8613750225240    13750225240@126.com    Maoming People's Hospital Recruiting Maoming, Guangdong, China Contact: Hao Li, M.D.       185416656@qq.com    Principal Investigator: Zhi Yan, M.D.          Maoming Traditional Chinese Medical Hospital Recruiting Maoming, Guangdong, China Contact: Dongrun Yan, M.D.       1792191@qq.com    Principal Investigator: Wenguo Huang, M.D.          China, Hainan Hainan Provincial Hospital of Traditional Chinese Medicine Recruiting Haikou, Hainan, China, 570100 Contact: Guangfeng Zhao, M.D.    +8613700410380    408195770@qq.com    Principal Investigator: Guohu Weng, M.D.          China, Jiangsu The First Affiliated Hospital of Wenzhou Medical University Recruiting Wenzhou, Jiangsu, China, 325000 Contact: Saijun Zhou, M.D.    +8613857746659    2498093074@qq.com    Principal Investigator: Xu Zhang, M.D. Less <<
NCT02830048 Diabetes Mellitus, Type 2 PHASE2 COMPLETED 2017-03-09 Clinical Research Unit, OCDEM,... More >> Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, United Kingdom Less <<
NCT01456650 Type 2 Diabetes PHASE4 COMPLETED 2025-12-12 Instituto Nacional de Ciencias... More >> Medicas y Nutricion, Mexico City, DF, 14000, Mexico Less <<
NCT02145611 Type 2 Diabetes Mellitus ... More >> Hypertension Endothelial Dysfunction Less << Phase 4 Completed - Brazil ... More >> Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, São Paulo, Brazil, 15090-000 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.12mL

2.02mL

1.01mL

20.24mL

4.05mL

2.02mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories