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Chemistry
Organic Building Blocks
Benzene Compounds
fluorene
Fmoc-Vinyl-Gly-OH
Chemistry
Organic Building Blocks
Benzene Compounds
Carbamates
fluorene
9-fluorenylmethoxycarbonyl fluorenyl

[ CAS No. 1025434-04-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1025434-04-1
Chemical Structure| 1025434-04-1
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Quality Control of [ 1025434-04-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
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Product Details of [ 1025434-04-1 ]

CAS No. :1025434-04-1 MDL No. :MFCD02682488
Formula : C19H17NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :WKYFUFWCJIKRCS-KRWDZBQOSA-N
M.W : 323.34 Pubchem ID :66601066
Synonyms :
Chemical Name :(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)but-3-enoic acid

Calculated chemistry of [ 1025434-04-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 24
Num. arom. heavy atoms : 12
Fraction Csp3 : 0.16
Num. rotatable bonds : 7
Num. H-bond acceptors : 4.0
Num. H-bond donors : 2.0
Molar Refractivity : 89.5
TPSA : 75.63 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.79 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.73
Log Po/w (XLOGP3) : 3.5
Log Po/w (WLOGP) : 3.16
Log Po/w (MLOGP) : 2.48
Log Po/w (SILICOS-IT) : 2.91
Consensus Log Po/w : 2.96

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -3.96
Solubility : 0.0356 mg/ml ; 0.00011 mol/l
Class : Soluble
Log S (Ali) : -4.77
Solubility : 0.00547 mg/ml ; 0.0000169 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -4.95
Solubility : 0.00365 mg/ml ; 0.0000113 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 3.57

Safety of [ 1025434-04-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 UN#:N/A
Hazard Statements:H302-H312-H332 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1025434-04-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1025434-04-1 ]

[ 1025434-04-1 ] Synthesis Path-Downstream   1~27

  • 1
  • [ 1025434-04-1 ]
  • [ 500872-36-6 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride In dichloromethane at 20 - 40℃; for 2h;
With thionyl chloride In dichloromethane at 0℃; for 3h; Reflux; Inert atmosphere;
With thionyl chloride In dichloromethane at 0℃; for 3h; Reflux;
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
[2]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
[3]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]
  • 2
  • [ 500872-35-5 ]
  • [ 1025434-04-1 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride In 1,4-dioxane at 80℃; for 48h;
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 3
  • [ 1025434-04-1 ]
  • [3-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-2-oxo-3,6-dihydro-2<i>H</i>-benzo[<i>b</i>]azocin-1-yl]-acetic acid <i>tert</i>-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 78 percent / CH2Cl2 / 16 h / 20 °C 3: 99 percent / Ru-containing catalyst / CH2Cl2 / 16 h / Heating
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 4
  • [ 1025434-04-1 ]
  • [ 500872-38-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 78 percent / CH2Cl2 / 16 h / 20 °C
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 5
  • [ 1025434-04-1 ]
  • [8-bromo-3-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-2-oxo-3,6-dihydro-2<i>H</i>-benzo[<i>b</i>]azocin-1-yl]-acetic acid <i>tert</i>-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 65 percent / CH2Cl2 / 16 h / 20 °C 3: 94 percent / Ru-containing catalyst / CH2Cl2 / 16 h / Heating
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 6
  • [ 1025434-04-1 ]
  • [3-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-8-methoxy-2-oxo-3,6-dihydro-2<i>H</i>-benzo[<i>b</i>]azocin-1-yl]-acetic acid <i>tert</i>-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 77 percent / CH2Cl2 / 16 h / 20 °C 3: 99 percent / Ru-containing catalyst / CH2Cl2 / 16 h / Heating
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 7
  • [ 1025434-04-1 ]
  • [ 500872-47-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 65 percent / CH2Cl2 / 16 h / 20 °C
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 8
  • [ 1025434-04-1 ]
  • [ 500872-48-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: SOCl2 / CH2Cl2 / 2 h / 20 - 40 °C 2: 77 percent / CH2Cl2 / 16 h / 20 °C
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 9
  • [ 500872-34-4 ]
  • [ 1025434-04-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: NaIO4 / methanol; H2O / 20 h / 0 - 20 °C 2: xylene / 72 h / 150 °C 3: aq. HCl / dioxane / 48 h / 80 °C
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 10
  • methyl (2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-(methylsulfonyl)butanoate [ No CAS ]
  • [ 1025434-04-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: xylene / 72 h / 150 °C 2: aq. HCl / dioxane / 48 h / 80 °C
Reference： [1]Organ, Michael G; Xu, Juan; N'Zemba, Blaise [Tetrahedron Letters, 2002, vol. 43, # 45, p. 8177 - 8180]
  • 11
  • [ 35661-60-0 ]
  • [ 35661-39-3 ]
  • [ 71989-23-6 ]
  • [ 71989-26-9 ]
  • [ 71989-35-0 ]
  • [ 71989-28-1 ]
  • [ 132388-59-1 ]
  • [ 132327-80-1 ]
  • [ 143824-78-6 ]
  • Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ]
  • [ 1025434-04-1 ]
  • H-(vinylglycyl)-QGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA-NH2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Automated synthesizer; solid phase reaction; Stage #2: solid phase reaction; Stage #3: Fmoc-Leu-OH; Fmoc-Ile-OH; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-Thr(tBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; (S)-N-(Fmoc)vinylglycine Further stages;
Reference： [1]Location in patent: experimental part Santoprete, Alessia; Capito, Elena; Carrington, Paul E.; Pocai, Alessandro; Finotto, Marco; Langella, Annunziata; Ingallinella, Paolo; Zytko, Karolina; Bufali, Simone; Cianetti, Simona; Veneziano, Maria; Bonelli, Fabio; Zhu, Lan; Monteagudo, Edith; Marsh, Donald J.; Sinharoy, Ranabir; Bianchi, Elisabetta; Pessi, Antonello [Journal of Peptide Science, 2011, vol. 17, # 4, p. 270 - 280]
  • 12
  • [ 1025434-04-1 ]
  • di-(tert-butyl) (2S,3E,6R)-6-[(tert-butoxycarbonyl)amino]-2-[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-heptenedioate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: boron trifluoride diethyl etherate / dichloromethane; cyclohexane / Inert atmosphere 2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / Inert atmosphere; Reflux
Reference： [1]Jakopin, Žiga; Gobec, Martina; Kodela, Jaka; Hazdovac, Toni; Mlinarič-Raščan, Irena; Sollner Dolenc, Marija [European Journal of Medicinal Chemistry, 2013, vol. 69, p. 232 - 243]
  • 13
  • [ 98946-18-0 ]
  • [ 1025434-04-1 ]
  • tert-butyl (2S)-2-[(9H-(fluoren-9-ylmethoxy)carbonyl)]amino}-3-butenoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
933 mg With boron trifluoride diethyl etherate In dichloromethane; cyclohexane Inert atmosphere; 4.2.1 Cross-metathesis between allylglycine and vinylglycine derivatives General procedure: A solution of allylglycine derivative (0.50mmol) and vinylglycine derivative (0.90mmol) in dichloromethane (6mL) wasbubbled with Ar for 5min, and then cannulated into a flask containing the Grubbs' second generation catalyst (10mol%). Thereaction mixture was refluxed overnight. The mixture was concentrated in vacuo and the residue was purified by flash silica gel column chromatography (eluent: hexane/ethyl acetate 8:1 v/v) to afford the cross-coupled products 9 or 10, respectively.
Reference： [1]Jakopin, Žiga; Gobec, Martina; Kodela, Jaka; Hazdovac, Toni; Mlinarič-Raščan, Irena; Sollner Dolenc, Marija [European Journal of Medicinal Chemistry, 2013, vol. 69, p. 232 - 243]
  • 14
  • [ 24424-99-5 ]
  • [ 75266-38-5 ]
  • [ 1025434-04-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; In 1,4-dioxane; water;Inert atmosphere; Reflux; General procedure: A solution of allylglycine derivative (0.50mmol) and vinylglycine derivative (0.90mmol) in dichloromethane (6mL) wasbubbled with Ar for 5min, and then cannulated into a flask containing the Grubbs' second generation catalyst (10molpercent). Thereaction mixture was refluxed overnight. The mixture was concentrated in vacuo and the residue was purified by flash silica gel column chromatography (eluent: hexane/ethyl acetate 8:1 v/v) to afford the cross-coupled products 9 or 10, respectively.
Reference： [1]European Journal of Medicinal Chemistry,2013,vol. 69,p. 232 - 243
  • 15
  • [ 1025434-04-1 ]
  • (S,S)-methyl 2-[N-[2-(N-Fmoc-amino)but-3-enoyl]-N-(2,4-dimethoxybenzyl)amino]hex-5-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 16
  • [ 1025434-04-1 ]
  • (S,S)-methyl 2-[N-[2-(N-Fmoc-amino)but-3-enoyl]-N-(2,4-dimethoxybenzyl)amino]hept-6-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 17
  • [ 1025434-04-1 ]
  • (3S,10S,Z) methyl 3-(N-Fmoc-amino)-1-(2,4-dimethoxybenzyl)-2-oxo-1,2,3,6,7,8-hexahydroazocine-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: Grubbs catalyst first generation / dichloromethane / 72 h / Inert atmosphere; Reflux
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 18
  • [ 1025434-04-1 ]
  • (3S,9S,Z)-methyl 3-(N-Fmoc-amino)-1-(2,4-dimethoxybenzyl)-2-oxo-1,2,3,6,7,8,9-heptahydro-1H-azonine-9-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: Grubbs catalyst first generation / dichloromethane / 48 h / Inert atmosphere; Reflux
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 19
  • [ 1025434-04-1 ]
  • (3S,8S,Z)-methyl 3-(N-Fmoc-amino)-2-oxo-1,2,3,6,7,8-hexahydroazocine-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: Grubbs catalyst first generation / dichloromethane / 72 h / Inert atmosphere; Reflux 4: trifluoroacetic acid / dichloromethane / Inert atmosphere
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 20
  • [ 1025434-04-1 ]
  • (3S,9S,Z)-methyl 3-(N-Fmoc-amino)-2-oxo-1,2,3,6,7,8,9-heptahydro-1H-azonine-9-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: Grubbs catalyst first generation / dichloromethane / 48 h / Inert atmosphere; Reflux 4: trifluoroacetic acid / dichloromethane / Inert atmosphere
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 21
  • [ 1025434-04-1 ]
  • (3R,4S,5S,8S)-methyl 3-(N-Fmoc-amino)-4-iodo-2-oxohexahydro-5H-pyrrolizine-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux; Inert atmosphere 2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 3: Grubbs catalyst first generation / dichloromethane / 72 h / Inert atmosphere; Reflux 4: trifluoroacetic acid / dichloromethane / Inert atmosphere 5: iodine; [bis(acetoxy)iodo]benzene / acetonitrile / 0.5 h / 80 °C / Inert atmosphere; Darkness
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 22
  • [ 851909-11-0 ]
  • [ 1025434-04-1 ]
  • (Z,S)-methyl 2-[N-[2-(N-Fmoc-amino)but-3-enoyl]-N-(2,4-dimethoxybenzyl)amino]hex-5-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 24h; Inert atmosphere;
Reference： [1]Atmuri, N. D. Prasad; Lubell, William D. [Journal of Organic Chemistry, 2015, vol. 80, # 10, p. 4904 - 4918]
  • 23
  • [ 1025434-04-1 ]
  • (S,S)-methyl 2-[N-[2-(N-Fmoc-amino)but-3-enoyl]-N-(2,4-dimethoxybenzyl)amino]pent-4-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux 2: dichloromethane / 3 h / 0 - 20 °C
Reference： [1]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]
  • 24
  • [ 1025434-04-1 ]
  • (3S,4R,5R,7S)-methyl 3-(N-Fmoc-amino)-5-iodo-6-acetoxy-2-oxoazocane-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux 2: dichloromethane / 3 h / 0 - 20 °C 3: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux 4: trifluoroacetic acid / dichloromethane 5: iodine / toluene / 0.5 h / 80 °C
Reference： [1]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]
  • 25
  • [ 1025434-04-1 ]
  • (3S)-methyl 3-(N-Fmoc-amino)-2-oxo-2,3-dihydro-1H-azepine-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux 2: dichloromethane / 3 h / 0 - 20 °C 3: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux 4: trifluoroacetic acid / dichloromethane 5: 1-<bis(adamantylcarbonyloxy)iodo>-4-methoxybenzene; iodine / toluene / 0.5 h / 80 °C / Darkness
Reference： [1]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]
  • 26
  • [ 1025434-04-1 ]
  • (3S,7S)-methyl 3-(N-Fmoc-amino)-1-(2,4-dimethoxybenzyl)-2-oxo-2,3,6,7-tetrahydro-1Hazepine-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux 2: dichloromethane / 3 h / 0 - 20 °C 3: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux
Reference： [1]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]
  • 27
  • [ 1025434-04-1 ]
  • (3S,7S)-methyl 3-(N-Fmoc-amino)-2-oxo-2,3,6,7-tetrahydro-1H-azepine-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane / 3 h / 0 °C / Reflux 2: dichloromethane / 3 h / 0 - 20 °C 3: Grubbs catalyst first generation / dichloromethane / 48 h / Reflux 4: trifluoroacetic acid / dichloromethane
Reference： [1]Atmuri, N.D. Prasad; Reilley, David J.; Lubell, William D. [Organic Letters, 2017, vol. 19, # 19, p. 5066 - 5069]

Tags: 1025434-04-1 synthesis path| 1025434-04-1 SDS| 1025434-04-1 COA| 1025434-04-1 purity| 1025434-04-1 application| 1025434-04-1 NMR| 1025434-04-1 COA| 1025434-04-1 structure

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Technical Information

• Benzylic Oxidation • Birch Reduction • Birch Reduction of Benzene • Blanc Chloromethylation • Complete Benzylic Oxidations of Alkyl Chains • Complete Benzylic Oxidations of Alkyl Chains • Conversion of Amino with Nitro • Deprotonation of Methylbenzene • Directing Electron-Donating Effects of Alkyl • Electrophilic Chloromethylation of Polystyrene • Friedel-Crafts Alkylation of Benzene with Acyl Chlorides • Friedel-Crafts Alkylation of Benzene with Carboxylic Anhydrides • Friedel-Crafts Alkylation Using Alkenes • Friedel-Crafts Alkylations of Benzene Using Alkenes • Friedel-Crafts Alkylations Using Alcohols • Friedel-Crafts Reaction • Groups that Withdraw Electrons Inductively Are Deactivating and Meta Directing • Halogenation of Benzene • Hydrogenation to Cyclohexane • Hydrogenolysis of Benzyl Ether • Nitration of Benzene • Nucleophilic Aromatic Substitution • Nucleophilic Aromatic Substitution with Amine • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Preparation of Alkylbenzene • Reactions of Benzene and Substituted Benzenes • Reductive Removal of a Diazonium Group • Reverse Sulfonation——Hydrolysis • Sulfonation of Benzene • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Nitro Group Conver to the Amino Function • Vilsmeier-Haack Reaction
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